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Literature summary for 1.13.11.34 extracted from

  • Chen, S.H.; Fahmi, H.; Shi, Q.; Benderdour, M.
    Regulation of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase-activating protein/5-lipoxygenase by 4-hydroxynonenal in human osteoarthritic chondrocytes (2010), Arthritis Res. Ther., 12, R21.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
5-lipoxygenase-activating protein functional 5-LOX requires binding to 5-lipoxygenase-activating protein which helps 5-LOX binding to arachidonic acid at the nuclear membrane and enhances the efficiency of leukotriene synthesis Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
nuclear membrane
-
Homo sapiens 31965
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
chondrocyte osteoarthritic chondrocyte Homo sapiens
-

Synonyms

Synonyms Comment Organism
5-lipoxygenase
-
Homo sapiens
5-LOX
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens 0.01 mM hydroxynonenal induces 5-LOX promoter activity significantly by 310% and 580% after 48 and 72 h of incubation, respectively. The addition of anti-transforming growth factor-beta1 antibody reduces hydroxynonenal-induced 5-LOX expression by 40% up