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EC Number
Inhibitors
Commentary
Structure
3.1.22.1
2-mercaptoethanol
little effect on activity at 10 mM
3.1.22.1
actinomycin D
strong inhibition, coupling to the substrate not to the enzyme
3.1.22.1
Alkylating agents
-
3.1.22.1
aurintricarboxylic acid
-
3.1.22.1
bovine serum albumin
90% inhibition at 0.015 mg/ml, addition of inhibitor changes pH-activity curve, optimal pH shifted to the alkaline side, DNA substrate compete with inhibitor and reverses inhibitor action
3.1.22.1
Ca2+
strong inhibition
3.1.22.1
CaCl2
above 200 mM
3.1.22.1
Co2+
complete inhibition
3.1.22.1
Co2+
inhibition above 10 mM
3.1.22.1
copper sulphate
suppresses enzyme activity in hemocytes
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