Information on EC 3.2.1.3 - glucan 1,4-alpha-glucosidase

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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea

EC NUMBER
COMMENTARY hide
3.2.1.3
-
RECOMMENDED NAME
GeneOntology No.
glucan 1,4-alpha-glucosidase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
Hydrolysis of terminal (1->4)-linked alpha-D-glucose residues successively from non-reducing ends of the chains with release of beta-D-glucose
show the reaction diagram
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
hydrolysis
hydrolysis of O-glycosyl bond
-
-
exohydrolysis
-
O-glycosyl bond hydrolysis
-
-
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
glycogen degradation II
-
-
glycogen metabolism
-
-
Metabolic pathways
-
-
Starch and sucrose metabolism
-
-
SYSTEMATIC NAME
IUBMB Comments
4-alpha-D-glucan glucohydrolase
Most forms of the enzyme can rapidly hydrolyse 1,6-alpha-D-glucosidic bonds when the next bond in the sequence is 1,4, and some preparations of this enzyme hydrolyse 1,6- and 1,3-alpha-D-glucosidic bonds in other polysaccharides. This entry covers all such enzymes acting on polysaccharides more rapidly than on oligosaccharides. EC 3.2.1.20 alpha-glucosidase, from mammalian intestine, can catalyse similar reactions.
CAS REGISTRY NUMBER
COMMENTARY hide
9032-08-0
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
-
-
Manually annotated by BRENDA team
Arachniotus citrinus
-
-
-
Manually annotated by BRENDA team
Arachniotus sp.
-
-
-
Manually annotated by BRENDA team
strain 466
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
strain X-100
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
strain NR 15-1, the traditional Korean Nuruk fungi, two isozymes GA-I and GA-II
-
-
Manually annotated by BRENDA team
strain NR 15-1, the traditional Korean Nuruk fungi, two isozymes GA-I and GA-II
-
-
Manually annotated by BRENDA team
two isozymes
-
-
Manually annotated by BRENDA team
two isozymes
-
-
Manually annotated by BRENDA team
strain A-7420
-
-
Manually annotated by BRENDA team
strain B1
SwissProt
Manually annotated by BRENDA team
strain NIAB 280
-
-
Manually annotated by BRENDA team
strain NRRL 330
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
strain 4
-
-
Manually annotated by BRENDA team
strain NA-170
-
-
Manually annotated by BRENDA team
strain NA-770
-
-
Manually annotated by BRENDA team
strains 643.92 and 127.49, high identity with Aspergillus niger strain DSM 823
-
-
Manually annotated by BRENDA team
AHU 9627
-
-
Manually annotated by BRENDA team
Athelia rolfsii AHU 9627
AHU 9627
-
-
Manually annotated by BRENDA team
gene APGA1
UniProt
Manually annotated by BRENDA team
strain J38
-
-
Manually annotated by BRENDA team
strain J38
-
-
Manually annotated by BRENDA team
LS3
-
-
Manually annotated by BRENDA team
CBS 6678
-
-
Manually annotated by BRENDA team
-
UniProt
Manually annotated by BRENDA team
Cephalosporium charticola
-
-
-
Manually annotated by BRENDA team
Cephalosporium eichhorniae
-
-
-
Manually annotated by BRENDA team
strain CT2, a soil-borne thermophilic fungus, gene gla
SwissProt
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
Endomycopsis fibuligera
Endomycopsis fibuligera Y1
strain Y1
-
-
Manually annotated by BRENDA team
endophytic fungus EF6
isolated from Thai medicinal plants
-
-
Manually annotated by BRENDA team
Halolactibacillus sp.
soil isolate
-
-
Manually annotated by BRENDA team
soil isolate
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
CBS 5608 mutant
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
nov-sp. F-1; strain F-1, two active forms
-
-
Manually annotated by BRENDA team
strain F-1, two active forms
-
-
Manually annotated by BRENDA team
Monascus rubiginosus
enzyme forms E1, E2, E3, E4, E4' and E5
-
-
Manually annotated by BRENDA team
Monascus sp.
Monascus sp. 3403
No. 3403
-
-
Manually annotated by BRENDA team
Mucor rouxians
-
-
-
Manually annotated by BRENDA team
Mucor rouxianus
-
-
-
Manually annotated by BRENDA team
strain M1
-
-
Manually annotated by BRENDA team
strain M1
-
-
Manually annotated by BRENDA team
AHU 9417
-
-
Manually annotated by BRENDA team
CBS 6389
-
-
Manually annotated by BRENDA team
CBS 6389
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
-
UniProt
Manually annotated by BRENDA team
two enzymes AmyC and AmyD, genes amyC or amyD
-
-
Manually annotated by BRENDA team
1ab
-
-
Manually annotated by BRENDA team
var. diastaticus
-
-
Manually annotated by BRENDA team
Glu1 precursor; strain HUT 7212
SwissProt
Manually annotated by BRENDA team
Glu-1.1 precursor; strain IFO 0111
SwissProt
Manually annotated by BRENDA team
Schwanniomyces castellii
-
-
-
Manually annotated by BRENDA team
strain R-47
-
-
Manually annotated by BRENDA team
CR19
-
-
Manually annotated by BRENDA team
ML-M
-
-
Manually annotated by BRENDA team
soil-borne thermophilic fungus, synonym, allescheria terrestris
-
-
Manually annotated by BRENDA team
i.e. Hypocrea lixii, strain CECT 2413, gene gla66
SwissProt
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
additional information
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
3-alpha-maltosylglucose + H2O
?
show the reaction diagram
-
-
-
-
?
4 glucose
glucooligosaccharide + 3 H2O
show the reaction diagram
4-alpha-nigerosyl-glucose + H2O
?
show the reaction diagram
-
-
-
-
?
4-methylumbelliferyl-alpha-D-glucoside + H2O
?
show the reaction diagram
-
-
-
-
?
4-nitrophenyl alpha-D-glucopyranoside + H2O
4-nitrophenyl + D-glucose
show the reaction diagram
-
-
-
-
?
4-nitrophenyl alpha-D-glucopyranoside + H2O
D-glucose + 4-nitrophenol
show the reaction diagram
-
-
-
-
?
4-nitrophenyl beta-D-glucopyranoside + H2O
4-nitrophenol + beta-D-glucose
show the reaction diagram
-
-
-
-
?
4-nitrophenyl D-glucose
4-nitrophenol + D-glucose
show the reaction diagram
-
-
-
-
-
4-nitrophenyl-beta-D-glucoside + H2O
4-nitrophenol + beta-D-glucose
show the reaction diagram
-
-
-
-
?
4-nitrophenyl-D-glucopyranoside + H2O
4-nitrophenol + D-glucose
show the reaction diagram
-
-
-
-
?
6-alpha-maltosylglucose + H2O
?
show the reaction diagram
-
-
-
-
?
alpha-alpha-trehalose + H2O
alpha-D-glucose
show the reaction diagram
-
-
-
-
?
alpha-cyclodextrin + H2O
?
show the reaction diagram
-
-
-
-
?
alpha-cyclodextrin + H2O
alpha-cyclodextrin + beta-D-glucose
show the reaction diagram
alpha-cyclodextrin + H2O
glucose
show the reaction diagram
alpha-D-glucopyranosyl fluoride + H2O
?
show the reaction diagram
-
-
-
-
?
alpha-limit dextrin + H2O
?
show the reaction diagram
-
-
-
-
?
amylodextrin + H2O
?
show the reaction diagram
-
amylodextrin DP-15
-
-
?
amylopectin + H2O
?
show the reaction diagram
amylopectin + H2O
amylopectin + beta-D-glucose
show the reaction diagram
amylopectin + H2O
beta-D-glucose
show the reaction diagram
amylopectin + H2O
D-glucose
show the reaction diagram
amylose + H2O
?
show the reaction diagram
amylose + H2O
amylose + beta-D-glucose
show the reaction diagram
amylose + H2O
beta-D-glucose
show the reaction diagram
amylose + H2O
D-glucose
show the reaction diagram
amylose + H2O
glucose
show the reaction diagram
beta-cyclodextrin + H2O
?
show the reaction diagram
beta-cyclodextrin + H2O
beta-cyclodextrin + beta-D-glucose
show the reaction diagram
-
-
-
-
?
curcumin + beta-D-glucose
curcuminyl bis-alpha-D-glucoside + 6-O-curcuminyl bis-D-glucose + curcuminyl bis-beta-D-glucoside
show the reaction diagram
Rhizopus sp.
-
i.e. 1E,6E-1,7-di(4-hydroxy-3-methoxy-phenyl)-1,6-heptadiene-3,5-dione
-
-
?
curcumin + D-mannitol
1-O-curcuminyl bis-D-mannitol
show the reaction diagram
Rhizopus sp.
-
i.e. 1E,6E-1,7-di(4-hydroxy-3-methoxy-phenyl)-1,6-heptadiene-3,5-dione
-
-
?
curcumin + D-mannose
curcuminyl bis-alpha-D-mannoside + curcuminyl bis-maltoside + 6-O-curcuminyl bis-maltose + 6''-O-curcuminyl bis-maltose
show the reaction diagram
Rhizopus sp.
-
i.e. 1E,6E-1,7-di(4-hydroxy-3-methoxy-phenyl)-1,6-heptadiene-3,5-dione
-
-
?
curcumin + sucrose
1-O-curcuminyl bis-sucrose + 6''-O-curcuminyl bis-sucrose + 6-O-curcuminyl bis-sucrose
show the reaction diagram
Rhizopus sp.
-
i.e. 1E,6E-1,7-di(4-hydroxy-3-methoxy-phenyl)-1,6-heptadiene-3,5-dione
-
-
?
curcumin-bis-alpha-D-glucoside + H2O
curcumin + beta-D-glucose
show the reaction diagram
Rhizopus sp.
-
the enzyme also performs glucosylation of curcumin-bis-alpha-D-glucoside in the reverse reaction
-
-
r
D-glucooligomer + H2O
D-glucose
show the reaction diagram
-
-
-
-
-
D-malto-oligosaccharides + H2O
?
show the reaction diagram
-
low activity
-
-
?
dextran + H2O
?
show the reaction diagram
dextrin + 6 H2O
7 beta-D-glucose
show the reaction diagram
dextrin + 6 H2O
7 D-glucose
show the reaction diagram
dextrin + H2O
?
show the reaction diagram
dextrin + H2O
dextrin + beta-D-glucose
show the reaction diagram
-
-
-
-
?
eugenol + beta-D-glucose
eugenyl alpha-D-glucoside + 6-O-eugenyl D-glucose + eugenyl beta-D-glucoside
show the reaction diagram
Rhizopus sp.
-
i.e. 4-allyl-2-methoxy phenol
-
-
?
eugenol + D-mannitol
1-O-eugenyl mannitol
show the reaction diagram
Rhizopus sp.
-
i.e. 4-allyl-2-methoxy phenol
-
-
?
eugenol + D-mannose
eugenyl alpha-D-mannoside
show the reaction diagram
Rhizopus sp.
-
i.e. 4-allyl-2-methoxy phenol
-
-
?
eugenol + maltose
eugenyl maltoside + 6-O-eugenyl maltose + 6''-O-eugenyl maltose
show the reaction diagram
Rhizopus sp.
-
-
-
-
-
eugenol + sucrose
1-O-eugenyl sucrose + 6-O-eugenyl sucrose + 6''-O-eugenyl sucrose
show the reaction diagram
Rhizopus sp.
-
i.e. 4-allyl-2-methoxy phenol
-
-
?
gamma-cyclodextrin + H2O
gamma-cyclodextrin + beta-D-glucose
show the reaction diagram
-
-
-
-
?
glycogen + 3 H2O
4 beta-D-glucose
show the reaction diagram
glycogen + H2O
?
show the reaction diagram
glycogen + H2O
D-glucose
show the reaction diagram
-
-
-
-
?
glycogen + H2O
glucose
show the reaction diagram
glycogen + H2O
glycogen + beta-D-glucose
show the reaction diagram
guaiacol-alpha-D-glucoside + H2O
guaiacol + beta-D-glucose
show the reaction diagram
Rhizopus sp.
-
the enzyme also performs glucosylation of guaiacol-alpha-D-glucoside in the reverse reaction
-
-
r
isomaltoheptaose + H2O
?
show the reaction diagram
-
-
-
-
?
isomaltoheptaose + H2O
beta-D-glucose
show the reaction diagram
-
-
-
-
?
isomaltohexaose + H2O
?
show the reaction diagram
-
-
-
-
?
isomaltohexaose + H2O
beta-D-glucose
show the reaction diagram
-
-
-
-
?
isomaltopentaose + H2O
?
show the reaction diagram
isomaltopentaose + H2O
beta-D-glucose
show the reaction diagram
-
-
-
-
?
isomaltose
isomaltooligosaccharide
show the reaction diagram
isomaltose + H2O
?
show the reaction diagram
-
assay at pH 5.5, 40C
-
-
?
isomaltose + H2O
beta-D-glucose
show the reaction diagram
isomaltose + H2O
D-glucose + ?
show the reaction diagram
-
assay at pH 5.0, 75C, reaction stopped by boiling at 100C for 3 min
-
-
?
isomaltose + H2O
glucose
show the reaction diagram
isomaltotetraose + H2O
?
show the reaction diagram
isomaltotetraose + H2O
beta-D-glucose
show the reaction diagram
-
-
-
-
?
isomaltotriose + H2O
?
show the reaction diagram
isomaltotriose + H2O
? + beta-D-glucose
show the reaction diagram
-
-
-
-
?
isomaltotriose + H2O
beta-D-glucose
show the reaction diagram
-
-
-
-
?
kojibiose + H2O
alpha-D-glucose
show the reaction diagram
-
-
-
-
?
maltodextrin + H2O
?
show the reaction diagram
-
corn maltodextrin
-
-
?
maltodextrin + H2O
beta-D-glucose
show the reaction diagram
-
-
-
-
?
maltodextrin + H2O
beta-glucose
show the reaction diagram
-
-
-
-
maltodextrin + H2O
D-glucose
show the reaction diagram
-
from corn mash
-
-
?
maltodextrin + H2O
maltodextrin + beta-D-glucose
show the reaction diagram
-
during incubation 5-(hydroxymethyl)-2-furfuraldehyde is released, resulting in a glycated enzyme
-
-
?
maltoheptaose + 6 H2O
7 beta-D-glucose
show the reaction diagram
maltoheptaose + H2O
?
show the reaction diagram
maltoheptaose + H2O
beta-D-glucose
show the reaction diagram
maltoheptaose + H2O
D-glucose + ?
show the reaction diagram
-
assay at pH 5.0, 75C, reaction stopped by boiling at 100C for 3 min
-
-
?
maltoheptaose + H2O
maltohexaose + D-glucose
show the reaction diagram
maltohexaose + 5 H2O
6 beta-D-glucose
show the reaction diagram
maltohexaose + H2O
?
show the reaction diagram
maltohexaose + H2O
beta-D-glucose
show the reaction diagram
maltohexaose + H2O
D-glucose + ?
show the reaction diagram
-
assay at pH 5.0, 75C, reaction stopped by boiling at 100C for 3 min
-
-
?
maltohexaose + H2O
maltopentaose + beta-D-glucose
show the reaction diagram
-
-
-
-
?
maltononaose + H2O
maltooctaose + beta-D-glucose
show the reaction diagram
-
-
-
-
?
maltooctaose + H2O
maltoheptaose + beta-D-glucose
show the reaction diagram
maltooligomers + H2O
? + beta-D-glucose
show the reaction diagram
substrate specificity
-
-
r
maltooligosaccharide + H2O
beta-D-glucose
show the reaction diagram
maltooligosaccharides + H2O
maltooligosaccharides + beta-D-glucose
show the reaction diagram
maltopentadecaose + H2O
maltotetradecaose + beta-D-glucose
show the reaction diagram
-
low activity
-
-
?
maltopentaose + 4 H2O
5 beta-D-glucose
show the reaction diagram
maltopentaose + H2O
?
show the reaction diagram
maltopentaose + H2O
beta-D-glucose
show the reaction diagram
maltopentaose + H2O
D-glucose + ?
show the reaction diagram
-
assay at pH 5.0, 75C, reaction stopped by boiling at 100C for 3 min
-
-
?
maltopentaose + H2O
maltotetraose + beta-D-glucose
show the reaction diagram
maltose + H2O
2 beta-D-glucose
show the reaction diagram
maltose + H2O
2 D-glucose
show the reaction diagram
-
-
-
-
?
maltose + H2O
?
show the reaction diagram
maltose + H2O
beta-D-glucose
show the reaction diagram
maltose + H2O
beta-D-glucoseglucose
show the reaction diagram
-
2% of activity with soluble starch from potato
-
-
?
maltose + H2O
D-glucose
show the reaction diagram
maltose + H2O
D-glucose + ?
show the reaction diagram
maltose + H2O
glucose
show the reaction diagram
maltotetraose + 3 H2O
4 beta-D-glucose
show the reaction diagram
-
-
-
?
maltotetraose + H2O
?
show the reaction diagram
maltotetraose + H2O
beta-D-glucose
show the reaction diagram
maltotetraose + H2O
D-glucose
show the reaction diagram
-
-
-
?
maltotetraose + H2O
D-glucose + ?
show the reaction diagram
-
assay at pH 5.0, 75C, reaction stopped by boiling at 100C for 3 min
-
-
?
maltotetraose + H2O
maltotriose + beta-D-glucose
show the reaction diagram
maltotriose + 2 H2O
3 beta-D-glucose
show the reaction diagram
maltotriose + H2O
?
show the reaction diagram
-
-
-
-
?
maltotriose + H2O
D-glucose
show the reaction diagram
-
-
-
?
maltotriose + H2O
D-glucose + ?
show the reaction diagram
-
assay at pH 5.0, 75C, reaction stopped by boiling at 100C for 3 min
-
-
?
maltotriose + H2O
glucose
show the reaction diagram
maltotriose + H2O
maltose + beta-D-glucose
show the reaction diagram
methyl-alpha-D-glucoside + H2O
methanol + alpha-D-glucose
show the reaction diagram
nigerose + H2O
2 alpha-D-glucose
show the reaction diagram
p-nitrophenyl alpha-D-glucoside + H2O
p-nitrophenol + alpha-D-glucose
show the reaction diagram
p-nitrophenyl-alpha-D-glucopyranoside + H2O
p-nitrophenol + D-glucose
show the reaction diagram
p-nitrophenyl-alpha-D-glucose + H2O
p-nitrophenol + alpha-D-glucose
show the reaction diagram
-
12% of activity with starch
-
-
?
panose + H2O
?
show the reaction diagram
pectin + H2O
pectin + beta-D-glucose
show the reaction diagram
-
-
-
-
?
phenyl alpha-glucoside + H2O
?
show the reaction diagram
-
-
-
-
-
phenyl alpha-maltoside + H2O
glucose + phenyl alpha-glucoside
show the reaction diagram
pullulan + H2O
?
show the reaction diagram
pullulan + H2O
beta-D-glucose
show the reaction diagram
-
182% of activity with soluble starch
-
-
?
pullulan + H2O
pullulan + beta-D-glucose
show the reaction diagram
-
exoglycosidic hydrolysis of terminal glucose
-
-
?
raw potato starch + H2O
?
show the reaction diagram
-
-
-
?
soluble potato starch + H2O
?
show the reaction diagram
soluble starch + H2O
?
show the reaction diagram
soluble starch + H2O
beta-D-glucose
show the reaction diagram
starch + 2O
beta-D-glucose
show the reaction diagram
-
-
-
?
starch + H2O
?
show the reaction diagram
starch + H2O
beta-D-glucose
show the reaction diagram
starch + H2O
D-glucose
show the reaction diagram
starch + H2O
D-glucose + ?
show the reaction diagram
starch + H2O
glucose
show the reaction diagram
starch + H2O
glucose + ?
show the reaction diagram
-
catalyses the hydrolysis of the alpha-1,4 glycosidic bonds of starch
-
-
?
starch + H2O
starch + beta-D-glucose
show the reaction diagram
sucrose + H2O
D-glucose + D-fructose
show the reaction diagram
trehalose + H2O
D-glucose
show the reaction diagram
-
-
-
-
?
turanose + H2O
D-fructose + D-glucose
show the reaction diagram
-
-
-
-
?
xylan + H2O
?
show the reaction diagram
-
-
-
-
?
xylan + H2O
xylan + beta-D-glucose
show the reaction diagram
-
-
-
-
?
additional information
?
-