2.3.1.B43: protein-lysine desuccinylase (NAD+)

This is an abbreviated version!
For detailed information about protein-lysine desuccinylase (NAD+), go to the full flat file.

Reaction

Synonyms

CobB, CobB Sir2 protein, histone desuccinylase, hSIRT5, hSIRT6, lysine desuccinylase, mitochondrial NAD+-dependent lysine deacylase, NAD+ dependent deacetylase, NAD+-dependent protein deacetylase, NAD+-dependent protein deacylase, NAD+-dependent sirtuin deacetylase, nicotinamide adenine dinucleotide-dependent protein deacetylase, Sir2Af1, SIRT5, SIRT5iso1, SIRT5iso2, SIRT5iso3, SIRT5iso4, sirtuin 5, sirtuin 5 deacylase, sirtuin 5 lysine deacylase, sirtuin deacylase, sirtuin-5, zSIRT5

ECTree

     2 Transferases

         2.3 Acyltransferases

             2.3.1 Transferring groups other than aminoacyl groups

                2.3.1.B43 protein-lysine desuccinylase (NAD+)

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Results	in table
6	Activating Compound
7	AA Sequence
7	Application
23	Cloned(Commentary)
20	Cofactor
10	Crystallization (Commentary)
512	Disease/ Diagnostics
15	Expression
75	General Information
1	General Stability
128	IC50 Value
250	Inhibitors
38	kcat/KM [mM/s]
9	Ki Value [mM]
46	KM Value [mM]
47	Localization
2	Metals/Ions
49	Natural Substrates/ Products (Substrates)
96	Organism
12	pH Optimum
26	Protein Variants
18	Purification (Commentary)
4	Reaction
71	Reference
89	Source Tissue
156	Substrates and Products (Substrate)
2	Subunits
115	Synonyms
13	Temperature Optimum [°C]
1	Temperature Stability [°C]
44	Turnover Number [1/s]

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Application on EC 2.3.1.B43 - protein-lysine desuccinylase (NAD+)

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APPLICATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

diagnostics

Homo sapiens

Q9NXA8

elevated SIRT5 expression in human breast tumors correlates with poor patient prognosis

758247

drug development

2 entries

medicine

4 entries

drug development

Homo sapiens

Q9NXA8

SIRT5 is a drug target

756522

drug development

Homo sapiens

Q9NXA8

Sirt5 is a potential drug target for the treatment of cancer, Alzheimer's disease, and Parkinson's disease

757350

medicine

Rattus norvegicus

Q68FX9

pharmacological interventions on SIRT5 expression may be useful in the treatment of oxidative stress-related cardiac injury

729556

medicine

Homo sapiens

Q9NXA8

SIRT5 is involved in influencing oocyte quality and in-vitro-fertilisation outcomes

730922

medicine

Mus musculus

Q8K2C6

SIRT5 may have therapeutic value to treat hyperammonemia

728932

medicine

Homo sapiens

Q9NXA8

SIRT5 may serve as a potential prognostic factor and drug target for intervention in non-small cell lung cancer. SIRT5 is overexpressed in human non-small cell lung cancer cells, high expression of SIRT5 predicts poor survival. SIRT5 knockdown makes lung cancer cells more sensitive to drug (cis-diamminedichloroplatinum, 5-fluorouracil or bleomycin) treatment in vitro and in vivo. Nrf2, which is a core transcription factor for lung cancer growth and drug resistance, is a target of SIRT5

731010