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Literature summary for 3.2.1.35 extracted from

  • Reese, K.L.; Aravindan, R.G.; Griffiths, G.S.; Shao, M.; Wang, Y.; Galileo, D.S.; Atmuri, V.; Triggs-Raine, B.L.; Martin-Deleon, P.A.
    Acidic hyaluronidase activity is present in mouse sperm and is reduced in the absence of SPAM1: evidence for a role for hyaluronidase 3 in mouse and human sperm (2010), Mol. Reprod. Dev., 77, 759-772.
    View publication on PubMedView publication on EuropePMC

Localization

Localization Comment Organism GeneOntology No. Textmining
acrosome mouse isoforms are differentially distributed in the soluble, membrane, and acrosome-related fraction, where they are most abundant Mus musculus
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plasma membrane mouse isoforms are differentially distributed in the soluble, membrane, and acrosome-related fraction, where they are most abundant. Protein resides in the membrane over the sperm head and midpiece Mus musculus 5886
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plasma membrane protein resides in the membrane over the sperm head and midpiece Mus musculus 5886
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soluble mouse isoforms are differentially distributed in the soluble, membrane, and acrosome-related fraction, where they are most abundant Mus musculus
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Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
43000
-
x * 43000 and x * 47000, SDS-PAGE Mus musculus
47000
-
x * 43000 and x * 47000, SDS-PAGE Mus musculus
47000
-
x * 47000 and x * 55000, SDS-PAGE Mus musculus
55000
-
x * 47000 and x * 55000, SDS-PAGE Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
epididymis Hyal3 is expressed in epididymal tissue/fluid, from where it is acquired by caudal mouse sperm in vitro Mus musculus
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sperm Hyal3 is expressed in epididymal tissue/fluid, from where it is acquired by caudal mouse sperm in vitro Mus musculus
-

Subunits

Subunits Comment Organism
? x * 43000 and x * 47000, SDS-PAGE Mus musculus
? x * 47000 and x * 55000, SDS-PAGE Mus musculus

Synonyms

Synonyms Comment Organism
HYAL3
-
Mus musculus
HYase
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Mus musculus

General Information

General Information Comment Organism
physiological function although fully fertile, Hyal3 null sperm shows delayed cumulus penetration and reduced acrosomal exocytosis. Spam1 null mutants lacking sperm adhesion molecule 1 have significantly diminished Hyal3 activity Mus musculus