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Literature summary for 2.7.1.60 extracted from

  • Hinderlich, S.; Sonnenschein, A.; Reutter, W.
    Metal ion requirement of bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase from rat liver (1998), BioMetals, 11, 253-258.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
NaCl ManNAc kinase activity is increased by presence of 200 mM Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
Cd2+ less effective Rattus norvegicus
Mg2+
-
Rattus norvegicus
additional information Ca2+, Ba2+, Cu2+, Fe2+, Sn2+ and Zn2+ shows no effect on enzyme activity, monovalent cations Li+, Na+, K+, Rb+ or Cs+ cannot replace Mg2+ Rattus norvegicus
Ni2+ less effective Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + N-acetyl-D-mannosamine Rattus norvegicus involved in N-acetylneuraminic acid metabolism, key enzyme in N-acetylneuraminic acid biosynthesis ADP + N-acetyl-D-mannosamine 6-phosphate
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + N-acetyl-D-mannosamine involved in N-acetylneuraminic acid metabolism, key enzyme in N-acetylneuraminic acid biosynthesis Rattus norvegicus ADP + N-acetyl-D-mannosamine 6-phosphate
-
?
ATP + N-acetyl-D-mannosamine
-
Rattus norvegicus ADP + N-acetyl-D-mannosamine-6-phosphate
-
?
additional information UDP-GlcNAc 2-epimerase and ManNAc kinase are parts of one bifunctional enzyme, catalyzes the first 2 steps in N-acetylneuraminic acid biosynthesis Rattus norvegicus ?
-
?

Synonyms

Synonyms Comment Organism
EC 5.1.3.14/EC 2.7.1.60
-
Rattus norvegicus
ManAc kinase
-
Rattus norvegicus
UDP-GlcNAc-epimerase/ManNAc kinase
-
Rattus norvegicus