Literature summary for 3.2.2.5 extracted from

Rah, S.Y.; Park, K.H.; Nam, T.S.; Kim, S.J.; Kim, H.; Im, M.J.; Kim, U.H.
Association of CD38 with nonmuscle myosin heavy chain IIA and Lck is essential for the internalization and activation of CD38 (2007), J. Biol. Chem., 282, 5653-5660.

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Application

Application	Comment	Organism
medicine	treatment of lymphokine-activated killer cells with interleukin IL-8 results in internalization of CD38, which co-localizes with nonmuscle myosin heavy chain IIA and tyrosine kinase Lck. Blebbistatin blocks the internalization	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
expression in Escherichia coli, FLAG-tag	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	isoform CD38	-

Subunits

Subunits	Comment	Organism
More	upon stimulation with interleukin IL-8, CD38 associates with nonmuscle myosin heavy chain IIA. Association is dependent on protein kinase G-mediated phosphorylation of nonmuscle myosin heavy chain IIA and occurs through tyrosine kinase Lck	Homo sapiens

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Release 2023.1 (January 2023)