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Literature summary for 2.7.1.60 extracted from

  • Lucka, L.; Krause, M.; Danker, K.; Reutter, W.; Horstkorte, R.
    Primary structure and expression analysis of human UDP-N-acetyl-glucosamine-2-epimerase/N-acetylmannosamine kinase, the bifunctional enzyme in neuraminic acid biosynthesis (1999), FEBS Lett., 454, 341-344.
    View publication on PubMed
Search for more literature for 2.7.1.60

Application

Application Comment Organism
medicine clinical relevance of the enzyme in the basic defect in sialuria Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
cDNA cloned and sequenced, expressed in Escherichia coli HB101 or INValphaF' Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
79000
-
 assembles to dimer or hexamer Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9Y223 human cell lines promyeolytic leukaemia HL-60, HeLa S3, chronic myelogenous leukaemia K-562, lymphoblastic leukaemia MOLT-4, Burkitt's lymphoma Raji, colorectal adenocarcinoma SW480, lung carcinoma A549 and melanoma G361
-

Source Tissue

Source Tissue Comment Organism Textmining
HeLa-S3 cell
-
 Homo sapiens
-
HL-60 cell
-
 Homo sapiens
-
K-562 cell
-
 Homo sapiens
-
liver
-
 Homo sapiens
-
placenta
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information UDP-GlcNAc 2-epimerase and ManNAc kinase are parts of one bifunctional enzyme, catalyzes the first 2 steps in N-acetylneuraminic acid biosynthesis Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
dimer
-
 Homo sapiens
hexamer
-
 Homo sapiens

Synonyms

Synonyms Comment Organism
EC 5.1.3.14/EC 2.7.1.60
-
 Homo sapiens
UDP-GlcNAc-epimerase/ManNAc kinase
-
 Homo sapiens