3.1.22.1: deoxyribonuclease II

This is an abbreviated version!
For detailed information about deoxyribonuclease II, go to the full flat file.

Word Map on EC 3.1.22.1

3.1.22.1

chromatin

endonuclease

nuclei

spleen

nucleases

nucleosome

cathepsins

micrococcal

engulf

caspase-independent

spiralis

medicine

trichinella

caspase-activated

dnaase

ii-like

internucleosomal

undigested

endonucleolytic

nonhistone

corpses

cation-independent

analysis

Reaction

endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotide end-products =

Synonyms

acid deoxyribonuclease, acid DNase, crn-7, deoxyribonuclease II, deoxyribonuclease IIalpha, deoxyribonuclease IIbeta, deoxyribonucleate 3'-nucleotidohydrolase, DNase 2, DNase 2a, DNase II, DNase II homolog, DNase II-1, DNase II-7, DNase IIalpha, DNase IIb, DNase IIbeta, EC 3.1.4.6, L-DNase II, LEI, LEI-derived DNase II, LEI/L-DNase II, leukocyte elastase inhibitor-derived DNase II, leukocyte elastase inhibitor/LEI-derived DNase II, lysosomal DNase II, Nuc-1, NUC-1 apoptotic nuclease, pancreatic DNase II, plancitoxin 1, R31240_2, Sjda, TsDNase II-1, TsDNase II-7

ECTree

3 Hydrolases

3.1 Acting on ester bonds

3.1.22 Endodeoxyribonucleases producing 3'-phosphomonoesters

3.1.22.1 deoxyribonuclease II

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Results	in table
20	Activating Compound
1441	AA Sequence
20	Application
1	CAS Registry Number
24	Cloned(Commentary)
2	Crystallization (Commentary)
270	Disease/ Diagnostics
1	Expression
16	General Information
3	General Stability
64	Inhibitors
6	KM Value [mM]
39	Localization
10	Metals/Ions
37	Molecular Weight [Da]
37	Natural Substrates/ Products (Substrates)
1	Organic Solvent Stability
144	Organism
1	Oxidation Stability
20	pH Optimum
6	pH Range
2	pH Stability
2	pI Value
13	Posttranslational Modification
53	Protein Variants
28	Purification (Commentary)
6	Reaction
1	Reaction Type
129	Reference
125	Source Tissue
21	Specific Activity [micromol/min/mg]
2	Storage Stability
106	Substrates and Products (Substrate)
10	Subunits
108	Synonyms
4	Temperature Optimum [°C]
1	Temperature Range [°C]
5	Temperature Stability [°C]
6	Turnover Number [1/s]

Specific Activity

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Specific Activity on EC 3.1.22.1 - deoxyribonuclease II

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0.002

0.42 - 0.51

138

mutant H207L, pH 4.7

172

mutant H274L, pH 4.7

219

mutant H206L, pH 4.7

220

mutant H41L, pH 4.7

287

mutant H109L, pH 4.7

302000

pH 5.0

321

wild-type, pH 4.7

327.1

74.3fold purified

331

mutant H322L, pH 4.7

4.4

1fold purified

additional information

9 entries