3.1.22.1: deoxyribonuclease II
This is an abbreviated version!
For detailed information about deoxyribonuclease II, go to the full flat file.
Word Map on EC 3.1.22.1
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3.1.22.1
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chromatin
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endonuclease
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nuclei
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spleen
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nucleases
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nucleosome
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cathepsins
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micrococcal
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engulf
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caspase-independent
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spiralis
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medicine
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trichinella
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caspase-activated
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dnaase
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ii-like
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internucleosomal
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undigested
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endonucleolytic
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nonhistone
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corpses
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cation-independent
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analysis
- 3.1.22.1
- chromatin
- endonuclease
- nuclei
- spleen
- nucleases
- nucleosome
- cathepsins
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micrococcal
-
engulf
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caspase-independent
- spiralis
- medicine
- trichinella
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caspase-activated
- dnaase
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ii-like
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internucleosomal
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undigested
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endonucleolytic
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nonhistone
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corpses
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cation-independent
- analysis
Reaction
endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotide end-products =
Synonyms
acid deoxyribonuclease, acid DNase, crn-7, deoxyribonuclease II, deoxyribonuclease IIalpha, deoxyribonuclease IIbeta, deoxyribonucleate 3'-nucleotidohydrolase, DNase 2, DNase 2a, DNase II, DNase II homolog, DNase II-1, DNase II-7, DNase IIalpha, DNase IIb, DNase IIbeta, EC 3.1.4.6, L-DNase II, LEI, LEI-derived DNase II, LEI/L-DNase II, leukocyte elastase inhibitor-derived DNase II, leukocyte elastase inhibitor/LEI-derived DNase II, lysosomal DNase II, Nuc-1, NUC-1 apoptotic nuclease, pancreatic DNase II, plancitoxin 1, R31240_2, Sjda, TsDNase II-1, TsDNase II-7
ECTree
3.1.22.1 deoxyribonuclease IIAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 3.1.22.1 - deoxyribonuclease II
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
DNA + H2O
3'-phosphooligonucleotide
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using TdT-mediated dUTP-nicked-end labelling, TUNEL, is followed DNA fragmentation that occurs in vivo during programmed cell death, Nuc-1 functions in the elimination of TUNEL-reactive DNA ends to a TUNEL nonreactive state
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?
DNA + H2O
?
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the enzyme could be one of the factors in the late block to polyspermy in the cytoplasm of avian eggs, the enzyme activity might also be responsible for poor efficiency in obtaining transgenic birds by microinjection of exogenous DNA into the fertilised chick ovum
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?
DNA + H2O
3'-phosphooligonucleotides + 5'-hydroxyoligonucleotides
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ethanol stress on ARPE-19 cells can induce a pathway which is a form of programmed cell death with characteristics of both apoptosis and necrosis, possibly by triggering conversion of leukocyte elastase inhibitor LEI to L-DNase II
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-
?
DNA + H2O
3'-phosphooligonucleotides + 5'-hydroxyoligonucleotides
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the enzyme in macrophages appears to be responsible for destroying the nuclear DNA expelled from erythroid precursor cells
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?
DNA + H2O
3'-phosphooligonucleotides + 5'-hydroxyoligonucleotides
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it is proposed that DNase II together with the Chk2, p53, and p21 pathway forms a genetic barrier blocking the replication of potentially harmful DNA introduced via apoptotic bodies, thereby preventing transformation and malignant development
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?
DNA + H2O
3'-phosphooligonucleotides + 5'-hydroxyoligonucleotides
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The LEI/L-DNase II pathway is activated in light-induced retinal degeneration
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-
?
DNA + H2O
3'-phosphooligonucleotides + 5'-hydroxyoligonucleotides
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The LEI/L-DNase II pathway is activated in light-induced retinal degeneration
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-
?
DNA + H2O
oligonucleotides + ?
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induces DNA digestion during apoptosis
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?
DNA + H2O
oligonucleotides + ?
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cleaves DNA in co-ordination with other nucleases to produce internucleosomal degradation
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?
DNA + H2O
oligonucleotides + ?
induces DNA digestion during apoptosis
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?
DNA + H2O
oligonucleotides + ?
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prefers to cut purine-rich steps in duplex-DNA, will also attack heat-denatured and single-stranded substrates
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?
DNA + H2O
oligonucleotides + ?
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induces DNA digestion during apoptosis
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?
DNA + H2O
oligonucleotides + ?
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involvement in recombination, replication and degradation of DNA
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?
DNA + H2O
oligonucleotides + ?
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transformation from leukocyte elastase inhibitor to L-DNase II acts as a switch of protease and nuclease pathways
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?
nuclei + H2O
oligonucleotides + ?
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convertes genomic DNA into fragments of less than 2 kbp
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?
nuclei + H2O
oligonucleotides + ?
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the 6.5 kbp EcoRI fragment containing the beta-globin gene region shows a 6fold increased sensitivity to DNase II
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?
additional information
?
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The enzyme is required for digesting DNA of apoptotic cell corpses and dietary DNA, it is not required for viability.
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?
additional information
?
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The enzyme is required for digesting DNA of apoptotic cell corpses and dietary DNA, it is not required for viability.
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?
additional information
?
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The enzyme is required for digesting DNA of apoptotic cell corpses and dietary DNA, it is not required for viability.
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?
additional information
?
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The enzyme is required for digesting DNA of apoptotic cell corpses and dietary DNA, it is not required for viability.
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?
additional information
?
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The enzyme plays a role in the degradation of exogenous DNA encountered by phagocytosis and is important for DNA fragmentation and degradation during cell death
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?
additional information
?
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The enzyme plays a role in the degradation of exogenous DNA encountered by phagocytosis and is important for DNA fragmentation and degradation during cell death
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?
additional information
?
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The enzyme is required for digesting DNA of apoptotic cell corpses and dietary DNA, it is not required for viability.
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?
additional information
?
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enzyme is essential to maintaining proper immune function in Drosophila
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?
additional information
?
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the enzyme is required for degrading DNA of dying cells and this function is necessary for the proper removal of apoptotic nuclei during fetal development
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?
additional information
?
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enzyme precursor Leukocyte Elastase Inhibitor is cleaved by elastase at its reactive center loop. Cleavage abolishes the antiprotease activity and leads to a conformational modification that exposes an endonuclease active site and a nuclear localization signal. Both endonuclease activity and nuclear translocation are needed to induce cell death
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?
