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Literature summary for 2.7.1.60 extracted from

  • Reinke, S.O.; Hinderlich, S.
    Prediction of three different isoforms of the human UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (2007), FEBS Lett., 581, 3327-3331.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9Y223
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Homo sapiens Q9Y223 isoform 2; bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase, isoform GNE2
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Homo sapiens Q9Y223 isoform 3; bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase, isoform GNE3
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Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Homo sapiens
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colon
-
Homo sapiens
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kidney
-
Homo sapiens
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liver
-
Homo sapiens
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lung
-
Homo sapiens
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pancreas
-
Homo sapiens
-
placenta
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + N-acetyl-D-mannosamine
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Homo sapiens ADP + N-acetyl-D-mannosamine 6-phosphate
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?
additional information isoform GNE2 displays an extended N-terminus compared with isoform GNE, which is linked directly to the epimerase domain. Recombinant GNE2 still possesses both enzymatic activities of GNE Homo sapiens ?
-
?
additional information isoform GNE3 displays an deleted N-terminus compared with isoform GNE. Recombinant GNE3 shows a total loss of the epimerase activity Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
GNE2 enzyme isoform possessing extended N-terminus Homo sapiens
GNE3 enzyme isoform possessing deleted N-terminus Homo sapiens
UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase
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Homo sapiens