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Literature summary for 1.13.11.34 extracted from

  • Shirumalla R. , S.R.; Naruganahalli K. , N.K.; Dastidar S. , D.S.; Sattigeri , S.V.; Kaur , K.G.; Deb , D.C.; Gupta J. , G.J.; Salman , S.M.; Ray , R.A.
    RBx 7796: A novel inhibitor of 5-lipoxygenase (2006), Inflamm. Res., 55, 517-527.
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
1-O-dodecyl 2,3-O-isopropylidene-5,6-dideoxy-5-N-[4-(2-hydroxy-2-oxoethyl) phenylaminocarbonyl] amino-beta-L-gulofuranoside sodium salt competitive inhibitor, IC50: 0.0035 mM with recombinant enzyme, IC50: 0.005 mM with native enzyme Homo sapiens
zileuton IC50: 0.0038 mM with recombinant enzyme, IC50: 0.0011 mM with native enzyme Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0051
-
 arachidonate reaction mixture contains 1 mM DTT, 1 mM ATP, 2 mM CaCl2, and 0.01 mM indomethacin in phosphate buffered saline, at 37°C Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
neutrophil
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
arachidonate + O2
-
 Homo sapiens (6E,8Z,11Z,14Z)-(5S)-hydroperoxyicosa-6,8,11,14-tetraenoate
-
 ?

Synonyms

Synonyms Comment Organism
5-LO
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0011
-
 IC50: 0.0038 mM with recombinant enzyme, IC50: 0.0011 mM with native enzyme Homo sapiens zileuton
0.005
-
 competitive inhibitor, IC50: 0.0035 mM with recombinant enzyme, IC50: 0.005 mM with native enzyme Homo sapiens 1-O-dodecyl 2,3-O-isopropylidene-5,6-dideoxy-5-N-[4-(2-hydroxy-2-oxoethyl) phenylaminocarbonyl] amino-beta-L-gulofuranoside sodium salt