Reference on EC 3.2.2.5 - NAD+ glycohydrolase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Okayama, H.; Ueda, K.; Hayaishi, O.
NAD glycohydrolases from rat liver nuclei
Methods Enzymol.
66
151-154
1986
Rattus norvegicus
Anderson, B.M.; Yuan, J.H.
NAD glycohydrolase from bovine seminal plasma
Methods Enzymol.
66
144-150
1986
Bos taurus
Everse, K.E.; Everse, J.; Simeral, L.S.
Bacillus subtilis NADase and its specific protein inhibitor
Methods Enzymol.
66
137-144
1986
Bacillus subtilis
Anderson, B.M.; Yost, D.A.; Anderson, C.D.
Snake venom NAD glycohydrolase: purification, immobilization, and transglycosidation
Methods Enzymol.
122
173-181
1986
Bungarus fasciatus
Stathakos, D.; Isaakidou, I.; Thomou, H.
Purification and properties of NAD nucleosidase from Fusarium nivale
Biochim. Biophys. Acta
302
80-89
1973
Microdochium nivale
Huang, W.Z.; Wang, C.; Luo, L.Q.; Lu, Z.X.
Properties of NAD-glycohydrolase purified from five-pace snake (Agkistrodon acutus) venom
Toxicon
26
535-542
1988
Deinagkistrodon acutus
Price, S.R.; Pekala, P.H.
Pyridine nucleotide-linked glycohydrolases
Coenzymes and cofactors, Glutathione, Chem. Biochem. Med. Aspects Pt. A (Dolphin D, Poulson R, Avromonic O, eds. ) John Wiley & Sons, New York
2
514-548
1989
Bacillus subtilis, Bos taurus, Bungarus fasciatus, Mycobacterium tuberculosis, Neurospora crassa, Pseudomonas putida, Rattus norvegicus, Streptococcus pyogenes, Sus scrofa
-
Zahradnik, F.J.
Streptococcal extracellular NAD+ nucleosidase. Characterization of changes occuring during purification
Folia Microbiol. (Praha)
25
40-49
1980
Streptococcus pyogenes
Davis, W.B.
Identification of a nicotinamide adenine dinucleotide glycohydrolase and an associated inhibitor in isoniazid-susceptible and -resistant Mycobacterium phlei
Antimicrob. Agents Chemother.
17
663-668
1980
Mycolicibacterium phlei
Schuber, F.; Muller, H.; Schenherr, I.
Amphipathic properties of calf spleen NAD glycohydrolase
FEBS Lett.
109
247-251
1980
Bos taurus
Fernandes, P.B.; Welsh, K.M.; Bayer, M.E.
Characterization of membrane-bound nicotinamide adenine dinucleotide glycohydrolase of Vibrio cholerae
J. Biol. Chem.
254
9254-9261
1979
Vibrio cholerae serotype O1
Travo, P.; Muller, H.; Schuber, F.
Calf spleen NAD glycohydrolase
Eur. J. Biochem.
96
141-149
1979
Bos taurus
Diaugustine, R.P.; Abe, T.; Voytek, P.
Purification and comparative properties of the glycoprotein nicotinamide adenine dinucleotide glycohydrolase from rat liver microsomal and plasma membranes
Biochim. Biophys. Acta
526
518-530
1978
Rattus norvegicus
Schuber, F.; Pascal, M.; Travo, P.
Calf-spleen nicotinamide-adenine dinucleotide glycohydrolase
Eur. J. Biochem.
83
205-214
1978
Bos taurus
Pekala, P.H.; Anderson, B.M.
Studies of bovine erythrocyte NAD glycohydrolase
J. Biol. Chem.
253
7453-7459
1978
Bos taurus
Fukushima, M.; Okayama, H.; Takahashi, Y.; Hayaishi, O.
Characterization of the NAD glycohydrolase associated with the rat liver nuclear envelope
J. Biochem.
80
167-176
1976
Rattus norvegicus
Schuber, F.; Travo, P.
Calf-spleen nicotinamide-adenine dinucleotide glycohydrolase
Eur. J. Biochem.
65
247-255
1976
Bos taurus
Ueda, K.; Fukushima, M.; Okayama, H.; Hayaishi, O.
Nicotinamide adenine dinucleotide glycohydrolase from rat liver nuclei
J. Biol. Chem.
250
7541-7546
1975
Rattus norvegicus
Everse, J.; Everse, K.E.; Kaplan, N.O.
The pyridine nucleosidase from Bacillus subtilis and Neurospora crassa
Arch. Biochem. Biophys.
169
702-713
1975
Bacillus subtilis, Neurospora crassa
Grushoff, P.S.; Shany, S.; Bernheimer, A.W.
Purification and properties of Streptococcal nicotinamide adenin dinucleotide glycohydrolase
J. Bacteriol.
122
599-605
1975
Streptococcus pyogenes
Mellors, A.; Lun, A.K.L.; Peled, O.N.
Evidence for NAD nucleosidase in rabbit-liver lysosomes
Can. J. Biochem.
53
143-148
1975
Oryctolagus cuniculus
Green, S.; Dobrjansky, A.
Nicotinamide adenine dinucleotide glycohydrolases from Ehrlich ascites tumor cell nuclei: isolation, partial purification and properties
Biochemistry
11
4108-4113
1972
Mus musculus
Yuan, J.H.; Barnett, L.B.; Anderson, B.M.
Bull semen nicotinamide adenine dinucleotide nucleosidase II Physical and chemical studies
J. Biol. Chem.
247
511-514
1972
Bos taurus
Yuan, J.H.; Anderson, B.M.
Bull semen nicotinamide adenine dinucleotide nucleosidase III Properties of the substrate binding site
J. Biol. Chem.
247
515-520
1972
Bos taurus
Nakazawa, K.; Ueda, K.; Honjo, T.; Yoshihara, K.; Nishizuka, Y.; Hayaishi, O.
Nicotinamide adenine dinucleotide glycohydrolases and poly adenosine diphosphate ribose synthesis in rat liver
Biochem. Biophys. Res. Commun.
32
143-194
1968
Rattus norvegicus
De Wolf, M.J.S.; van Dessel, G.A.F.; Lagrou, A.R.; Hilderson, H.J.J.; Dierick, W.S.H.
Topography, purification and characterization of thyroidal NAD+ glycohydrolase
Biochem. J.
226
415-427
1985
Bos taurus
Anderson, B.M.; Anderson, C.D.
Properties and applications of immobilized snake venom NAD glycohydrolase
Anal. Biochem.
140
250-255
1984
Bungarus fasciatus
Moser, B.; Winterhalter, K.H.; Richter, C.
Purification and properties of a mitochondrial NAD+ glycohydrolase
Arch. Biochem. Biophys.
224
358-364
1983
Rattus norvegicus
Yost, D.A.; Anderson, B.M.
Purification and properties of the soluble NAD glycohydrolase from Bungaris fascilatus venom
J. Biol. Chem.
256
3647-3653
1981
Bungarus fasciatus
Menegus, F.; Pace, M.
Purification and some properties of NAD-glycohydrolase from conidia of Neurospora crassa
Eur. J. Biochem.
113
485-490
1981
Neurospora crassa
Wall, K.A.; Klis, M.; Kornet, J.; Coyle, D.; Ame, J.C.; Jacobson, M.K.; Slama, J.T.
Inhibition of the intrinsic NAD+ glycohydrolase activity of CD38 by carbocyclic NAD analougues
Biochem. J.
335
631-636
1998
Canis lupus familiaris, Homo sapiens, Mus musculus
-
Gerlach, D.; Ozegowski, J.H.; Gunther, E.; Vettermann, S.; Khler, W.
Studies on streptococcal NAD-glycohydrolase
Adv. Exp. Med. Biol.
418
601-603
1997
Streptococcus pyogenes
Pace, M.; Agnellini, D.; Lippoli, G.; Berger, R.L.
Hydrophobic properties of NAD glycohydrolase from Neurospora crassa conidia and interaction with dioxane
Adv. Exp. Med. Biol.
419
389-397
1997
Neurospora crassa
Hellmich, M.R.; Strumwasser, F.
Purification and characterization of a molluscan egg-specific NADase, a second messenger enzyme
Cell Regul.
2
193-202
1991
Aplysia californica
Jorcke, D.; Ziegler, M.; Schweiger, M.
Characteriation of hydrosoluble and detergent-solubilized forms of mitochondrial NAD+ glycohydrolase from bovine liver
Adv. Exp. Med. Biol.
419
447-451
1997
Bos taurus
Ziegler, M.; Jorcke, D.; Zhang, J.; Schneider, R.; Klocker, H.; Auer, B.; Schweiger, M.
Characterization of detergent-solubilized beef liver mitochondrial NAD+ glycohydrolase and its truncated hydrosoluble form
Biochemistry
35
5207-5212
1996
Bos taurus
Cho, Y.S.; Han, M.K.; Kwark, O.S.; Phoe, M.S.; Cha, Y.S.; An, N.H.; Kim, U.H.
Auto-ADP-ribosylation of NAD glycohydrolase from Neurospora crassa
Comp. Biochem. Physiol. B
120
175-181
1998
Neurospora crassa
Muller-Steffner, H.; Slama, J.; Schuber, F.
Photodependent inhibition of bovine spleen NAD+ glycohydrolase by 8-azido carbocyclic analogs of NAD+
Biochem. Biophys. Res. Commun.
228
128-133
1996
Bos taurus
Penyige, A.; Deak, E.; Kalmanczhelyi, A.; Barabas, G.
Evidence of a role for NAD+-glycohydrolase and ADP-ribosyltransferase in growth and differentiation of Streptomyces griseus NRRL B-2682: inhibition by m-aminophenylboronic acid
Microbiology
142
1937-1944
1996
Streptomyces griseus, Streptomyces griseus NRRL B-2682
-
Muller-Steffner, H.; Schenherr-Gusse, I.; Tarnus, C.; Schuber, F.
Calf spleen NAD+ glycohydrolase: solubilization, purification, and properties of the intact form of the enzyme
Arch. Biochem. Biophys.
304
154-162
1993
Bos taurus
Kim, U.H.; Kim, M.K.; Kim, J.S.; Han, M.K.; Park, B.H.; Kim, H.R.
Purification and characterization of NAD glycohydrolase from rabbit erythrocytes
Arch. Biochem. Biophys.
305
147-152
1993
Oryctolagus cuniculus
Zhang, J.; Ziegler, M.; Schneider, R.; Klocker, H.; Auer, B.; Schweiger, M.
Identification and purification of a bovine liver mitochondrial NAD+-glycohydrolase
FEBS Lett.
377
530-534
1995
Bos taurus
Muller-Steffner, H.; Malver, O.; Hosie, L.; Oppenheimer, N.J.; Schuber, F.
Slow-binding inhibition of NAD+ glycohydrolase by arabino analogues of beta-NAD+
J. Biol. Chem.
267
9606-9611
1992
Bos taurus
Hara-Yokoyama, M.; Kukimoto, I.; Nishina, H.; Kontani, K.; Hirabayashi, Y.; Irie, F.; Sugiya, H.; Furuyama, S.; Katada, T.
Inhibition of NAD+ glycohydrolase and ADP-ribosyl cyclase activities of leukocyte cell surface antigen CD38 by gangliosides
J. Biol. Chem.
271
12951-12955
1996
Homo sapiens
Zocchi, E.; Franco, L.; Guida, L.; Benatti, U.; Bargellesi, A.; Malavasi, F.; Lee, H.C.; de Flora, A.
A single protein immunologically identified as CD38 displays NAD+ glycohydrolase, ADP-ribosyl cyclase and cyclic ADP-ribose hydrolase activities at the outer surface of human erythrocytes
Biochem. Biophys. Res. Commun.
196
1459-1465
1993
Homo sapiens
Hara-Yokoyama, M.; Nagatsuka, Y.; Katsumata, O.; Irie, F.; Kontani, K.; Hoshino, S.; Katada, T.; Ono, Y.; Fujita-Yoshigaki, J.; Sugiya, H.; Furuyama, S.; Hirabayashi, Y.
Complex gangliosides as cell surface inhibitors for the ecto-NAD+ glycohydrolase of CD38
Biochemistry
40
888-895
2001
Homo sapiens
Tono-Oka, S.; Hatakeyama, M.
Unusual enzymatic hydrolysis of NAD by solubilized form of NAD(+) glycohydrolase
Chem. Pharm. Bull.
50
831-833
2002
Sus scrofa
Stabb, E.V.; Reich, K.A.; Ruby, E.G.
Vibrio fischeri genes hvnA and hvnB encode secreted NAD(+)-glycohydrolases
J. Bacteriol.
183
309-317
2001
Aliivibrio fischeri (Q56685), Aliivibrio fischeri (Q9F0R5), Aliivibrio fischeri
Ceni, C.; Muller-Steffner, H.; Lund, F.; Pochon, N.; Schweitzer, A.; De Waard, M.; Schuber, F.; Villaz, M.; Moutin, M.J.
Evidence for an intracellular ADP-ribosyl cyclase/NAD+-glycohydrolase in brain from CD38-deficient mice
J. Biol. Chem.
278
40670-40678
2003
Mus musculus
Bortell, R.; Moss, J.; McKenna, R.C.; Rigby, M.R.; Niedzwiecki, D.; Stevens, L.A.; Patton, W.A.; Mordes, J.P.; Greiner, D.L.; Rossini, A.A.
Nicotinamide adenine dinucleotide (NAD) and its metabolites inhibit T lymphocyte proliferation: role of cell surface NAD glycohydrolase and pyrophosphatase activities
J. Immunol.
167
2049-2059
2001
Rattus norvegicus
Zielinska, W.; Barata, H.; Chini, E.N.
Metabolism of cyclic ADP-ribose: Zinc is an endogenous modulator of the cyclase/NAD glycohydrolase ratio of a CD38-like enzyme from human seminal fluid
Life Sci.
74
1781-1790
2004
Homo sapiens
Balducci, E.; Micossi, L.G.
NAD-dependent inhibition of the NAD-glycohydrolase activity in A549 cells
Mol. Cell. Biochem.
233
127-132
2002
Homo sapiens
Bricker, A.L.; Cywes, C.; Ashbaugh, C.D.; Wessels, M.R.
NAD+-glycohydrolase acts as an intracellular toxin to enhance the extracellular survival of group A streptococci
Mol. Microbiol.
44
257-269
2002
Streptococcus sp., Streptococcus sp. 3
Wu, S.D.; Liu, Y.; Xu, X.; Zhu, Z.
Purification of NAD glycohydrolase from Agkistrodon acutus venom
Protein Expr. Purif.
25
319-322
2002
Deinagkistrodon acutus
Kimoto, H.; Fujii, Y.; Yokota, Y.; Taketo, A.
Molecular characterization of NADase-streptolysin O operon of hemolytic streptococci
Biochim. Biophys. Acta
1681
134-149
2005
Streptococcus pyogenes
Albeniz, I.; Demir, O.; Nurten, R.; Bermek, E.
NAD glycohydrolase activities and ADP-ribose uptake in erythrocytes from normal subjects and cancer patients
Biosci. Rep.
24
41-53
2004
Homo sapiens
Moreno-Garcia, M.E.; Partida-Sanchez, S.; Primack, J.; Sumoza-Toledo, A.; Muller-Steffner, H.; Schuber, F.; Oppenheimer, N.; Lund, F.E.; Santos-Argumedo, L.
CD38 is expressed as noncovalently associated homodimers on the surface of murine B lymphocytes
Eur. J. Biochem.
271
1025-1034
2004
Mus musculus
Bricker, A.L.; Carey, V.J.; Wessels, M.R.
Role of NADase in virulence in experimental invasive group A streptococcal infection
Infect. Immun.
73
6562-6566
2005
Streptococcus pyogenes
Michos, A.; Gryllos, I.; Hakansson, A.; Srivastava, A.; Kokkotou, E.; Wessels, M.R.
Enhancement of streptolysin O activity and intrinsic cytotoxic effects of the group A streptococcal toxin, NAD-glycohydrolase
J. Biol. Chem.
281
8216-8223
2006
Streptococcus pyogenes
Kimoto, H.; Fujii, Y.; Hirano, S.; Yokota, Y.; Taketo, A.
Genetic and biochemical properties of streptococcal NAD-glycohydrolase inhibitor
J. Biol. Chem.
281
9181-9189
2006
Streptococcus dysgalactiae subsp. equisimilis
Krebs, C.; Adriouch, S.; Braasch, F.; Koestner, W.; Leiter, E.H.; Seman, M.; Lund, F.E.; Oppenheimer, N.; Haag, F.; Koch-Nolte, F.
CD38 controls ADP-ribosyltransferase-2-catalyzed ADP-ribosylation of T cell surface proteins
J. Immunol.
174
3298-3305
2005
Mus musculus
Moreno-Garcia, M.E.; Sumoza-Toledo, A.; Lund, F.E.; Santos-Argumedo, L.
Localization of CD38 in murine B lymphocytes to plasma but not intracellular membranes [published erratum appears in Mol. Immunol., 42; 1417 (2005)]
Mol. Immunol.
42
703-711
2005
Mus musculus
Smyth, L.M.; Breen, L.T.; Yamboliev, I.A.; Mutafova-Yambolieva, V.N.
Novel localization of CD38 in perivascular sympathetic nerve terminals
Neuroscience
139
1467-1477
2006
Canis lupus familiaris
Iqbal, J.; Zaidi, M.
CD38 is required for priming by TNF-alpha: a mechanism for extracellular coordination of cell fate
Am. J. Physiol. Renal Physiol.
292
F1283-F1290
2007
Mus musculus
Sawai, J.; Hasegawa, T.; Kamimura, T.; Okamoto, A.; Ohmori, D.; Nosaka, N.; Yamada, K.; Torii, K.; Ohta, M.
Growth phase-dependent effect of clindamycin on production of exoproteins by Streptococcus pyogenes
Antimicrob. Agents Chemother.
51
461-467
2007
Streptococcus pyogenes
Iqbal, J.; Zaidi, M.
Extracellular NAD+ metabolism modulates osteoclastogenesis
Biochem. Biophys. Res. Commun.
349
533-539
2006
Mus musculus
Ceni, C.; Pochon, N.; Villaz, M.; Muller-Steffner, H.; Schuber, F.; Baratier, J.; De Waard, M.; Ronjat, M.; Moutin, M.J.
The CD38-independent ADP-ribosyl cyclase from mouse brain synaptosomes: a comparative study of neonate and adult brain
Biochem. J.
395
417-426
2006
Mus musculus
Zhang, B.; Muller-Steffner, H.; Schuber, F.; Potter, B.V.
Nicotinamide 2-fluoroadenine dinucleotide unmasks the NAD+ glycohydrolase activity of Aplysia californica adenosine 5-diphosphate ribosyl cyclase
Biochemistry
46
4100-4109
2007
Aplysia californica
Ortolan, E.; Tibaldi, E.V.; Ferranti, B.; Lavagno, L.; Garbarino, G.; Notaro, R.; Luzzatto, L.; Malavasi, F.; Funaro, A.
CD157 plays a pivotal role in neutrophil transendothelial migration
Blood
108
4214-4222
2006
Homo sapiens
Kirchberger, T.; Wagner, G.; Xu, J.; Cordiglieri, C.; Wang, P.; Gasser, A.; Fliegert, R.; Bruhn, S.; Fluegel, A.; Lund, F.E.; Zhang, L.H.; Potter, B.V.; Guse, A.H.
Cellular effects and metabolic stability of N1-cyclic inosine diphosphoribose and its derivatives
Br. J. Pharmacol.
149
337-344
2006
Neurospora crassa
Hara-Yokoyama, M.; Kimura, T.; Kaku, H.; Wakiyama, M.; Kaitsu, Y.; Inoue, M.; Kusano, S.; Shirouzu, M.; Yokoyama, S.; Katada, T.; Hirabayashi, Y.; Takatsu, K.; Yanagishita, M.
Alteration of enzymatic properties of cell-surface antigen CD38 by agonistic anti-CD38 antibodies that prolong B cell survival and induce activation
Int. Immunopharmacol.
8
59-70
2008
Mus musculus
Liu, Q.; Kriksunov, I.A.; Graeff, R.; Munshi, C.; Lee, H.C.; Hao, Q.
Structural basis for the mechanistic understanding of human CD38-controlled multiple catalysis
J. Biol. Chem.
281
32861-32869
2006
Homo sapiens
Liu, Q.; Kriksunov, I.A.; Moreau, C.; Graeff, R.; Potter, B.V.; Lee, H.C.; Hao, Q.
Catalysis-associated conformational changes revealed by human CD38 complexed with a non-hydrolyzable substrate analog
J. Biol. Chem.
282
24825-24832
2007
Homo sapiens (P28907)
Rah, S.Y.; Park, K.H.; Nam, T.S.; Kim, S.J.; Kim, H.; Im, M.J.; Kim, U.H.
Association of CD38 with nonmuscle myosin heavy chain IIA and Lck is essential for the internalization and activation of CD38
J. Biol. Chem.
282
5653-5660
2007
Homo sapiens
Partida-Sanchez, S.; Gasser, A.; Fliegert, R.; Siebrands, C.C.; Dammermann, W.; Shi, G.; Mousseau, B.J.; Sumoza-Toledo, A.; Bhagat, H.; Walseth, T.F.; Guse, A.H.; Lund, F.E.
Chemotaxis of mouse bone marrow neutrophils and dendritic cells is controlled by ADP-ribose, the major product generated by the CD38 enzyme reaction
J. Immunol.
179
7827-7839
2007
Mus musculus
Lasko, D.; McKerracher, L.
Fluorescent assay of cell-permeable C3 transferase activity
Methods Enzymol.
406
512-520
2006
Escherichia coli
Ghosh, J.; Caparon, M.G.
Specificity of Streptococcus pyogenes NAD(+) glycohydrolase in cytolysin-mediated translocation
Mol. Microbiol.
62
1203-1214
2006
Streptococcus pyogenes
Minami, M.; Kamimura, T.; Isaka, M.; Tatsuno, I.; Ohta, M.; Hasegawa, T.
Clindamycin-induced CovS-mediated regulation of the production of virulent exoproteins streptolysin O, NAD glycohydrolase, and streptokinase in Streptococcus pyogenes
Antimicrob. Agents Chemother.
54
98-102
2010
Streptococcus pyogenes
Zhang, L.; Xu, X.; Luo, Z.; Shen, D.; Wu, H.
Identification of an unusual AT(D)Pase-like activity in multifunctional NAD glycohydrolase from the venom of Agkistrodon acutus
Biochimie
91
240-251
2009
Deinagkistrodon acutus
Zhang, L.Y.; Xu, X.L.; Luo, Z.F.; Wu, H.; Shen, D.K.; Peng, L.L.; Liu, Y.Z.
Small-molecule reductants inhibit multicatalytic activity of AA-NADase from Agkistrodon acutus venom by reducing the disulfide-bonds and Cu(II) of enzyme
Biopolymers
93
141-149
2010
Deinagkistrodon acutus
Tatsuno, I.; Isaka, M.; Minami, M.; Hasegawa, T.
NADase as a target molecule of in vivo suppression of the toxicity in the invasive M-1 group A Streptococcal isolates
BMC Microbiol.
10
144
2010
Streptococcus pyogenes M1 GAS
Riddle, D.J.; Bessen, D.E.; Caparon, M.G.
Variation in Streptococcus pyogenes NAD+ glycohydrolase is associated with tissue tropism
J. Bacteriol.
192
3735-3746
2010
Streptococcus pyogenes
Liu, Q.; Graeff, R.; Kriksunov, I.A.; Jiang, H.; Zhang, B.; Oppenheimer, N.; Lin, H.; Potter, B.V.; Lee, H.C.; Hao, Q.
Structural basis for enzymatic evolution from a dedicated ADP-ribosyl cyclase to a multifunctional NAD hydrolase
J. Biol. Chem.
284
27637-27645
2009
Aplysia californica, Homo sapiens (P28907), Homo sapiens
Ghosh, J.; Anderson, P.J.; Chandrasekaran, S.; Caparon, M.G.
Characterization of Streptococcus pyogenes beta-NAD+ glycohydrolase: re-evaluation of enzymatic properties associated with pathogenesis
J. Biol. Chem.
285
5683-5694
2010
Streptococcus pyogenes
Xu, X.; Zhang, L.; Luo, Z.; Shen, D.; Wu, H.; Peng, L.; Song, J.; Zhang, Y.
Metal ions binding to NAD-glycohydrolase from the venom of Agkistrodon acutus: Regulation of multicatalytic activity
Metallomics
2
480-489
2010
Deinagkistrodon acutus
Kuhn, I.; Kellenberger, E.; Said-Hassane, F.; Villa, P.; Rognan, D.; Lobstein, A.; Haiech, J.; Hibert, M.; Schuber, F.; Muller-Steffner, H.
Identification by high-throughput screening of inhibitors of Schistosoma mansoni NAD(+) catabolizing enzyme
Bioorg. Med. Chem.
18
7900-7910
2010
Schistosoma mansoni
Smith, C.L.; Ghosh, J.; Elam, J.S.; Pinkner, J.S.; Hultgren, S.J.; Caparon, M.G.; Ellenberger, T.
Structural basis of Streptococcus pyogenes immunity to its NAD+ glycohydrolase toxin
Structure
19
192-202
2011
Streptococcus pyogenes
Kuhn, I.; Kellenberger, E.; Schuber, F.; Muller-Steffner, H.
Schistosoma mansoni NAD+ catabolizing enzyme: identification of key residues in catalysis
Biochim. Biophys. Acta
1834
2520-2527
2013
Schistosoma mansoni (Q32TF5), Schistosoma mansoni
Chandrasekaran, S.; Ghosh, J.; Port, G.C.; Koh, E.I.; Caparon, M.G.
Analysis of polymorphic residues reveals distinct enzymatic and cytotoxic activities of the Streptococcus pyogenes NAD+ glycohydrolase
J. Biol. Chem.
288
20064-20075
2013
Streptococcus pyogenes, Streptococcus pyogenes JRS4
Nam, T.S.; Park, K.H.; Shawl, A.I.; Kim, B.J.; Han, M.K.; Kim, Y.; Moss, J.; Kim, U.H.
Critical role for NAD glycohydrolase in regulation of erythropoiesis by hematopoietic stem cells through control of intracellular NAD content
J. Biol. Chem.
289
16362-16373
2014
Oryctolagus cuniculus, Oryctolagus cuniculus New Zealand White
Yoon, J.Y.; An, D.R.; Yoon, H.J.; Kim, H.S.; Lee, S.J.; Im, H.N.; Jang, J.Y.; Suh, S.W.
High-resolution crystal structure of Streptococcus pyogenes beta-NAD+ glycohydrolase in complex with its endogenous inhibitor IFS reveals a highly water-rich interface
J. Synchrotron Radiat.
20
962-967
2013
Streptococcus pyogenes serotype M3 (A0A0H2UTN5)
O'Seaghdha, M.; Wessels, M.R.
Streptolysin O and its co-toxin NAD-glycohydrolase protect group A Streptococcus from xenophagic killing
PLoS Pathog.
9
e1003394
2013
Streptococcus pyogenes
Varol, B.; Co?kun, O.e.; Karabulut, S.; Serin, K.R.; Aso?lu, O.; Albeniz, I.; Ta?, F.; Nurten, R.
Clinical significance of serum ADP-ribosylation and NAD glycohydrolase activity in patients with colorectal cancer
Tumor Biol.
35
5575-5582
2014
Homo sapiens
Zhu, L.; Olsen, R.J.; Lee, J.D.; Porter, A.R.; DeLeo, F.R.; Musser, J.M.
Contribution of secreted NADase and streptolysin O to the pathogenesis of epidemic serotype M1 Streptococcus pyogenes infections
Am. J. Pathol.
187
605-613
2017
Streptococcus pyogenes serotype M1 (Q7DAN2)
Hasegawa, T.; Matsumoto, M.; Hata, N.; Yano, H.; Isaka, M.; Tatsuno, I.
Homologous role of CovRS two-component regulatory system in NAD+ -glycohydrolase activity in Streptococcus dysgalactiae subsp. equisimilis as in Streptococcus pyogenes
APMIS
127
87-92
2019
Streptococcus dysgalactiae subsp. equisimilis
Talluri, E.; Pancotto, L.; Ruggiero, P.; Scarselli, M.; Balducci, E.
CagL from Helicobacter pylori has ADP-ribosylation activity and exerts partial protective efficacy in mice
Arch. Biochem. Biophys.
635
102-109
2017
Helicobacter pylori, Helicobacter pylori Shi470
Whitney, J.C.; Quentin, D.; Sawai, S.; LeRoux, M.; Harding, B.N.; Ledvina, H.E.; Tran, B.Q.; Robinson, H.; Goo, Y.A.; Goodlett, D.R.; Raunser, S.; Mougous, J.D.
An interbacterial NAD(P)(+) glycohydrolase toxin requires elongation factor Tu for delivery to target cells
Cell
163
607-619
2015
Pseudomonas aeruginosa (Q9I739), Pseudomonas aeruginosa DSM 22644 (Q9I739)
Chandrasekaran, S.; Caparon, M.G.
The Streptococcus pyogenes NAD(+) glycohydrolase modulates epithelial cell PARylation and HMGB1 release
Cell. Microbiol.
17
1376-1390
2015
Streptococcus pyogenes, Streptococcus pyogenes JRS4
Hsieh, C.; Huang, H.; Hsieh, S.; Zheng, P.; Lin, Y.; Chiang-Ni, C.; Tsai, P.; Wang, S.; Liu, C.; Wu, J.
NAD-glycohydrolase depletes intracellular NAD+ and inhibits acidification of autophagosomes to enhance multiplication of group A Streptococcus in endothelial cells
Front. Microbiol.
9
1733
2018
Streptococcus pyogenes serotype M49 (A0A0H3BX68), Streptococcus pyogenes serotype M1 (Q7DAN2), Streptococcus pyogenes serotype M49 NZ131 (A0A0H3BX68)
Tang, J.Y.; Bullen, N.P.; Ahmad, S.; Whitney, J.C.
Diverse NADase effector families mediate interbacterial antagonism via the type VI secretion system
J. Biol. Chem.
293
1504-1514
2018
Pseudomonas protegens (Q4K3B6), Pseudomonas protegens ATCC BAA-477 (Q4K3B6)
Chandrasekaran, S.; Caparon, M.
The NADase-negative variant of the Streptococcus pyogenes toxin NAD+ glycohydrolase induces JNK1-mediated programmed cellular necrosis
mBio
7
e02215
2016
Streptococcus pyogenes, Streptococcus pyogenes JRS4
Velarde, J.; O'Seaghdha, M.; Baddal, B.; Bastiat-Sempe, B.; Wessels, M.
Binding of NAD+-glycohydrolase to streptolysin O stabilizes both toxins and promotes virulence of group A Streptococcus
mBio
8
e01382
2017
Streptococcus pyogenes serotype M1 (Q7DAN2)
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