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Literature summary for 3.2.1.35 extracted from
- Expression of hyaluronan synthases (HAS1-3) and hyaluronidases (HYAL1-2) in serous ovarian carcinomas: Inverse correlation between HYAL1 and hyaluronan content (2009), BMC Cancer, 9, 143.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q12794 | - |
- |
| Homo sapiens | Q12891 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| ovarian serous carcinoma cell | - |
Homo sapiens | - |
| ovary | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| hyaluronan + 2 H2O | - |
Homo sapiens | N-acetyl-beta-D-glucosamine + D-glucuronate + ? | - |
? |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| HYAL1 | - |
Homo sapiens |
| Hyal2 | - |
Homo sapiens |
| hyaluronidase | - |
Homo sapiens |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Homo sapiens | the median of isoform HYAL1 mRNA level is 69% lower in grade 3 serous ovarian cancers compared to normal ovaries | down |
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