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Literature summary for 3.2.2.5 extracted from

  • Bortell, R.; Moss, J.; McKenna, R.C.; Rigby, M.R.; Niedzwiecki, D.; Stevens, L.A.; Patton, W.A.; Mordes, J.P.; Greiner, D.L.; Rossini, A.A.
    Nicotinamide adenine dinucleotide (NAD) and its metabolites inhibit T lymphocyte proliferation: role of cell surface NAD glycohydrolase and pyrophosphatase activities (2001), J. Immunol., 167, 2049-2059.
    View publication on PubMed
Search for more literature for 3.2.2.5

Inhibitors

Inhibitors Comment Organism Structure
additional information phosphatidylinositol-specific phospholipase C removes the GPI-anchored enzyme from the T-cell surface, not the non-GPI-anchored activity like with ART2- T-cells Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane cell surface protein Rattus norvegicus 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus enzyme is involved in regulation of mitogen-stimulated T-cell proliferation by inhibition via NAD+ and ADP-ribose, not nicotinamide ?
-
 ?
NAD+ + H2O Rattus norvegicus
-
 ADP-ribose + nicotinamide
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 6-weeks-old BBDR rats
-

Source Tissue

Source Tissue Comment Organism Textmining
T-cell enzyme is partially GPI-anchored, T-cell lacking ADP-ribosyltransferase activity Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
 Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information enzyme is involved in regulation of mitogen-stimulated T-cell proliferation by inhibition via NAD+ and ADP-ribose, not nicotinamide Rattus norvegicus ?
-
 ?
NAD+ + H2O
-
 Rattus norvegicus ADP-ribose + nicotinamide
-
 ?

Synonyms

Synonyms Comment Organism
NAD glycohydrolase
-
 Rattus norvegicus
NADase
-
 Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
 assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
 assay at Rattus norvegicus