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Literature summary for 3.1.22.1 extracted from

  • Torriglia, A.; Lepretre, C.; Padron-Barthe, L.; Chahory, S.; Martin, E.
    Molecular mechanism of L-DNase II activation and function as a molecular switch in apoptosis (2008), Biochem. Pharmacol., 76, 1490-1502.
    View publication on PubMed
Search for more literature for 3.1.22.1

Activating Compound

Activating Compound Comment Organism Structure
AM-2282
-
 Mus musculus
AP-24 apoptotic protease of 24 kDa, is activated during apoptosis and is able to activate L-DNase II Homo sapiens
cathepsin D an acid protease, can transform LEI into L-DNase II Homo sapiens
intracellular elastase a neutral protease, can transform LEI into L-DNase II Homo sapiens
additional information activation is favoured at pH 4 but is increased by a tissue extract Homo sapiens

Application

Application Comment Organism
medicine is involved in apoptosis, LEI/LDNase II is activated mostly after metabolic stress Gallus gallus
medicine is involved in apoptosis, LEI/LDNase II is activated mostly after metabolic stress Cricetulus griseus
medicine is involved in apoptosis, LEI/LDNase II is activated mostly after metabolic stress Mus musculus
medicine is involved in apoptosis, LEI/LDNase II is activated mostly after metabolic stress Homo sapiens
medicine is involved in apoptosis, LEI/LDNase II is activated mostly after metabolic stress Rattus norvegicus

Protein Variants

Protein Variants Comment Organism
additional information mutation of the histidine moiety of His 368 completely abolishes endonuclease activity of L-DNase II Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information caspases inhibitors have no effect on acid endonucleases, and no effect on apoptosis Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus L-DNase II is translocated to the nucleus to meet its new substrate, DNA Homo sapiens 5634
-

Metals/Ions

Metals/Ions Comment Organism Structure
additional information is cation-independent Cricetulus griseus

Organism

Organism UniProt Comment Textmining
Cricetulus griseus
-
-
-
Gallus gallus
-
-
-
Homo sapiens
-
-
-
Mus musculus
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
CHO cell
-
 Cricetulus griseus
-
HeLa cell
-
 Homo sapiens
-
HL-60 cell
-
 Homo sapiens
-
L-1210 cell
-
 Mus musculus
-
lens during lens cell differentiation Homo sapiens
-
additional information F-258 cell Rattus norvegicus
-
retina is activated during development Gallus gallus
-
retina is activated in light-induced retinal degeneration Rattus norvegicus
-
spleen
-
 Homo sapiens
-
U-937 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DNA + H2O
-
 Homo sapiens 3'-phosphooligonucleotides + 5'-hydroxyoligonucleotides
-
 ?

Synonyms

Synonyms Comment Organism
acid DNase
-
 Gallus gallus
acid DNase
-
 Mus musculus
acid DNase
-
 Homo sapiens
acid DNase
-
 Rattus norvegicus
L-DNase II
-
 Gallus gallus
L-DNase II
-
 Cricetulus griseus
L-DNase II
-
 Mus musculus
L-DNase II
-
 Homo sapiens
L-DNase II
-
 Rattus norvegicus
LEI-derived DNase II
-
 Gallus gallus
LEI-derived DNase II
-
 Cricetulus griseus
LEI-derived DNase II
-
 Mus musculus
LEI-derived DNase II
-
 Homo sapiens
LEI-derived DNase II
-
 Rattus norvegicus
leukocyte elastase inhibitor-derived DNase II
-
 Gallus gallus
leukocyte elastase inhibitor-derived DNase II
-
 Cricetulus griseus
leukocyte elastase inhibitor-derived DNase II
-
 Mus musculus
leukocyte elastase inhibitor-derived DNase II
-
 Homo sapiens
leukocyte elastase inhibitor-derived DNase II
-
 Rattus norvegicus