3.1.22.1: deoxyribonuclease II
This is an abbreviated version!
For detailed information about deoxyribonuclease II, go to the full flat file.
Word Map on EC 3.1.22.1
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3.1.22.1
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chromatin
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endonuclease
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nuclei
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spleen
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nucleases
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nucleosome
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cathepsins
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micrococcal
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engulf
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caspase-independent
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spiralis
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medicine
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trichinella
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caspase-activated
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dnaase
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ii-like
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internucleosomal
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undigested
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endonucleolytic
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nonhistone
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corpses
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cation-independent
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analysis
- 3.1.22.1
- chromatin
- endonuclease
- nuclei
- spleen
- nucleases
- nucleosome
- cathepsins
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micrococcal
-
engulf
-
caspase-independent
- spiralis
- medicine
- trichinella
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caspase-activated
- dnaase
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ii-like
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internucleosomal
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undigested
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endonucleolytic
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nonhistone
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corpses
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cation-independent
- analysis
Reaction
endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotide end-products =
Synonyms
acid deoxyribonuclease, acid DNase, crn-7, deoxyribonuclease II, deoxyribonuclease IIalpha, deoxyribonuclease IIbeta, deoxyribonucleate 3'-nucleotidohydrolase, DNase 2, DNase 2a, DNase II, DNase II homolog, DNase II-1, DNase II-7, DNase IIalpha, DNase IIb, DNase IIbeta, EC 3.1.4.6, L-DNase II, LEI, LEI-derived DNase II, LEI/L-DNase II, leukocyte elastase inhibitor-derived DNase II, leukocyte elastase inhibitor/LEI-derived DNase II, lysosomal DNase II, Nuc-1, NUC-1 apoptotic nuclease, pancreatic DNase II, plancitoxin 1, R31240_2, Sjda, TsDNase II-1, TsDNase II-7
ECTree
3.1.22.1 deoxyribonuclease IIAdvanced search results
results (
results (Inhibitors
Inhibitors on EC 3.1.22.1 - deoxyribonuclease II
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INHIBITOR 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
EDTA
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dialysis of IgGs from rabbits immunized with DNase II against a buffer containing EDTA or addition of EDTA to the reaction mixture leads to a complete disappearance of DNase activity
growth hormone
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in mice fed a 20% protein diet, growth hormone treatment decreases elevated activites of DNase II and RNase
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human growth hormone
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treatment of post-weaning mice results in 63% inhibition in gastrocnemius muscle
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RNAi
Drosophila sp. (in: flies)
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expression of a DNase IIRNAi construct in flies results in a significant decrease in total hemocyte numbers
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bovine serum albumin
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90% inhibition at 0.015 mg/ml, addition of inhibitor changes pH-activity curve, optimal pH shifted to the alkaline side, DNA substrate compete with inhibitor and reverses inhibitor action
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bovine serum albumin
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90% inhibition at 0.015 mg/ml, addition of inhibitor changes pH-activity curve, optimal pH shifted to the alkaline side, DNA substrate compete with inhibitor and reverses inhibitor action
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Cu2+
inhibited by copper ions and to a lesser extent manganese ions, but not inhibited by calcium, magnesium or zinc ions
Mg2+
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addition of Mg2+ ions to the dialyzed preparations of IgGs leads to a reduction of the IgG DNase activity
Mg2+
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slightly inhibitory at 10 mM and pH 4.5, inhibitory effects depending on enzyme purity
Mn2+
inhibited by copper ions and to a lesser extent manganese ions, but not inhibited by calcium, magnesium or zinc ions
tunicamycin
inhibits the N-linked glycosylation and virtually abolishes the enzyme activity
additional information
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caspases inhibitors have no effect on acid endonucleases, and no effect on apoptosis
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additional information
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despite having putative poly(ADP-ribose)-acceptor sites, LEI/L-DNase II is neither significantly poly(ADP-ribosyl)ated nor inhibited by PARP-1 during caspase-independent apoptosis
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