2.3.1.B43: protein-lysine desuccinylase (NAD+)
This is an abbreviated version!
For detailed information about protein-lysine desuccinylase (NAD+), go to the full flat file.
Word Map on EC 2.3.1.B43
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2.3.1.B43
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sirtuins
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sirt3
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deacetylation
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deacetylases
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desuccinylation
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malonylation
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nad-dependent
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sirt1-7
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glutarylation
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diagnostics
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medicine
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drug development
- 2.3.1.B43
- sirtuins
- sirt3
-
deacetylation
- deacetylases
-
desuccinylation
-
malonylation
-
nad-dependent
-
sirt1-7
-
glutarylation
- diagnostics
- medicine
- drug development
Reaction
Synonyms
CobB, CobB Sir2 protein, histone desuccinylase, hSIRT5, hSIRT6, lysine desuccinylase, mitochondrial NAD+-dependent lysine deacylase, NAD+ dependent deacetylase, NAD+-dependent protein deacetylase, NAD+-dependent protein deacylase, NAD+-dependent sirtuin deacetylase, nicotinamide adenine dinucleotide-dependent protein deacetylase, Sir2Af1, SIRT5, SIRT5iso1, SIRT5iso2, SIRT5iso3, SIRT5iso4, sirtuin 5, sirtuin 5 deacylase, sirtuin 5 lysine deacylase, sirtuin deacylase, sirtuin-5, zSIRT5
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Localization
Localization on EC 2.3.1.B43 - protein-lysine desuccinylase (NAD+)
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additional information
SIRT5 isoforms (i.e., SIRT5iso1 and SIRT5iso2) are encoded by the human SIRT5 gene. Their C-termini slightly differ from each other. Although both isoforms contain cleavable mitochondrial targeting signals at their N-termini,it is found that the cleaved SIRT5iso2 is localized mainly in mitochondria, whereas the cleaved SIRT5iso1 is localized in both mitochondria and cytoplasm. The cytoplasmic localization of cleaved SIRT5iso1 is dependent on the SIRT5iso1-specific C-terminus
mainly distributed in the cytoplasm of Purkinje cells
SIRT5 is targeted to protein complexes on the inner mitochondrial membrane via affinity for cardiolipin
SIRT5 is targeted to protein complexes on the inner mitochondrial membrane via affinity for cardiolipin
Sirt5 can be translocated into the mitochondrial intermembrane space, but also into the matrix
SIRT5 isoforms (i.e., SIRT5iso1 and SIRT5iso2) are encoded by the human SIRT5 gene. Their C-termini slightly differ from each other. Although both isoforms contain cleavable mitochondrial targeting signals at their N-termini, it is found that the cleaved SIRT5iso2 is localized mainly in mitochondria, whereas the cleaved SIRT5iso1 is localized in both mitochondria and cytoplasm. The C-terminus of SIRT5iso2, which is rich in hydrophobic amino acid residues, functions as a mitochondrial membrane insertion signal
SIRT5 isozymes 1, 2 and 3 are mitochondria-localized. The full-length SIRT5 protein (SIRT5iso1) contains the N-terminal 36 amino acid mitochondrial localization signal (MLS) peptide
SIRT5 is present both mitochondrially and extramitochondrially
a very small amount of SIRT5 is detected in the nuclear fraction
although Sirt5 localizes mainly in the mitochondria, a slight amount of Sirt5 is detected in the nuclear fraction
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additional information
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although Sirt5 localizes mainly in the mitochondria, a slight amount of Sirt5 is detected in the nuclear fraction
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additional information
SIRT5 is predominantly a mitochondrial matrix protein, but a significant portion of SIRT5 localizes to the cytosol, peroxisomes, and nucleus as well. SIRT5 activity is non-redundant with other sirtuins in mitochondria, and likely elsewhere in the cell as well
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additional information
SIRT5 is predominantly a mitochondrial matrix protein, but a significant portion of SIRT5 localizes to the cytosol, peroxisomes, and nucleus as well. SIRT5 activity is non-redundant with other sirtuins in mitochondria, and likely elsewhere in the cell as well
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