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2.3.1.B43: protein-lysine desuccinylase (NAD+)

This is an abbreviated version!
For detailed information about protein-lysine desuccinylase (NAD+), go to the full flat file.

Word Map on EC 2.3.1.B43

Reaction

NAD+
+
[protein]-N6-acetyl-L-lysine
=
nicotinamide
 +
[protein]-L-lysine
 +
2'-O-acetyl-ADP-ribose

Synonyms

CobB, CobB Sir2 protein, histone desuccinylase, hSIRT5, hSIRT6, lysine desuccinylase, mitochondrial NAD+-dependent lysine deacylase, NAD+ dependent deacetylase, NAD+-dependent protein deacetylase, NAD+-dependent protein deacylase, NAD+-dependent sirtuin deacetylase, nicotinamide adenine dinucleotide-dependent protein deacetylase, Sir2Af1, SIRT5, SIRT5iso1, SIRT5iso2, SIRT5iso3, SIRT5iso4, sirtuin 5, sirtuin 5 deacylase, sirtuin 5 lysine deacylase, sirtuin deacylase, sirtuin-5, zSIRT5

ECTree

     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.B43 protein-lysine desuccinylase (NAD+)

KM Value

KM Value on EC 2.3.1.B43 - protein-lysine desuccinylase (NAD+)

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.084
Ac-(N6-succinyl)Lys-7-amido-4-methylcoumarin
pH 8.0, 37°C
0.033
Ac-Leu-Gly-(N6-succinyl)Lys-7-amido-4-methylcoumarin
pH 8.0, 37°C
0.0243
benzoyl-GVL(N6-acetyl)KEYGV-amide
pH 7.8, 37°C
0.0065
benzoyl-GVL(N6-adipoyl)KEYGV-amide
pH 7.8, 37°C
0.0041
benzoyl-GVL(N6-glutaryl)KEYGV-amide
pH 7.8, 37°C
0.0051
benzoyl-GVL(N6-malonyl)KEYGV-amide
pH 7.8, 37°C
0.416
benzoyl-GVL(N6-oxalyl)KEYGV-amide
pH 7.8, 37°C
0.0805
benzoyl-GVL(N6-pimeloyl)KEYGV-amide
pH 7.8, 37°C
0.409
benzoyl-GVL(N6-suberoyl)KEYGV-amide
pH 7.8, 37°C
0.0038
benzoyl-GVL(N6-succinyl)KEYGV-amide
pH 7.8, 37°C
0.0058
KQTAR(N6-malonyl)KSTGGWW
pH 7.5, 37°C
0.0061
KQTAR(N6-succinyl)KSTGGWW
pH 7.5, 37°C
0.45
KTRSG(N6-malonyl)KVMRRWW
pH 7.5, 37°C
0.15
KTRSG(N6-succinyl)KVMRRWW
pH 7.5, 37°C
0.069 - 1.605
NAD+
0.014
SGASE(N6-malonyl)KDIVHSGWW
pH 7.5, 37°C
0.0087
SGASE(N6-succinyl)KDIVHSGWW
pH 7.5, 37°C
0.08018
[histone H2A]-N6-succinyl-L-lysine95
pH 7.5, 37°C, recombinant enzyme
-
0.10228
[histone H2A]-N6-succinyl-L-lysine9_(4-15)-A10G peptide
pH 7.5, 37°C, recombinant enzyme
-
0.06173
[histone H2B]-N6-succinyl-L-lysine116
pH 7.5, 37°C, recombinant enzyme
-
0.08777
[histone H2B]-N6-succinyl-L-lysine120
pH 7.5, 37°C, recombinant enzyme
-
0.09973
[histone H2B]-N6-succinyl-L-lysine34
pH 7.5, 37°C, recombinant enzyme
-
0.0147 - 0.02
[histone H3 K9 peptide]-N6-acetyl-L-lysine
-
0.086
[histone H3 K9 peptide]-N6-succinyl-L-lysine
-
pH 8.0, 37°C, wild-type enzyme
-
0.06051
[histone H3]-N6-succinyl-L-lysine122
pH 7.5, 37°C, recombinant enzyme
-
0.09551
[histone H3]-N6-succinyl-L-lysine14
pH 7.5, 37°C, recombinant enzyme
-
0.10442
[histone H3]-N6-succinyl-L-lysine14_(9-20)-A15G peptide
pH 7.5, 37°C, recombinant enzyme
-
0.17932
[histone H3]-N6-succinyl-L-lysine56
pH 7.5, 37°C, recombinant enzyme
-
0.08489
[histone H3]-N6-succinyl-L-lysine79
pH 7.5, 37°C, recombinant enzyme
-
0.07717
[histone H3]-N6-succinyl-L-lysine9
pH 7.5, 37°C, recombinant enzyme
-
0.10072
[histone H4]-N6-succinyl-L-lysine12
pH 7.5, 37°C, recombinant enzyme
-
0.13153
[histone H4]-N6-succinyl-L-lysine31
pH 7.5, 37°C, recombinant enzyme
-
0.06583
[histone H4]-N6-succinyl-L-lysine31_(26-37)-P32A peptide
pH 7.5, 37°C, recombinant enzyme
-
0.08268
[histone H4]-N6-succinyl-L-lysine77
pH 7.5, 37°C, recombinant enzyme
-
0.10178
[histone H4]-N6-succinyl-L-lysine91
pH 7.5, 37°C, recombinant enzyme
-
0.72
[protein]-N6-acetyl-L-lysine
mutant enzyme Y102A, at 8.0 pH and 25°C
0.29 - 1.658
[protein]-N6-succinyl-L-lysine