Organism | UniProt | Comment | Textmining |
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Caenorhabditis elegans | - |
- |
- |
Synonyms | Comment | Organism |
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Hya-1 | - |
Caenorhabditis elegans |
General Information | Comment | Organism |
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physiological function | generation of a deletion mutant in the Caenorhabditis elegans orthologue of mammalian hyaluronidase, Hya-1. Mutant animals are viable and grossly normal, but exhibit defects in vulval morphogenesis and egg-laying and show increased staining with alcian blue, consistent with an accumulation of glycosaminoglycan. A hya-1::GFP reporter is expressed in a restricted pattern in somatic tissues of the animal with strongest expression in the intestine, the PLM sensory neurons and the vulva. Total protein extracts from wild-type animals exhibit chondroitin-degrading but not hyaluronan-degrading activity. Chondroitinase activities are observed at both neutral and acidic pH conditions while both neutral and acidic activities are absent in extracts from Hya-1 mutant strains | Caenorhabditis elegans |