3.1.22.1: deoxyribonuclease II

This is an abbreviated version!
For detailed information about deoxyribonuclease II, go to the full flat file.

Reaction

endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotide end-products =

Synonyms

acid deoxyribonuclease, acid DNase, crn-7, deoxyribonuclease II, deoxyribonuclease IIalpha, deoxyribonuclease IIbeta, deoxyribonucleate 3'-nucleotidohydrolase, DNase 2, DNase 2a, DNase II, DNase II homolog, DNase II-1, DNase II-7, DNase IIalpha, DNase IIb, DNase IIbeta, EC 3.1.4.6, L-DNase II, LEI, LEI-derived DNase II, LEI/L-DNase II, leukocyte elastase inhibitor-derived DNase II, leukocyte elastase inhibitor/LEI-derived DNase II, lysosomal DNase II, Nuc-1, NUC-1 apoptotic nuclease, pancreatic DNase II, plancitoxin 1, R31240_2, Sjda, TsDNase II-1, TsDNase II-7

ECTree

     3 Hydrolases

         3.1 Acting on ester bonds

             3.1.22 Endodeoxyribonucleases producing 3'-phosphomonoesters

                3.1.22.1 deoxyribonuclease II

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Results	in table
20	Activating Compound
1441	AA Sequence
20	Application
1	CAS Registry Number
24	Cloned(Commentary)
2	Crystallization (Commentary)
270	Disease/ Diagnostics
1	Expression
16	General Information
3	General Stability
64	Inhibitors
6	KM Value [mM]
39	Localization
10	Metals/Ions
37	Molecular Weight [Da]
37	Natural Substrates/ Products (Substrates)
1	Organic Solvent Stability
144	Organism
1	Oxidation Stability
20	pH Optimum
6	pH Range
2	pH Stability
2	pI Value
13	Posttranslational Modification
53	Protein Variants
28	Purification (Commentary)
6	Reaction
1	Reaction Type
129	Reference
125	Source Tissue
21	Specific Activity [micromol/min/mg]
2	Storage Stability
106	Substrates and Products (Substrate)
10	Subunits
108	Synonyms
4	Temperature Optimum [°C]
1	Temperature Range [°C]
5	Temperature Stability [°C]
6	Turnover Number [1/s]

Crystallization

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Crystallization on EC 3.1.22.1 - deoxyribonuclease II

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CRYSTALLIZATION (Commentary)

ORGANISM

UNIPROT

LITERATURE

crystals of BthDNase II grown from a solution containing 0.0004 ml of protein at 26.5 mg/ml and 0.0004 ml of precipitant equilibrated against 0.080 ml of precipitant (100 mM BisTris pH 6.5, 28% (w/v) PEG MME 2000). A single crystal is cryo-protected with 15% (v/v) ethylene glycol and vitrified in liquid nitrogen. Crystal structure solved at 1.65 A resolution

Burkholderia thailandensis

Q2T8B0

751743

structural model of protein. DNase IIalpha is a monomeric enzyme with pseudodimeric fold. It contains two requisite PLD-signature motifs in the N-terminal subdomains which together form a single active site

Homo sapiens

-

682740