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Literature summary for 3.2.1.35 extracted from

  • Chatel, A.; Hemming, R.; Hobert, J.; Natowicz, M.R.; Triggs-Raine, B.; Merz, D.C.
    The C. elegans hyaluronidase: a developmentally significant enzyme with chondroitin-degrading activity at both acidic and neutral pH (2010), Matrix Biol., 29, 494-502.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Caenorhabditis elegans
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Synonyms

Synonyms Comment Organism
Hya-1
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Caenorhabditis elegans

General Information

General Information Comment Organism
physiological function generation of a deletion mutant in the Caenorhabditis elegans orthologue of mammalian hyaluronidase, Hya-1. Mutant animals are viable and grossly normal, but exhibit defects in vulval morphogenesis and egg-laying and show increased staining with alcian blue, consistent with an accumulation of glycosaminoglycan. A hya-1::GFP reporter is expressed in a restricted pattern in somatic tissues of the animal with strongest expression in the intestine, the PLM sensory neurons and the vulva. Total protein extracts from wild-type animals exhibit chondroitin-degrading but not hyaluronan-degrading activity. Chondroitinase activities are observed at both neutral and acidic pH conditions while both neutral and acidic activities are absent in extracts from Hya-1 mutant strains Caenorhabditis elegans