Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.2.1.35 extracted from

  • Lokeshwar, V.B.; Schroeder, G.L.; Carey, R.I.; Soloway, M.S.; Iida, N.
    Regulation of hyaluronidase activity by alternative mRNA splicing (2002), J. Biol. Chem., 277, 33654-33663.
    View publication on PubMed
Search for more literature for 3.2.1.35

Application

Application Comment Organism
diagnostics increased concentration of HYAL1-type enzyme correlates with tumour progression and is a marker for grade (G) 2 or 3 bladder cancer Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
DNA and amino acid sequence determination and analysis, in vitro translation Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
hyaluronan + H2O Homo sapiens complete degradation, absolutely specific for ?
-
 ?
additional information Homo sapiens alternative splicing controls the cellular expression of enzymatically active hyaluronidase ?
-
 ?
additional information Homo sapiens increased concentration of HYAL1-type enzyme correlates with tumour progression and is a marker for grade (G) 2 or 3 bladder cancer ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 wild-type isozyme HYAL1
-
Homo sapiens O43820 isozyme splice variant HYAL3v1
-
Homo sapiens O43820 isozyme splice variant HYAL3v2
-
Homo sapiens O43820 isozyme splice variant HYAL3v3
-
Homo sapiens O43820 wild-type isozyme HYAL3wt
-
Homo sapiens Q12794 isozyme splice variant HYAL1v1
-
Homo sapiens Q12794 isozyme splice variant HYAL1v2
-
Homo sapiens Q12794 isozyme splice variant HYAL1v3
-
Homo sapiens Q12794 isozyme splice variant HYAL1v4
-
Homo sapiens Q12794 isozyme splice variant HYAL1v5
-

Source Tissue

Source Tissue Comment Organism Textmining
bladder tissue and cells Homo sapiens
-
bladder carcinoma cell
-
 Homo sapiens
-
bladder tumour cell G1 tumour tissue Homo sapiens
-
bladder tumour cell G2 and G3 tumour tissues, and invasive tumour cells Homo sapiens
-
kidney
-
 Homo sapiens
-
additional information tissue distribution Homo sapiens
-
prostate
-
 Homo sapiens
-
prostate cancer cell
-
 Homo sapiens
-
prostate carcinoma cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
hyaluronan + H2O
-
 Homo sapiens ?
-
 ?
hyaluronan + H2O complete degradation, absolutely specific for Homo sapiens ?
-
 ?
hyaluronan + H2O wild-type isozyme HYAL1 sequence, amino acid residues 301-330, is critical for hyaluronidase activity Homo sapiens ?
-
 ?
additional information the splice variant is enzymatically inactive Homo sapiens ?
-
 ?
additional information alternative splicing controls the cellular expression of enzymatically active hyaluronidase Homo sapiens ?
-
 ?
additional information increased concentration of HYAL1-type enzyme correlates with tumour progression and is a marker for grade (G) 2 or 3 bladder cancer Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
HYAL1
-
 Homo sapiens
HYAL3
-
 Homo sapiens
hyaluronidase
-
 Homo sapiens