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Literature summary for 2.3.1.B43 extracted from

  • Zhou, L.; Wang, F.; Sun, R.; Chen, X.; Zhang, M.; Xu, Q.; Wang, Y.; Wang, S.; Xiong, Y.; Guan, K.L.; Yang, P.; Yu, H.; Ye, D.
    SIRT5 promotes IDH2 desuccinylation and G6PD deglutarylation to enhance cellular antioxidant defense (2016), EMBO Rep., 17, 811-822.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.1.B43

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
NAD+ + [glucose-6-phosphate dehydrogenase]-N6-acetyl-L-lysine Mus musculus
-
 nicotinamide + [glucose-6-phosphate dehydrogenase]-L-lysine + 2'-O-acetyl-ADP-ribose
-
 ?
NAD+ + [isocitrate dehydrogenase 2]-N6-acetyl-L-lysine Mus musculus
-
 nicotinamide + [isocitrate dehydrogenase 2]-L-lysine + 2'-O-acetyl-ADP-ribose
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
MEF cell
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NAD+ + [glucose-6-phosphate dehydrogenase]-N6-acetyl-L-lysine
-
 Mus musculus nicotinamide + [glucose-6-phosphate dehydrogenase]-L-lysine + 2'-O-acetyl-ADP-ribose
-
 ?
NAD+ + [isocitrate dehydrogenase 2]-N6-acetyl-L-lysine
-
 Mus musculus nicotinamide + [isocitrate dehydrogenase 2]-L-lysine + 2'-O-acetyl-ADP-ribose
-
 ?

Synonyms

Synonyms Comment Organism
SIRT5
-
 Mus musculus

Expression

Organism Comment Expression
Mus musculus the enzyme expression is not affected by chemical oxidant treatment additional information

General Information

General Information Comment Organism
malfunction knockdown or knockout of the enzyme leads to high levels of cellular reactive oxygen species. SIRT5 inactivation leads to the inhibition of isocitrate dehydrogenase 2 and glucose-6-phosphate dehydrogenase, thereby decreasing NADPH production, lowering GSH, impairing the ability to scavenge ROS, and increasing cellular susceptibility to oxidative stress Mus musculus