Literature summary for 1.13.11.34 extracted from

Walther, M.; Ivanov, I.; Myagkova, G.; Kuhn, H.
Alterations of lipoxygenase specificity by targeted substrate modification and site-directed mutagenesis (2001), Chem. Biol., 8, 779-790.

Search for more literature for 1.13.11.34

Cloned(Commentary)

Cloned (Comment)	Organism
wild-type and mutant enzyme F359W/A424I/N425M/A603I, expression in Escherichia coli	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
F359W/A424I/N425M/A603I	15-lipoxygenating mutant	Homo sapiens
F359W/A424I/N425M/A603I	oxygenates polyenoic fatty acids containing C11=C12 and C14=C15 double bonds, C20:DELTA11,14,17, C20:DELTA11,14, C18:DELTA9,12, C18:DELTA6,9,12 and C18:DELTA9,12,15 which are not oxygenated by the wild-type enzyme. C20:DELTA5,8,11 that lacks the C11=C12 double bond is not oxygenated	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
arachidonate + O2	i.e. 5,8,11,14-eicosatetraenoic acid	Homo sapiens	(6E,8Z,11Z,14Z)-(5S)-hydroperoxyicosa-6,8,11,14-tetraenoate	-	?

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)