2.3.1.B43: protein-lysine desuccinylase (NAD+)

This is an abbreviated version!
For detailed information about protein-lysine desuccinylase (NAD+), go to the full flat file.

Word Map on EC 2.3.1.B43

2.3.1.B43

sirtuins

sirt3

deacetylation

deacetylases

desuccinylation

malonylation

nad-dependent

sirt1-7

glutarylation

diagnostics

medicine

drug development

Reaction

Synonyms

CobB, CobB Sir2 protein, histone desuccinylase, hSIRT5, hSIRT6, lysine desuccinylase, mitochondrial NAD+-dependent lysine deacylase, NAD+ dependent deacetylase, NAD+-dependent protein deacetylase, NAD+-dependent protein deacylase, NAD+-dependent sirtuin deacetylase, nicotinamide adenine dinucleotide-dependent protein deacetylase, Sir2Af1, SIRT5, SIRT5iso1, SIRT5iso2, SIRT5iso3, SIRT5iso4, sirtuin 5, sirtuin 5 deacylase, sirtuin 5 lysine deacylase, sirtuin deacylase, sirtuin-5, zSIRT5

ECTree

2 Transferases

2.3 Acyltransferases

2.3.1 Transferring groups other than aminoacyl groups

2.3.1.B43 protein-lysine desuccinylase (NAD+)

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Results	in table
6	Activating Compound
7	AA Sequence
7	Application
23	Cloned(Commentary)
20	Cofactor
10	Crystallization (Commentary)
512	Disease/ Diagnostics
15	Expression
75	General Information
1	General Stability
128	IC50 Value
250	Inhibitors
38	kcat/KM [mM/s]
9	Ki Value [mM]
46	KM Value [mM]
47	Localization
2	Metals/Ions
49	Natural Substrates/ Products (Substrates)
96	Organism
12	pH Optimum
26	Protein Variants
18	Purification (Commentary)
4	Reaction
71	Reference
89	Source Tissue
156	Substrates and Products (Substrate)
2	Subunits
115	Synonyms
13	Temperature Optimum [°C]
1	Temperature Stability [°C]
44	Turnover Number [1/s]

Purification

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Purification on EC 2.3.1.B43 - protein-lysine desuccinylase (NAD+)

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8 entries

HisTrap column chromatography and Hitrap column chromatography

Homo sapiens

Q9NXA8

739445

purification of SIRT5 isozymes from HepG2 cells

Homo sapiens

Q9NXA8

755970

recombinant His-tagged enzyme from Escherichia coli strain Rosetta2(DE3) by nickel affinity chromatography and gel filtration

Homo sapiens

Q9NXA8

756010

recombinant His-tagged wild-type and mutant enzymes from Escherichia coli strain BL21(DE3) by nickel affinity chromatography

Homo sapiens

Q9NXA8

757590

recombinant N-terminally His-tagged enzyme from Escherichia coli strain BL21(DE3) by cobalt affinity chromatography, tag cleavage by TEV protease, reverse cobalt affinity chromatography, and gel filtration

Danio rerio

Q6DHI5

757400

recombinant N-terminally His-tagged enzyme from Escherichia coli strain Transetta(DE3) by nickel affinity chromatography, tag cleavage by TEV protease, and ultrafiltration

Homo sapiens

Q9NXA8

756427

recombinant N-terminally StrepII-tagged enzyme from Escherichia coli strain BL21(DE3) by affinity chromatography and gel filtration

Homo sapiens

Q9NXA8

757400