Literature summary for 2.7.1.60 extracted from

Gagiannis, D.; Orthmann, A.; Danssmann, I.; Schwarzkopf, M.; Weidemann, W.; Horstkorte, R.
Reduced sialylation status in UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine kinase (GNE)-deficient mice (2007), Glycoconj. J., 24, 125-130.

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Protein Variants

Protein Variants	Comment	Organism
additional information	heterozygous mice deficient for bifunctional UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine kinase display a organ-specific reduction of membrane-bound sialic acids of about 25%. Transferrin expression is unchanged in heterozygous mice, but the isoelectric point of transferrin is shifted towards basic pH value. The expression of polysialic acids on polysialylated neural cell adhesion molecule is reduced	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	bifunctional UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine kinase	-

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Release 2023.1 (January 2023)