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Literature summary for 3.2.1.35 extracted from

  • Sunitha, K.; Suresh, P.; Santhosh, M.S.; Hemshekhar, M.; Thushara, R.M.; Marathe, G.K.; Thirunavukkarasu, C.; Kemparaju, K.; Kumar, M.S.; Girish, K.S.
    Inhibition of hyaluronidase by N-acetyl cysteine and glutathione: role of thiol group in hyaluronan protection (2013), Int. J. Biol. Macromol., 55, 39-46.
    View publication on PubMed
Search for more literature for 3.2.1.35

Inhibitors

Inhibitors Comment Organism Structure
glutathione non-competitive Apis mellifera
glutathione non-competitive Bos taurus
glutathione non-competitive Echis carinatus
glutathione non-competitive, complete inhibition at 1.8 mg/ml Homo sapiens
N-acetyl-L-cysteine non-competitive Apis mellifera
N-acetyl-L-cysteine non-competitive Bos taurus
N-acetyl-L-cysteine non-competitive Echis carinatus
N-acetyl-L-cysteine non-competitive, complete inhibition at 1.8 mg/ml Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
 Apis mellifera
-
-

Organism

Organism UniProt Comment Textmining
Apis mellifera Q08169
-
-
Bos taurus
-
-
-
Echis carinatus
-
-
-
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
serum
-
 Homo sapiens
-
testis
-
 Bos taurus
-
venom
-
 Echis carinatus
-
venom
-
 Apis mellifera
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
hyaluronic acid + H2O
-
 Homo sapiens ?
-
 ?
hyaluronic acid + H2O
-
 Bos taurus ?
-
 ?
hyaluronic acid + H2O
-
 Echis carinatus ?
-
 ?
hyaluronic acid + H2O
-
 Apis mellifera ?
-
 ?

Synonyms

Synonyms Comment Organism
HAase
-
 Homo sapiens
HAase
-
 Bos taurus
HAase
-
 Echis carinatus
HAase
-
 Apis mellifera
hyaluronidase
-
 Homo sapiens
hyaluronidase
-
 Bos taurus
hyaluronidase
-
 Echis carinatus
hyaluronidase
-
 Apis mellifera

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
4
-
 in 0.2 M sodium acetate buffer pH 5.5 containing 0.15 M NaCl at 37°C Bos taurus N-acetyl-L-cysteine