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Literature summary for 3.2.1.35 extracted from

  • Kaessler, A.; Olgen, S.; Jose, J.
    Autodisplay of catalytically active human hyaluronidase hPH-20 and testing of enzyme inhibitors (2011), Eur. J. Pharm. Sci., 42, 138-147.
    View publication on PubMed
Search for more literature for 3.2.1.35

Protein Variants

Protein Variants Comment Organism
additional information expression as PH-20-autotransporter fusion protein for cell surface display in Escherichia coli F470, a strain missing the O-polysaccharide of LPS, yields cells with sufficient hyaluronidase activity Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
6-palmitoyl-L-ascorbic acid 0.005 mM, 95% inhibition at pH 7.0 Bos taurus
6-palmitoyl-L-ascorbic acid 0.005 mM, 93% inhibition at pH 7.0 Homo sapiens
additional information inhibition data for human and bovine enzyme differ, bovine enzyme is not applicable as an alternative to human PH-20 Bos taurus
N-(4-chlorobenzyl)-1-(4-fluorobenzyl)-1H-indole-3-carboxamide 0.05 mM, 66% inhibition at pH 7.0 Bos taurus
N-(4-chlorobenzyl)-1-(4-fluorobenzyl)-1H-indole-3-carboxamide 0.05 mM, 21% inhibition at pH 7.0 Homo sapiens
N-(4-fluorobenzyl)-1-benzyl-1H-indole-2-carboxamide 0.05 mM, 80% inhibition at pH 7.0 Bos taurus
N-(4-fluorobenzyl)-1-benzyl-1H-indole-2-carboxamide 0.05 mM, 61% inhibition at pH 7.0 Homo sapiens

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
testis
-
 Bos taurus
-

Synonyms

Synonyms Comment Organism
PH-20
-
 Homo sapiens