Cloned (Comment) | Organism |
---|---|
SIRT5 isozymes, DNA and amino acid sequence determination and analysis | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | SIRT5 isozyme 4 is mainly localized in the cytoplasm | Homo sapiens | 5737 | - |
mitochondrion | SIRT5 isozymes 1, 2 and 3 are mitochondria-localized. The full-length SIRT5 protein (SIRT5iso1) contains the N-terminal 36 amino acid mitochondrial localization signal (MLS) peptide | Homo sapiens | 5739 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9NXA8 | - |
- |
Purification (Comment) | Organism |
---|---|
purification of SIRT5 isozymes from HepG2 cells | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
16-HBE14o cell | - |
Homo sapiens | - |
A-549 cell | - |
Homo sapiens | - |
adipose tissue | - |
Homo sapiens | - |
bladder | - |
Homo sapiens | - |
blood | - |
Homo sapiens | - |
bone | - |
Homo sapiens | - |
brain | - |
Homo sapiens | - |
connective tissue | - |
Homo sapiens | - |
embryo | - |
Homo sapiens | - |
esophagus | - |
Homo sapiens | - |
eye | - |
Homo sapiens | - |
heart | - |
Homo sapiens | - |
HEK-293T cell | - |
Homo sapiens | - |
HeLa cell | - |
Homo sapiens | - |
Hep-G2 cell | - |
Homo sapiens | - |
HHL-5 cell | - |
Homo sapiens | - |
HL-7702 cell | - |
Homo sapiens | - |
hypophysis | - |
Homo sapiens | - |
intestine | - |
Homo sapiens | - |
K-562 cell | - |
Homo sapiens | - |
kidney | - |
Homo sapiens | - |
liver | - |
Homo sapiens | - |
lung | - |
Homo sapiens | - |
lymph node | - |
Homo sapiens | - |
mammary gland | - |
Homo sapiens | - |
additional information | the SIRT5 gene is widely expressed, but expression patterns of different isoforms vary in tissues, expression analysis, overview | Homo sapiens | - |
mouth | - |
Homo sapiens | - |
NCI-H1299 cell | - |
Homo sapiens | - |
neuron | SIRT5 isozyme 2 | Homo sapiens | - |
pancreas | - |
Homo sapiens | - |
placenta | - |
Homo sapiens | - |
prostate gland | - |
Homo sapiens | - |
skin | - |
Homo sapiens | - |
stomach | - |
Homo sapiens | - |
testis | - |
Homo sapiens | - |
thymus | - |
Homo sapiens | - |
thyroid gland | - |
Homo sapiens | - |
trachea | - |
Homo sapiens | - |
uterine cervix | - |
Homo sapiens | - |
uterus | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | synthsis of substrate peptide (2-Abz)-GVLK (succ)A [Y (3-NO2)]GV-NH2 | Homo sapiens | ? | - |
- |
Subunits | Comment | Organism |
---|---|---|
? | x * 34000, isozyme SIRT5iso1, SDS-PAGE | Homo sapiens |
More | the full-length SIRT5 protein (SIRT5iso1) contains the N-terminal 36 amino acid mitochondrial localization signal peptide and the remaining NAD+-dependent deacylase domain | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
SIRT5 | - |
Homo sapiens |
SIRT5iso1 | - |
Homo sapiens |
SIRT5iso2 | - |
Homo sapiens |
SIRT5iso3 | - |
Homo sapiens |
SIRT5iso4 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | - |
assay at | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
evolution | SIRT5 gene encodes for four SIRT5 protein isoforms, namely SIRT5iso1, SIRT5iso2, SIRT5iso3, and SIRT5iso4 | Homo sapiens |
physiological function | potential role of isozyme SIRT5iso2 in neuron system | Homo sapiens |