Activating Compound | Comment | Organism | Structure |
---|---|---|---|
5-lipoxygenase-activating protein | functional 5-LOX requires binding to 5-lipoxygenase-activating protein which helps 5-LOX binding to arachidonic acid at the nuclear membrane and enhances the efficiency of leukotriene synthesis | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nuclear membrane | - |
Homo sapiens | 31965 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
chondrocyte | osteoarthritic chondrocyte | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
5-lipoxygenase | - |
Homo sapiens |
5-LOX | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | 0.01 mM hydroxynonenal induces 5-LOX promoter activity significantly by 310% and 580% after 48 and 72 h of incubation, respectively. The addition of anti-transforming growth factor-beta1 antibody reduces hydroxynonenal-induced 5-LOX expression by 40% | up |