2.3.1.B43: protein-lysine desuccinylase (NAD+)
This is an abbreviated version!
For detailed information about protein-lysine desuccinylase (NAD+), go to the full flat file.
Word Map on EC 2.3.1.B43
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2.3.1.B43
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sirtuins
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sirt3
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deacetylation
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deacetylases
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desuccinylation
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malonylation
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nad-dependent
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sirt1-7
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glutarylation
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diagnostics
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medicine
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drug development
- 2.3.1.B43
- sirtuins
- sirt3
-
deacetylation
- deacetylases
-
desuccinylation
-
malonylation
-
nad-dependent
-
sirt1-7
-
glutarylation
- diagnostics
- medicine
- drug development
Reaction
Synonyms
CobB, CobB Sir2 protein, histone desuccinylase, hSIRT5, hSIRT6, lysine desuccinylase, mitochondrial NAD+-dependent lysine deacylase, NAD+ dependent deacetylase, NAD+-dependent protein deacetylase, NAD+-dependent protein deacylase, NAD+-dependent sirtuin deacetylase, nicotinamide adenine dinucleotide-dependent protein deacetylase, Sir2Af1, SIRT5, SIRT5iso1, SIRT5iso2, SIRT5iso3, SIRT5iso4, sirtuin 5, sirtuin 5 deacylase, sirtuin 5 lysine deacylase, sirtuin deacylase, sirtuin-5, zSIRT5
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Source Tissue
Source Tissue on EC 2.3.1.B43 - protein-lysine desuccinylase (NAD+)
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in the cerebellar cortex, SIRT5 can be found in Purkinje cells, and is mainly distributed in the cytoplasm, but is not markedly expressed in the molecular layer or granular layer cells
SIRT5 and SIRT1/2 have opposite expression patterns and functions in macrophages, overview
SIRT5 is overexpressed in human non-small cell lung cancer cells, high expression of SIRT5 predicts poor survival
additional information
SIRT5 expression is observed to localize strictly to the periportal hepatocytes
SIRT5 displays broad tissue distribution, with highest levels in brain, heart, liver, kidney, muscle, and testis
additional information
sirtuin 5 (SIRT5) is upregulated in patients with type 2 diabetes and in pancreatic beta cell lines
additional information
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sirtuin 5 (SIRT5) is upregulated in patients with type 2 diabetes and in pancreatic beta cell lines
additional information
the SIRT5 gene is widely expressed, but expression patterns of different isoforms vary in tissues, expression analysis, overview
additional information
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the SIRT5 gene is widely expressed, but expression patterns of different isoforms vary in tissues, expression analysis, overview
additional information
SIRT5 displays broad tissue distribution, with highest levels in brain, heart, liver, kidney, muscle, and testis