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Literature summary for 3.2.2.5 extracted from
- Properties of NAD-glycohydrolase purified from five-pace snake (Agkistrodon acutus) venom (1988), Toxicon, 26, 535-542.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| EDTA | - |
Deinagkistrodon acutus |  |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.13 | - |
NADP+ | - |
Deinagkistrodon acutus | |
| 0.16 | - |
beta-nicotinamide guanine dinucleotide | - |
Deinagkistrodon acutus | |
| 0.5 | - |
NAD+ | - |
Deinagkistrodon acutus | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Cu2+ | - |
Deinagkistrodon acutus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 50000 | - |
2 * 50000, alpha2, SDS-PAGE | Deinagkistrodon acutus |
| 98000 | - |
gel filtration | Deinagkistrodon acutus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| NAD+ + H2O | Deinagkistrodon acutus | - |
ADPribose + nicotinamide | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Deinagkistrodon acutus | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| glycoprotein | 33% carbohydrate | Deinagkistrodon acutus |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Deinagkistrodon acutus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| venom | - |
Deinagkistrodon acutus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 10.9 | - |
- |
Deinagkistrodon acutus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| beta-nicotine guanine dinucleotide + H2O | - |
Deinagkistrodon acutus | ? | - |
? | |
| NAD+ + H2O | - |
Deinagkistrodon acutus | ADPribose + nicotinamide | - |
? | |
| NADP+ + H2O | - |
Deinagkistrodon acutus | phospho-ADPribose + nicotinamide | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | 2 * 50000, alpha2, SDS-PAGE | Deinagkistrodon acutus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 40 | - |
- |
Deinagkistrodon acutus |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 75 | - |
30 min, half of activity lost | Deinagkistrodon acutus |
| 80 | - |
1-2 min, complete inactivation | Deinagkistrodon acutus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | 8 | - |
Deinagkistrodon acutus |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 2.8 | 9.2 | - |
Deinagkistrodon acutus |
pH Stability
| pH Stability | pH Stability Maximum | Comment | Organism |
|---|---|---|---|
| 8.5 | - |
apruptly dropping of activity above | Deinagkistrodon acutus |
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