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Literature summary for 2.7.1.60 extracted from

  • Kundig, W.; Ghosh, S.; Roseman, S.
    The sialic acids. VII. N-acyl-D-mannosamine kinase from rat liver (1966), J. Biol. Chem., 241, 5619-5626.
    View publication on PubMed

General Stability

General Stability Organism
purified enzyme is unstable to ammonium sulfate precipitation or freezing and thawing Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.2
-
N-acetyl-D-mannosamine pH 8.1, 37°C Rattus norvegicus
1.2
-
N-glycolylmannosamine pH 8.1, 37°C Rattus norvegicus
2
-
ATP pH 8.1, 37°C Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required for activity Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + N-acetyl-D-mannosamine Rattus norvegicus metabolic pathway between hexoses and sialic acids ADP + N-acetyl-D-mannosamine 6-phosphate
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
rat, albino
-

Purification (Commentary)

Purification (Comment) Organism
-
Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
Rattus norvegicus
-
liver
-
Rattus norvegicus
-
additional information no enzymatic activity in brain, heart and muscle Rattus norvegicus
-
spleen
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.5
-
activity of fraction with N-glycolylmannosamine Rattus norvegicus
2.76
-
activity of fraction with N-glycolylmannosamine Rattus norvegicus
4
-
activity of fraction with N-acetylmannosamine Rattus norvegicus

Storage Stability

Storage Stability Organism
0°C, loses about 50% of its activity in 24 hours, stable for at least 1 week in presence of 0.01 M N-acylmannosamine Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + N-acetyl-D-mannosamine metabolic pathway between hexoses and sialic acids Rattus norvegicus ADP + N-acetyl-D-mannosamine 6-phosphate
-
?
ATP + N-acetyl-D-mannosamine
-
Rattus norvegicus ADP + N-acetyl-D-mannosamine-6-phosphate
-
?
ATP + N-glycolylmannosamine
-
Rattus norvegicus N-glycolylmannosamine-6-phosphate
-
?
additional information N-acetylglucosamine and N-glycolylglucosamine, N-acetylgalactosamine, mannosamine, glucosamine, galactosamine, mannose, galactose, fructose, glucose, glucose-1-phosphate and glucose-6-phosphate are inactive as substrates, the phosphoryl donor ATP cannot be replaced by GTP, UTP, CTP, TTP, dATP or phosphoenolpyruvate Rattus norvegicus ?
-
?