Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
NAD+ + [forkhead box O3]-N6-acetyl-L-lysine | Homo sapiens | the enzyme deacetylates FOXO3 at K271 and K290 | nicotinamide + [forkhead box O3]-L-lysine + 2'-O-acetyl-ADP-ribose | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
A-549 cell | - |
Homo sapiens | - |
lung epithelial cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
NAD+ + [forkhead box O3]-N6-acetyl-L-lysine | the enzyme deacetylates FOXO3 at K271 and K290 | Homo sapiens | nicotinamide + [forkhead box O3]-L-lysine + 2'-O-acetyl-ADP-ribose | - |
? |
Synonyms | Comment | Organism |
---|---|---|
NAD+-dependent protein deacetylase | - |
Homo sapiens |
nicotinamide adenine dinucleotide-dependent protein deacetylase | - |
Homo sapiens |
SIRT5 | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | cigarette smoke extract induces the enzyme | up |
General Information | Comment | Organism |
---|---|---|
physiological function | the enzyme prevents cigarette smoke extract-induced apoptosis in lung epithelial cells via deacetylation of FOXO3 | Homo sapiens |