Literature summary for 2.3.1.B43 extracted from

Liu, B.; Che, W.; Zheng, C.; Liu, W.; Wen, J.; Fu, H.; Tang, K.; Zhang, J.; Xu, Y.
SIRT5: a safeguard against oxidative stress-induced apoptosis in cardiomyocytes (2013), Cell. Physiol. Biochem., 32, 1050-1059.

Search for more literature for 2.3.1.B43

Application

Application	Comment	Organism
medicine	pharmacological interventions on SIRT5 expression may be useful in the treatment of oxidative stress-related cardiac injury	Rattus norvegicus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
mitochondrion	-	Rattus norvegicus	5739	-

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	Q68FX9	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
H9c2 cell	-	Rattus norvegicus	-

Synonyms

Synonyms	Comment	Organism
SIRT5	-	Rattus norvegicus

Expression

Organism	Comment	Expression
Rattus norvegicus	SIRT5 is significantly down-regulated in cardiomyocytes upon oxidative stress	down

General Information

General Information	Comment	Organism
malfunction	SIRT5 knockdown in cardiomyocytes results in a marked reduction in cell viability, and a significant increase in the number of apoptotic cells	Rattus norvegicus
metabolism	SIRT5 is involved in the regulation of oxidative stress induced apoptosis in cardiomyocytes	Rattus norvegicus

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Release 2023.1 (January 2023)