EC Number   |
Localization |
GeneOntology No. |
Reference |
|---|
    1.13.11.34 | cytoplasm |
mainly |
GO:0005737 AmiGO QuickGO |
687058 |
| 1.13.11.34 | cytosol |
- |
GO:0005829 AmiGO QuickGO |
439442, 439461, 439470, 686278, 690170, 741961, 742001, 742210 |
| 1.13.11.34 | cytosol |
being a mobile enzyme, 5-LO migrates from the cytosol to the nuclear envelope |
GO:0005829 AmiGO QuickGO |
741975 |
| 1.13.11.34 | cytosol |
Ca2+ induces the translocation of 5-LO from a soluble compartment to nuclear structures, where 5-LO co-localizes with 5-LO activating protein, FLAP |
GO:0005829 AmiGO QuickGO |
689872 |
| 1.13.11.34 | cytosol |
in basophilic leukemia cells translocation of cytosolic enzyme and the soluble nuclear enzyme to the nuclear envelope where it interacts with 5-lipoxygenase-activating protein |
GO:0005829 AmiGO QuickGO |
439467 |
| 1.13.11.34 | cytosol |
in resting cells, 5LO resides either in the cytosol (e.g. in neutrophils, eosinophils, peritoneal macrophages) or in a nuclear soluble compartment associated with chromatin (e.g. in alveolar macrophages, Langerhans cells, basophilic leukemia cells) |
GO:0005829 AmiGO QuickGO |
711100 |
| 1.13.11.34 | cytosol |
polymorphonuclear leukocytes: translocation of cytosolic enzyme to the nuclear envelope where it interacts with 5-lipoxygenase-activating protein |
GO:0005829 AmiGO QuickGO |
439467 |
| 1.13.11.34 | cytosol |
resides in the cytosol of resting neutrophils from females |
GO:0005829 AmiGO QuickGO |
704997 |
| 1.13.11.34 | cytosol |
when leukocytes are activated to produce leukotrienes, 5-LO moves from the cytosol to the perinuclear membrane |
GO:0005829 AmiGO QuickGO |
712666 |
| 1.13.11.34 | membrane |
calcium binds to allosteric sites in the 5-LOX N-terminal polycystin-1/lipoxygenase/alpha-toxin (PLAT) domain, promoting attachment to the membrane via conserved tryptophan residues that embed into the lipid bilayer |
GO:0016020 AmiGO QuickGO |
741898 |
