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Literature summary for 3.2.2.5 extracted from

  • Tatsuno, I.; Isaka, M.; Minami, M.; Hasegawa, T.
    NADase as a target molecule of in vivo suppression of the toxicity in the invasive M-1 group A Streptococcal isolates (2010), BMC Microbiol., 10, 144.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.2.2.5

Cloned(Commentary)

Cloned (Comment) Organism
gene nga, cloning n Escherichia coli strain JM109, expression of wild-type and mutant enzymes Streptococcus pyogenes M1 GAS

Protein Variants

Protein Variants Comment Organism
additional information the nga mutant of strain GT01 has lost all virulence Streptococcus pyogenes M1 GAS

Inhibitors

Inhibitors Comment Organism Structure
protein IFS an endogenous NADase inhibitor, encoded by gene ifs, and localized in the cytoplasm. The NADase precursor exists as an inactive complex with IFS Streptococcus pyogenes M1 GAS

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular the enzyme is secreted Streptococcus pyogenes M1 GAS
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Organism

Organism UniProt Comment Textmining
Streptococcus pyogenes M1 GAS
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 diverse strains, e.g. strain SF370, of low and high NADase activity, as isolates taken from streptococcal toxic shock-like syndrome, STSS, patients, gene nga
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Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
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 virulence/Mortality to mice of GAS isolates with different NADase activity, overview Streptococcus pyogenes M1 GAS

Synonyms

Synonyms Comment Organism
NAD-glycohydrolase
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 Streptococcus pyogenes M1 GAS
NADase
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 Streptococcus pyogenes M1 GAS

General Information

General Information Comment Organism
physiological function NADase is important for the virulence of Streptococcus pyogenes in vivo, is important in severe invasive diseases, and is the potential target to suppress the virulence Streptococcus pyogenes M1 GAS