Reference on EC 3.2.1.35 - hyaluronoglucosaminidase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Hayashi, S.
Study on the degradation of glycosaminoglycans by canine liver lysosomal enzymes. II. The contributions of hyaluronidase, beta-glucuronidase, sulfatase, and beta-N-acetylhexosaminidase in the case of chondroitin 4-sulfate
J. Biochem.
83
149-157
1978
Canis lupus familiaris
Toida, T.; Ogita, Y.; Suzuki, A.; Toyoda, H.; Imanari, T.
Inhibition of hyaluronidase by fully O-sulfonated glycosaminoglycans
Arch. Biochem. Biophys.
370
176-182
1999
Homo sapiens
Krishnapillai, A.M.; Taylor, K.D.A.; Morris, A.E.J.; Quantick, P.C.
Characterisation of Norway lobster (Nephrops norvegicus) hyaluronidase and comparison with sheep and bovine testicular hyaluronidase
Food Chem.
65
515-521
1999
Nephrops norvegicus
-
Maingonnat, C.; Victor, R.; Bertrand, P.; Courel, M.N.; Maunoury, R.; Delpech, B.
Activation and inhibition of human cancer cell hyaluronidase by proteins
Anal. Biochem.
268
30-34
1998
Homo sapiens
Schwartz, D.M.; Shuster, S.; Jumper, M.D.; Chang, A.; Stern, R.
Human vitreous hyaluronidase: isolation and characterization
Curr. Eye Res.
15
1156-1162
1996
Homo sapiens
Thaler, C.D.; Cardullo, R.A.
Biochemical characterization of a glycosylphosphatidyl-inositol-linked hyaluronidase on mouse sperm
Biochemistry
34
7788-7795
1995
Mus musculus
Long-Rowe, K.O.; Burnett, J.W.
Characteristics of hyaluronidase and hemolytic activity in fishing tentacle nematocyst venom of Chrysaora quinquecirrha
Toxicon
32
165-174
1994
Chrysaora quinquecirrha
Takagaki, K.; Nakamura, T.; Izumi, J.; Saitoh, H.; Endo, M.
Characterization of hydrolysis and transglycosylation by testicular-hyaluronidase using ion-spray mass spectrometry
Biochemistry
33
6503-6507
1994
Bos taurus
Afify, A.M.; Stern, M.; Guntenhöner, M.; Stern, R.
Purification and characterization of human serum hyaluronidase
Arch. Biochem. Biophys.
305
434-441
1993
Homo sapiens
Poh, C.H.; Yuen, R.; Chung, M.C.M.; Khoo, H.E.
Purification and partial characterization of hyaluronidase from stonefish (Synanceja horrida) venom
Comp. Biochem. Physiol. B
101
159-163
1992
Synanceia horrida
Sting, R.; Schaufuss, P.; Blobel, H.
Isolation and characterization of hyaluronidases from Streptococcus dysgalactiae, S. zooepidemicus and S. equi
Zentralbl. Bakteriol.
272
276-282
1990
Streptococcus dysgalactiae
Ramanaiah, M.; Parthasarathy, P.R.; Venkaiah, B.
Isolation end characterization of hyaluronidase from scorpion (Heterometrus fulvipes) venom
Biochem. Int.
20
301-310
1990
Chersonesometrus fulvipes
Anand, S.R.; Kaur, S.P.; Chaudhry, P.S.
Distribution of beta-N-acetylglucosaminidase, hyaluronoglucosaminidase and acrosin in buffalo and goat spermatozao
Hoppe-Seyler's Z. Physiol. Chem.
358
685-688
1977
Bubalus sp., Capra hircus
Morton, D.B.
Purification and properties of ovine testicular hyaluronidase
Biochem. Soc. Trans.
1
385
1973
Ovis aries aries
-
Weissmann, B.
The transglycosylative action of testicular hyaluronidase
J. Biol. Chem.
216
783-794
1955
Bos taurus
Meyer, K.; Rapport, M.M.
Hyaluronidases
Adv. Enzymol. Relat. Subj. Biochem.
13
199-236
1952
Bos taurus, Cavia porcellus, Homo sapiens, Ovis aries aries, Sus scrofa
Asteriou, T.; Deschrevel, B.; Delpech, B.; Bertrand, P.; Bultelle, F.; Merai, C.; Vincent, J.C.
An improved assay for the N-Acetyl-D-glucosamine reducing ends of polysaccharides in the presence of proteins
Anal. Biochem.
293
53-59
2001
Bos taurus
Ikegami-Kawai, M.; Takahashi, T.
Microanalysis of hyaluronan oligosaccharides by polyacrylamide gel electrophoresis and its application to assay of hyaluronidase activity
Anal. Biochem.
311
157-165
2002
Bos taurus
Takahashi, T.; Ikegami-Kawai, M.; Okuda, R.; Suzuki, K.
A fluorometric Morgan-Elson method for hyaluronidase activity
Anal. Biochem.
322
257-263
2003
Bos taurus, Oryctolagus cuniculus, Homo sapiens
Kudo, K.; Tu, A.T.
Characterization of hyaluronidase isolated from Agkistrodon contortrix contortrix (Southern Copperhead) venom
Arch. Biochem. Biophys.
386
154-162
2001
Agkistrodon contortrix contortrix
Comtesse, N.; Maldener, E.; Meese, E.
Identification of a nuclear variant of MGEA5, a cytoplasmic hyaluronidase and a beta-N-acetylglucosaminidase
Biochem. Biophys. Res. Commun.
283
634-640
2001
Homo sapiens (O60502), Homo sapiens
Nakatani, H.
Monte Carlo simulation of hyaluronidase reaction involving hydrolysis, transglycosylation and condensation
Biochem. J.
365
701-705
2002
Bos taurus
Maksimenko, A.V.; Schechilina, Y.V.; Tischenko, E.G.
Role of glycosaminoglycan microenvironment of hyaluronidase in regulation of its endoglycosidase activity
Biochemistry (Moscow)
68
1055-1062
2003
Bos taurus
-
Ling, S.K.; Tanaka, T.; Kouno, I.
Effects of iridoids on lipoxygenase and hyaluronidase activities and their activation by beta-glucosidase in the presence of amino acids
Biol. Pharm. Bull.
26
352-356
2003
Bos taurus
Maingonnat, C.; Courel, M.N.; Bertrand, P.; Vincent, J.C.; Sesboue, R.; Delpech, B.
Hyaluronidase in sera of tumour-bearing nude mice
Biomarkers
8
333-338
2003
Mus musculus
Maksimenko, A.V.; Petrova, M.L.; Tischenko, E.G.; Schechilina, Y.V.
Chemical modification of hyaluronidase regulates its inhibition by heparin
Eur. J. Pharm. Biopharm.
51
33-38
2001
Bos taurus
Reitinger, S.; Müllegger, J.; Lepperdinger, G.
Xenopus kidney hyaluronidase-1 (XKH1), a novel type of membrane-bound hyaluronidase, solely degrades hyaluronan at neutral pH
FEBS Lett.
505
213-216
2001
Xenopus laevis (Q8UVT7), Xenopus laevis
Rahmanian, M.; Heldin, P.
Testicular hyaluronidase induces tubular structures of endothelial cells grown in three-dimensional collagen gel through a CD44-mediated mechanism
Int. J. Cancer
97
601-607
2002
Mus musculus
Li, M.W; Yudin, A.I.; Robertson, K.R.; Cherr, G.N.; Overstreet, J.W.
Importance of glycosylation and disulfide bonds in hyaluronidase activity of macaque sperm surface PH-20
J. Androl.
23
211-219
2002
Macaca sp.
Lokeshwar, V.B.; Schroeder, G.L.; Carey, R.I.; Soloway, M.S.; Iida, N.
Regulation of hyaluronidase activity by alternative mRNA splicing
J. Biol. Chem.
277
33654-33663
2002
Homo sapiens, Homo sapiens (O43820), Homo sapiens (Q12794)
Okorukwu, O.; Vercruysse, K.P.
Effects of ascorbic acid and analogs on the activity of testicular hyaluronidase and hyaluronan lyase on hyaluronan
J. Enzyme Inhib. Med. Chem.
18
377-382
2003
Bos taurus
Girish, K.S.; Jagadeesha, D.K.; Rajeev, K.B.; Kemparaju, K.
Snake venom hyaluronidase: an evidence for isoforms and extracellular matrix degradation
Mol. Cell. Biochem.
240
105-110
2002
Gloydius blomhoffii, Bothrops asper, Crotalus atrox, Echis carinatus, Naja melanoleuca, Naja naja, Daboia russelii, Protobothrops flavoviridis, Protobothrops mucrosquamatus, Naja kaouthia, Naja sputatrix, Vipera elegans, Echis pyramidum leakeyi, Echis carinatus sochureki, Protobothrops elegans
Markovic-Housley, Z.; Miglierini, G.; Soldatova, L.; Rizkallah, P.J.; Muller, U.; Schirmer, T.
Crystal structure of hyaluronidase, a major allergen of bee venom
Structure
8
1025-1035
2000
Apis mellifera (Q08169)
Girish, K.S.; Kemparaju, K.
A low molecular weight isoform of hyaluronidase: purification from Indian cobra (Naja naja) venom and partial characterization
Biochemistry (Moscow)
70
708-712
2005
Naja naja
Girish, K.S.; Kemparaju, K.
Inhibition of Naja naja venom hyaluronidase by plant-derived bioactive components and polysaccharides
Biochemistry (Moscow)
70
948-952
2005
Naja naja
Girish, K.S.; Shashidharamurthy, R.; Nagaraju, S.; Gowda, T.V.; Kemparaju, K.
Isolation and characterization of hyaluronidase a "spreading factor" from Indian cobra (Naja naja) venom
Biochimie
86
193-202
2004
Naja naja
Chowpongpang, S.; Shin, H.S.; Kim, E.K.
Cloning and characterization of the bovine testicular PH-20 hyaluronidase core domain
Biotechnol. Lett.
26
1247-1252
2004
Bos taurus (Q7YS45), Bos taurus
Stern, R.; Jedrzejas, M.J.
Hyaluronidases: their genomics, structures, and mechanisms of action
Chem. Rev.
106
818-839
2006
Bos taurus, Homo sapiens, Mus musculus, Apis mellifera (Q08169)
Gatphayak, K.; Knorr, C.; Beck, J.; Brenig, B.
Molecular characterization of porcine hyaluronidase genes 1, 2, and 3 clustered on SSC13q21
Cytogenet. Genome Res.
109
535
2005
Sus scrofa (Q6RHW2), Sus scrofa (Q6RHW3), Sus scrofa (Q6RHW4)
-
Ng, H.C.; Ranganathan, S.; Chua, K.L.; Khoo, H.E.
Cloning and molecular characterization of the first aquatic hyaluronidase, SFHYA1, from the venom of stonefish (Synanceja horrida)
Gene
346
71-81
2005
Synanceia horrida (Q801Z8), Synanceia horrida
Vigdorovich, V.; Strong, R.K.; Miller, A.D.
Expression and characterization of a soluble, active form of the jaagsiekte sheep retrovirus receptor, Hyal2
J. Virol.
79
79-86
2005
jaagsiekte sheep retrovirus
Salmen, S.; Hoechstetter, J.; Kaesbauer, C.; Paper, D.H.; Bernhardt, G.; Buschauer, A.
Sulphated oligosaccharides as inhibitors of hyaluronidases from bovine testis, bee venom and Streptococcus agalactiae
Planta Med.
71
727-732
2005
Apis mellifera, Bos taurus
Morey, S.S.; Kiran, K.M.; Gadag, J.R.
Purification and properties of hyaluronidase from Palamneus gravimanus (Indian black scorpion) venom
Toxicon
47
188-195
2006
Palamneus gravimanus
Matalon, R.; Surendran, S.; Campbell, G.A.; Michals-Matalon, K.; Tyring, S.K.; Grady, J.; Cheng, S.; Kaye, E.
Hyaluronidase increases the biodistribution of acid alpha-1,4 glucosidase in the muscle of Pompe disease mice: an approach to enhance the efficacy of enzyme replacement therapy
Biochem. Biophys. Res. Commun.
350
783-787
2006
Bos taurus
Chao, K.L.; Muthukumar, L.; Herzberg, O.
Structure of human hyaluronidase-1, a hyaluronan hydrolyzing enzyme involved in tumor growth and angiogenesis
Biochemistry
46
6911-6920
2007
Homo sapiens (Q12794), Homo sapiens
Christopoulos, T.A.; Papageorgakopoulou, N.; Theocharis, D.A.; Mastronikolis, N.S.; Papadas, T.A.; Vynios, D.H.
Hyaluronidase and CD44 hyaluronan receptor expression in squamous cell laryngeal carcinoma
Biochim. Biophys. Acta
1760
1039-1045
2006
Homo sapiens
Spickenreither, M.; Braun, S.; Bernhardt, G.; Dove, S.; Buschauer, A.
Novel 6-O-acylated vitamin C derivatives as hyaluronidase inhibitors with selectivity for bacterial lyases
Bioorg. Med. Chem. Lett.
16
5313-5316
2006
Bos taurus
Lokeshwar, V.B.; Estrella, V.; Lopez, L.; Kramer, M.; Gomez, P.; Soloway, M.S.; Lokeshwar, B.L.
HYAL1-v1, an alternatively spliced variant of HYAL1 hyaluronidase: a negative regulator of bladder cancer
Cancer Res.
66
11219-11227
2006
Homo sapiens (Q12794)
Kobayashi, S.; Ohmae, M.; Ochiai, H.; Fujikawa, S.
A hyaluronidase supercatalyst for the enzymatic polymerization to synthesize glycosaminoglycans
Chemistry
12
5962-5971
2006
Bos taurus, Ovis aries
Hofinger, E.S.; Spickenreither, M.; Oschmann, J.; Bernhardt, G.; Rudolph, R.; Buschauer, A.
Recombinant human hyaluronidase Hyal-1: insect cells versus Escherichia coli as expression system and identification of low molecular weight inhibitors
Glycobiology
17
444-453
2007
Homo sapiens
Hemming, R.; Martin, D.C.; Slominski, E.; Nagy, J.I.; Halayko, A.J.; Pind, S.; Triggs-Raine, B.
Mouse Hyal3 encodes a 45-56 kDa glycoprotein whose overexpression increases hyaluronidase 1 activity in cultured cells
Glycobiology
18
280-289
2008
Mus musculus (Q8VEI3), Mus musculus
Hosoe, T.; Sakai, H.; Ichikawa, M.; Itabashi, T.; Ishizaki, T.; Kawai, K.
Lepidepyrone, a new gamma-pyrone derivative, from Neolentinus lepideus, inhibits hyaluronidase
J. Antibiot.
60
388-390
2007
Bos taurus
Vigdorovich, V.; Miller, A.D.; Strong, R.K.
Ability of hyaluronidase 2 to degrade extracellular hyaluronan is not required for its function as a receptor for Jaagsiekte sheep retrovirus
J. Virol.
81
3124-3129
2007
Homo sapiens
Asteriou, T.; Vincent, J.; Tranchepain, F.; Deschrevel, B.
Inhibition of hyaluronan hydrolysis catalyzed by hyaluronidase at high substrate concentration and low ionic strength
Matrix Biol.
25
166-174
2006
Bos taurus
Deschrevel, B.; Lenormand, H.; Tranchepain, F.; Levasseur, N.; Asteriou, T.; Vincent, J.C.
Hyaluronidase activity is modulated by complexing with various polyelectrolytes including hyaluronan
Matrix Biol.
27
242-253
2008
Bos taurus
Reitinger, S.; Boroviak, T.; Laschober, G.T.; Fehrer, C.; Muellegger, J.; Lindner, H.; Lepperdinger, G.
High-yield recombinant expression of the extremophile enzyme, bee hyaluronidase in Pichia pastoris
Protein Expr. Purif.
57
226-233
2008
synthetic construct (EU152302), Apis mellifera (Q08169)
Cibulkova, E.; Manaskova, P.; Jonakova, V.; Ticha, M.
Preliminary characterization of multiple hyaluronidase forms in boar reproductive tract
Theriogenology
68
1047-1054
2007
Sus scrofa
da Silveira, R.B.; Chaim, O.M.; Mangili, O.C.; Gremski, W.; Dietrich, C.P.; Nader, H.B.; Veiga, S.S.
Hyaluronidases in Loxosceles intermedia (Brown spider) venom are endo-beta-N-acetyl-D-hexosaminidases hydrolases
Toxicon
49
758-768
2007
Loxosceles intermedia
Nagaraju, S.; Devaraja, S.; Kemparaju, K.
Purification and properties of hyaluronidase from Hippasa partita (funnel web spider) venom gland extract
Toxicon
50
383-393
2007
Hippasa partita
Monzon, M.E.; Manzanares, D.; Schmid, N.; Casalino-Matsuda, S.M.; Forteza, R.M.
Hyaluronidase expression and activity is regulated by pro-inflammatory cytokines in human airway epithelial cells
Am. J. Respir. Cell Mol. Biol.
39
289-295
2008
Homo sapiens (O43820), Homo sapiens (Q12794), Homo sapiens (Q12891), Homo sapiens
Ganesh, S.; Gonzalez-Edick, M.; Gibbons, D.; Van Roey, M.; Jooss, K.
Intratumoral coadministration of hyaluronidase enzyme and oncolytic adenoviruses enhances virus potency in metastatic tumor models
Clin. Cancer Res.
14
3933-3941
2008
Homo sapiens
Kaneiwa, T.; Yamada, S.; Mizumoto, S.; Montano, A.M.; Mitani, S.; Sugahara, K.
Identification of a novel chondroitin hydrolase in Caenorhabditis elegans
J. Biol. Chem.
283
14971-14979
2008
Caenorhabditis elegans, Caenorhabditis elegans N2
Zhang, L.; Bharadwaj, A.G.; Casper, A.; Barkley, J.; Barycki, J.J.; Simpson, M.A.
Hyaluronidase activity of human hyal1 requires active site acidic and tyrosine residues
J. Biol. Chem.
284
9433-9442
2009
Homo sapiens, Homo sapiens (Q12794)
Wang, F.; Grigorieva, E.V.; Li, J.; Senchenko, V.N.; Pavlova, T.V.; Anedchenko, E.A.; Kudryavtseva, A.V.; Tsimanis, A.; Angeloni, D.; Lerman, M.I.; Kashuba, V.I.; Klein, G.; Zabarovsky, E.R.
HYAL1 and HYAL2 inhibit tumour growth in vivo but not in vitro
PLoS ONE
3
e3031
2008
Homo sapiens (Q12794), Homo sapiens (Q12891), Homo sapiens
Zhang, L.S.; Mummert, M.E.
Development of a fluorescent substrate to measure hyaluronidase activity
Anal. Biochem.
379
80-85
2008
Bos taurus
Feng, L.; Gao, R.; Gopalakrishnakone, P.
Isolation and characterization of a hyaluronidase from the venom of Chinese red scorpion Buthus martensi
Comp. Biochem. Physiol. C
148
250-257
2008
Mesobuthus martensii (P86100), Mesobuthus martensii
Kramer, M.W.; Golshani, R.; Merseburger, A.S.; Knapp, J.; Garcia, A.; Hennenlotter, J.; Duncan, R.C.; Soloway, M.S.; Jorda, M.; Kuczyk, M.A.; Stenzl, A.; Lokeshwar, V.B.
HYAL-1 Hyaluronidase: A Potential Prognostic Indicator for Progression to Muscle Invasion and Recurrence in Bladder Cancer
Eur. Urol.
57
86-93
2010
Homo sapiens (Q12794), Homo sapiens
Chen, F.; Kakizaki, I.; Yamaguchi, M.; Kojima, K.; Takagaki, K.; Endo, M.
Novel products in hyaluronan digested by bovine testicular hyaluronidase
Glycoconj. J.
26
559-566
2008
Bos taurus
Sharma, R.; Mahadeswaraswamy, Y.H.; Harish Kumar, K.; Devaraja, S.; Kemparaju, K.; Vishwanath, B.S.; Girish, K.S.
Effect of anticoagulants on the plasma hyaluronidase activities
J. Clin. Lab. Anal.
23
29-33
2009
Homo sapiens (Q12794)
Kaessler, A.; Nourrisson, M.R.; Duflos, M.; Jose, J.
Indole carboxamides inhibit bovine testes hyaluronidase at pH 7.0 and indole acetamides activate the enzyme at pH 3.5 by different mechanisms
J. Enzyme Inhib. Med. Chem.
23
719-727
2008
Bos taurus
Bralley, E.; Greenspan, P.; Hargrove, J.L.; Hartle, D.K.
Inhibition of hyaluronidase activity by select sorghum brans
J. Med. Food
11
307-312
2008
Bos taurus
Deschrevel, B.; Tranchepain, F.; Vincent, J.C.
Chain-length dependence of the kinetics of the hyaluronan hydrolysis catalyzed by bovine testicular hyaluronidase
Matrix Biol.
27
475-486
2008
Bos taurus
Volfova, V.; Hostomska, J.; Cerny, M.; Votypka, J.; Volf, P.
Hyaluronidase of bloodsucking insects and its enhancing effect on leishmania infection in mice
PLoS Negl. Trop. Dis.
2
e294
2008
Bos taurus, Chrysops viduatus, Ctenocephalides felis, Culex quinquefasciatus, Culicoides kibunensis, Eusimulium latipes, Phlebotomus papatasi, Simulium ornatum
Stern, R.
Hyaluronidases in cancer biology
Semin. Cancer Biol.
18
275-280
2008
Homo sapiens
Magalhaes, M.R.; da Silva, N.J.; Ulhoa, C.J.
A hyaluronidase from Potamotrygon motoro (freshwater stingrays) venom: isolation and characterization
Toxicon
51
1060-1067
2008
Potamotrygon motoro
de la Motte, C.; Nigro, J.; Vasanji, A.; Rho, H.; Kessler, S.; Bandyopadhyay, S.; Danese, S.; Fiocchi, C.; Stern, R.
Platelet-derived hyaluronidase 2 cleaves hyaluronan into fragments that trigger monocyte-mediated production of proinflammatory cytokines
Am. J. Pathol.
174
2254-2264
2009
Mus musculus (O35632), Homo sapiens (Q12891)
Ormiston, M.L.; Slaughter, G.R.; Deng, Y.; Stewart, D.J.; Courtman, D.W.
The enzymatic degradation of hyaluronan is associated with disease progression in experimental pulmonary hypertension
Am. J. Physiol. Lung Cell Mol. Physiol.
298
L148-L157
2010
Rattus norvegicus (Q76HN1)
Kim, J.W.; Kim, J.H.; Chung, S.J.; Chung, B.H.
An operationally simple colorimetric assay of hyaluronidase activity using cationic gold nanoparticles
Analyst
134
1291-1293
2009
Bos taurus, Homo sapiens
Berdiaki, A.; Nikitovic, D.; Tsatsakis, A.; Katonis, P.; Karamanos, N.K.; Tzanakakis, G.N.
bFGF induces changes in hyaluronan synthase and hyaluronidase isoform expression and modulates the migration capacity of fibrosarcoma cells
Biochim. Biophys. Acta
1790
1258-1265
2009
Homo sapiens (Q12794), Homo sapiens (Q12891)
Kimura, M.; Kim, E.; Kang, W.; Yamashita, M.; Saigo, M.; Yamazaki, T.; Nakanishi, T.; Kashiwabara, S.; Baba, T.
Functional roles of mouse sperm hyaluronidases, HYAL5 and SPAM1, in fertilization
Biol. Reprod.
81
939-947
2009
Mus musculus
Barla, F.; Higashijima, H.; Funai, S.; Sugimoto, K.; Harada, N.; Yamaji, R.; Fujita, T.; Nakano, Y.; Inui, H.
Inhibitive effects of alkyl gallates on hyaluronidase and collagenase
Biosci. Biotechnol. Biochem.
73
2335-2337
2009
Bos taurus
Nykopp, T.; Rilla, K.; Sironen, R.; Tammi, M.; Tammi, R.; Hämäläinen, K.; Heikkinen, A.; Komulainen, M.; Kosma, V.; Anttila, M.
Expression of hyaluronan synthases (HAS1-3) and hyaluronidases (HYAL1-2) in serous ovarian carcinomas: Inverse correlation between HYAL1 and hyaluronan content
BMC Cancer
9
143
2009
Homo sapiens (Q12794), Homo sapiens (Q12891)
Murata, T.; Watahiki, M.; Tanaka, Y.; Miyase, T.; Yoshizaki, F.
Hyaluronidase inhibitors from Takuran, Lycopus lucidus
Chem. Pharm. Bull.
58
394-397
2010
Bos taurus
Wang, X.Y.; Tan, J.X.; Vasse, M.; Delpech, B.; Ren, G.S.
Comparison of hyaluronidase expression, invasiveness and tubule formation promotion in ER (-) and ER (+) breast cancer cell lines in vitro
Chin. Med. Sci.
122
1300-1304
2009
Homo sapiens
Belem-Goncalves, S.; Matar, G.; Tsan, P.; Lafont, D.; Boullanger, P.; Salim, V.M.; Alves, T.L.; Lancelin, J.M.; Besson, F.
Hyaluronidase binds differently DPPC, DPPS or GlcNAc-bearing glycolipid biomimetic monolayers
Colloids Surf. B Biointerfaces
75
466-471
2010
Bos taurus
Narayanan, R.; Kuppermann, B.D.
Hyaluronidase for pharmacologic vitreolysis
Dev. Ophthalmol.
44
20-25
2009
Ovis aries
Colombo, R.
Editorial Comment on: HYAL-1 hyaluronidase: A potential prognostic indicator for progression to muscle invasion and recurrence in bladder cancer
Eur. Urol.
57
93-94
2010
Homo sapiens (Q12794)
Reitinger, S.; Muellegger, J.; Greiderer, B.; Nielsen, J.E.; Lepperdinger, G.
Designed human serum hyaluronidase 1 variant, HYAL1DeltaL, exhibits activity up to pH 5.9
J. Biol. Chem.
284
19173-19177
2009
Homo sapiens (Q12794), Homo sapiens
Duterme, C.; Mertens-Strijthagen, J.; Tammi, M.; Flamion, B.
Two novel functions of hyaluronidase-2 (Hyal2) are formation of the glycocalyx and control of CD44-ERM interactions
J. Biol. Chem.
284
33495-33508
2009
Rattus norvegicus (Q9Z2Q3)
Iwanaga, A.; Kusano, G.; Warashina, T.; Miyase, T.
Hyaluronidase inhibitors from "Cimicifugae Rhizoma" (a mixture of the rhizomes of Cimicifuga dahurica and C. heracleifolia)
J. Nat. Prod.
73
573-578
2010
Bos taurus
Lenormand, H.; Tranchepain, F.; Deschrevel, B.; Vincent, J.C.
The hyaluronan-protein complexes at low ionic strength: how the hyaluronidase activity is controlled by the bovine serum albumin
Matrix Biol.
28
365-372
2009
Bos taurus
Ruegheimer, L.; Olerud, J.; Johnsson, C.; Takahashi, T.; Shimizu, K.; Hansell, P.
Hyaluronan synthases and hyaluronidases in the kidney during changes in hydration status
Matrix Biol.
28
390-395
2009
Rattus norvegicus, Rattus norvegicus (Q76HM9), Rattus norvegicus (Q76HN1), Rattus norvegicus (Q9Z2Q3)
Evison, M.; Pretty, C.; Taylor, E.; Franklin, C.
Human recombinant hyaluronidase (Cumulase) improves intracytoplasmic sperm injection survival and fertilization rates
Reprod. Biomed. Online
18
811-814
2009
Homo sapiens
Srivastav, A.; Chandra, A.; Singh, M.; Jamal, F.; Rastogi, P.; Rajendran, S.M.; Bansode, F.W.; Lakshmi, V.
Inhibition of hyaluronidase activity of human and rat spermatozoa in vitro and antispermatogenic activity in rats in vivo by Terminalia chebula, a flavonoid rich plant
Reprod. Toxicol.
29
214-224
2010
Homo sapiens, Rattus norvegicus
de Sa, V.; Canavez, F.; Silva, I.; Srougi, M.; Leite, K.
Isoforms of hyaluronidases can be a predictor of a prostate cancer of good prognosis
Urol. Oncol.
27
377-381
2009
Homo sapiens
Kakizaki, I.; Nukatsuka, I.; Takagaki, K.; Majima, M.; Iwafune, M.; Suto, S.; Endo, M.
Effects of divalent cations on bovine testicular hyaluronidase catalyzed transglycosylation of chondroitin sulfates
Biochem. Biophys. Res. Commun.
406
239-244
2011
Bos taurus
Andre, B.; Duterme, C.; Van Moer, K.; Mertens-Strijthagen, J.; Jadot, M.; Flamion, B.
Hyal2 is a glycosylphosphatidylinositol-anchored, lipid raft-associated hyaluronidase
Biochem. Biophys. Res. Commun.
411
175-179
2011
Homo sapiens (Q12891)
Kaessler, A.; Olgen, S.; Jose, J.
Autodisplay of catalytically active human hyaluronidase hPH-20 and testing of enzyme inhibitors
Eur. J. Pharm. Sci.
42
138-147
2011
Bos taurus, Homo sapiens
Kakizaki, I.; Ibori, N.; Kojima, K.; Yamaguchi, M.; Endo, M.
Mechanism for the hydrolysis of hyaluronan oligosaccharides by bovine testicular hyaluronidase
FEBS J.
277
1776-1786
2010
Bos taurus
Bakke, M.; Kamei, J.; Obata, A.
Identification, characterization, and molecular cloning of a novel hyaluronidase, a member of glycosyl hydrolase family 16, from Penicillium spp.
FEBS Lett.
585
115-120
2011
Talaromyces purpureogenus (E7FI87), Talaromyces purpureogenus
Lenormand, H.; Deschrevel, B.; Vincent, J.
pH effects on the hyaluronan hydrolysis catalysed by hyaluronidase in the presence of proteins: Part I. Dual aspect of the pH-dependence
Matrix Biol.
29
330-337
2010
Bos taurus
Chatel, A.; Hemming, R.; Hobert, J.; Natowicz, M.R.; Triggs-Raine, B.; Merz, D.C.
The C. elegans hyaluronidase: a developmentally significant enzyme with chondroitin-degrading activity at both acidic and neutral pH
Matrix Biol.
29
494-502
2010
Caenorhabditis elegans
Reese, K.L.; Aravindan, R.G.; Griffiths, G.S.; Shao, M.; Wang, Y.; Galileo, D.S.; Atmuri, V.; Triggs-Raine, B.L.; Martin-Deleon, P.A.
Acidic hyaluronidase activity is present in mouse sperm and is reduced in the absence of SPAM1: evidence for a role for hyaluronidase 3 in mouse and human sperm
Mol. Reprod. Dev.
77
759-772
2010
Mus musculus
Jung, Y.; Jung, M.Y.; Park, J.H.; Jung, G.C.; Hong, Y.S.; Yeom, C.H.; Lee, S.
Production of human hyaluronidase in a plant-derived protein expression system: plant-based transient production of active human hyaluronidase
Protein Expr. Purif.
74
181-188
2010
Homo sapiens (O43820), Homo sapiens (Q12794), Homo sapiens (Q12891), Homo sapiens (Q2M3T9), Homo sapiens
Madokoro, M.; Ueda, A.; Kiriake, A.; Shiomi, K.
Properties and cDNA cloning of a hyaluronidase from the stonefish Synanceia verrucosa venom
Toxicon
58
285-292
2011
Synanceia verrucosa (E5RWZ0), Synanceia verrucosa
Olgen, S.; Kaessler, A.; Kilic-Kurt, Z.; Jose, J.
Investigation of aminomethyl indole derivatives as hyaluronidase inhibitors
Z. Naturforsch. C
65
445-450
2010
Bos taurus
Liu, M.; Yin, H.; Dong, J.; Xiao, L.; Liu, G.; Qian, Z.; Miao, J.
Inhibition and interaction with hyaluronidase by compounds from hop (Humulus lupulus L) flowers
Asian J. Chem.
25
10262-10266
2013
Bos taurus
-
Bordon, K.C.; Perino, M.G.; Giglio, J.R.; Arantes, E.C.
Isolation, enzymatic characterization and antiedematogenic activity of the first reported rattlesnake hyaluronidase from Crotalus durissus terrificus venom
Biochimie
94
2740-2748
2012
Crotalus durissus terrificus (B3EWP2)
Myose, M.; Warashina, T.; Miyase, T.
Triterpene saponins with hyaluronidase inhibitory activity from the seeds of Camellia sinensis
Chem. Pharm. Bull.
60
612-623
2012
Bos taurus
Wang, Z.; Guo, C.; Xu, Y.; Liu, G.; Lu, C.; Liu, Y.
Two novel functions of hyaluronidase from Streptococcus agalactiae are enhanced intracellular survival and inhibition of proinflammatory cytokine expression
Infect. Immun.
82
2615-2625
2014
Streptococcus agalactiae, Streptococcus agalactiae GD201008-001
Sunitha, K.; Suresh, P.; Santhosh, M.S.; Hemshekhar, M.; Thushara, R.M.; Marathe, G.K.; Thirunavukkarasu, C.; Kemparaju, K.; Kumar, M.S.; Girish, K.S.
Inhibition of hyaluronidase by N-acetyl cysteine and glutathione: role of thiol group in hyaluronan protection
Int. J. Biol. Macromol.
55
39-46
2013
Bos taurus, Echis carinatus, Homo sapiens, Apis mellifera (Q08169)
Goto, Y.; Niwa, Y.; Suzuki, T.; Dohmae, N.; Umezawa, K.; Simizu, S.
C-mannosylation of human hyaluronidase 1: possible roles for secretion and enzymatic activity
Int. J. Oncol.
45
344-350
2014
Homo sapiens
Kaneiwa, T.; Miyazaki, A.; Kogawa, R.; Mizumoto, S.; Sugahara, K.; Yamada, S.
Identification of amino acid residues required for the substrate specificity of human and mouse chondroitin sulfate hydrolase (conventional hyaluronidase-4)
J. Biol. Chem.
287
42119-42128
2012
Homo sapiens, Mus musculus
Li, R.; Yu, Q.; Han, L.; Rong, L.; Yang, M.; An, M.
Isolation and enzymatic characterization of the first reported hyaluronidase from Yak (Bos grunniens) testis
Korean J. Chem. Engin.
31
2027-2034
2014
Bos grunniens
-
Tarannum, S.; Mohamed, R.; Vishwanath, B.
Inhibition of testicular and Vipera russelli snake venom hyaluronidase activity by Butea monosperma (Lam) Kuntze stem bark
Nat. Prod. Res.
26
1708-1711
2012
Ovis aries, Mus musculus, Daboia russelii
Ferrer, V.P.; de Mari, T.L.; Gremski, L.H.; Trevisan Silva, D.; da Silveira, R.B.; Gremski, W.; Chaim, O.M.; Senff-Ribeiro, A.; Nader, H.B.; Veiga, S.S.
A novel hyaluronidase from brown spider (Loxosceles intermedia) venom (Dietrich's Hyaluronidase): from cloning to functional characterization
PLoS Negl. Trop. Dis.
7
e2206
2013
Loxosceles intermedia (R4J7Z9), Loxosceles intermedia
Horta, C.C.; Magalhaes, B.d.e..F.; Oliveira-Mendes, B.B.; do Carmo, A.O.; Duarte, C.G.; Felicori, L.F.; Machado-de-Avila, R.A.; Chavez-Olortegui, C.; Kalapothakis, E.
Molecular, immunological, and biological characterization of Tityus serrulatus venom hyaluronidase: new insights into its role in envenomation
PLoS Negl. Trop. Dis.
8
e2693
2014
Tityus serrulatus (P85841), Tityus serrulatus (W0HFN9)
Jin, P.; Kang, Z.; Zhang, N.; Du, G.; Chen, J.
High-yield novel leech hyaluronidase to expedite the preparation of specific hyaluronan oligomers
Sci. Rep.
4
4471
2014
Bos taurus
Karasova, J.Z.; Pavlik, M.; Chladek, J.; Jun, D.; Kuca, K.
Hyaluronidase: its effects on HI-6 dichloride and dimethanesulphonate pharmacokinetic profile in pigs
Toxicol. Lett.
220
167-171
2013
Bos taurus
Fang, S.; Hays Putnam, A.M.; LaBarre, M.J.
Kinetic investigation of recombinant human hyaluronidase PH20 on hyaluronic acid
Anal. Biochem.
480
74-81
2015
Homo sapiens (P38567), Homo sapiens
Vivas-Ruiz, D.E.; Gonzalez-Kozlova, E.E.; Delgadillo, J.; Palermo, P.M.; Sandoval, G.A.; Lazo, F.; Rodriguez, E.; Chavez-Olortegui, C.; Yarleque, A.; Sanchez, E.F.
Biochemical and molecular characterization of the hyaluronidase from Bothrops atrox Peruvian snake venom
Biochimie
162
33-45
2019
Bothrops atrox (A0A2H4Z8F4), Bothrops atrox
Albeiroti, S.; Ayasoufi, K.; Hill, D.; Shen, B.; De La Motte, C.
Platelet hyaluronidase-2 An enzyme that translocates to the surface upon activation to function in extracellular matrix degradation
Blood
125
1460-1469
2015
Homo sapiens (Q12891), Homo sapiens
Fayad, S.; Ayela, B.; Chat, C.; Morin, P.; Lopin-Bon, C.; Nehme, R.
Effect of modified di- and trisaccharides on hyaluronidase activity assessed by capillary electrophoresis-based enzymatic assay
Carbohydr. Res.
475
56-64
2019
Bos taurus (Q5E985)
Buhren, B.A.; Schrumpf, H.; Hoff, N.P.; Boelke, E.; Hilton, S.; Gerber, P.A.
Hyaluronidase from clinical applications to molecular and cellular mechanisms
Eur. J. Med. Res.
21
5
2016
Bos taurus
Xin, Y.; Hao, M.; Fan, G.; Zhang, Y.; Zheng, M.; Zhang, L.
Affinity adsorption of bovine hyaluronidase with ligands targeting to active site
J. Chromatogr. B Analyt. Technol. Biomed. Life Sci.
1092
422-431
2018
Bos taurus (Q5E985), Bos taurus
Bhavya, J.; Vineetha, M.; Sundaram, P.; Veena, S.; Dhananjaya, B.; More, S.
Low-molecular weight hyaluronidase from the venom of Bungarus caeruleus (Indian common krait) snake isolation and partial characterization
J. Liq. Chromatogr. Relat. Technol.
39
203-208
2016
Bungarus caeruleus
-
Park, C.; Kim, Y.H.; Lee, S.R.; Park, S.; Jung, Y.; Lee, Y.; Kim, J.S.; Eom, T.; Kim, J.S.; Lee, D.M.; Song, B.S.; Sim, B.W.; Kim, S.U.; Chang, K.T.; Kim, E.
Characterization of recombinant bovine sperm hyaluronidase and identification of an important Asn-X-Ser/Thr motif for its activity
J. Microbiol. Biotechnol.
28
1547-1553
2018
Bos taurus (Q2YDK3), Bos taurus
Liu, Y.; Staerk, D.; Nielsen, M.N.; Nyberg, N.; Jaeger, A.K.
High-resolution hyaluronidase inhibition profiling combined with HPLC-HRMS-SPE-NMR for identification of anti-necrosis constituents in Chinese plants used to treat snakebite
Phytochemistry
119
62-69
2015
Deinagkistrodon acutus, Naja atra, Trimeresurus stejnegeri, Gloydius brevicaudus
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