Information on EC 1.13.11.34 - arachidonate 5-lipoxygenase

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The expected taxonomic range for this enzyme is: Eukaryota

EC NUMBER
COMMENTARY
1.13.11.34
-
RECOMMENDED NAME
GeneOntology No.
arachidonate 5-lipoxygenase
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT ACCESSION NO.
LITERATURE
(6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyicosa-6,8,11,14-tetraenoate = leukotriene A4 + H2O
show the reaction diagram
(1b)
-
-
-
arachidonate + O2 = (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyicosa-6,8,11,14-tetraenoate
show the reaction diagram
(1a)
-
-
-
arachidonate + O2 = leukotriene A4 + H2O
show the reaction diagram
overall reaction
-
-
-
PATHWAY
KEGG Link
MetaCyc Link
Arachidonic acid metabolism
-
lipoxin biosynthesis
-
Metabolic pathways
-
SYSTEMATIC NAME
IUBMB Comments
arachidonate:oxygen 5-oxidoreductase
-
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
5-lipoxygenase
P09917
-
5-lipoxygenase
-
-
5-lipoxygenase
P48999
-
5-lipoxygenase
P12527
-
5-lipoxygenase
-
-
5-LO
-
-
-
-
5-LO
P09917
-
5-LO
P48999
-
5-LO
Mus musculus C57BL/6J
P48999
-
-
5-LOX
-
-
5-LOX
P12527
-
5-LOX
-
-
5DELTA-lipoxygenase
-
-
-
-
5LOX-1
-
-
ALOX5
-
-
arachidonate 5-LO
-
-
arachidonate:oxygen oxidoreductase
-
-
arachidonic 5-lipoxygenase
-
-
-
-
arachidonic acid 5-lipoxygenase
-
-
-
-
C-5-lipoxygenase
-
-
-
-
DELTA5-lipoxygenase
-
-
-
-
H5-LO
-
-
leukotriene A4 synthase
-
-
-
-
leukotriene-A4 synthase
-
-
-
-
lipoxygenase 15
-
-
lipoxygenase 5
-
-
lipoxygenase-1
-
-
LO-1
-
-
LOX-5
-
-
LTA synthase
-
-
-
-
LTA4 synthase
-
-
LTA4 synthase
P09917
-
oxygenase, arachidonate, 5-lip-
-
-
-
-
PMNL 5-lipoxygenase
-
-
CAS REGISTRY NUMBER
COMMENTARY
80619-02-9
-
ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
C57BL/6 mice
-
-
Manually annotated by BRENDA team
C57BL/6 mice
UniProt
Manually annotated by BRENDA team
C57BL/6, 129Sv mice
-
-
Manually annotated by BRENDA team
C57BL/6J mice
UniProt
Manually annotated by BRENDA team
Mus musculus C57BL/6J
C57BL/6J mice
UniProt
Manually annotated by BRENDA team
TURNOVER NUMBER [1/s]
TURNOVER NUMBER MAXIMUM[1/s]
SUBSTRATE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
25
-
arachidonic acid
-
-
138
-
linoleic acid
-
-
kcat/KM VALUE [1/mMs-1]
kcat/KM VALUE [1/mMs-1] Maximum
SUBSTRATE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
IMAGE
31000
-
arachidonic acid
-
at 25°C
7114