EC Number   |
Application |
Reference |
|---|
    1.13.11.34 | drug development |
5-lipoxygenase (5-LOX) is a target for drug design. Due to its role in the production of inflammatory lipid mediators, 5-LOX is a target for the development of therapeutics for conditions as diverse as asthma, cardiovascular disease, pancreatic cancer, and traumatic brain injury |
741918 |
| 1.13.11.34 | drug development |
caffeoyl clusters are good lead compounds in the design and synthesis of more potent 5-lipoxygenase inhibitors |
702553 |
| 1.13.11.34 | drug development |
due to their high potency against 5-lipoxygenase and the marked efficacy in biological systems, benzo[g]indole-3-carboxylates may have potential as anti-inflammatory therapeutics |
705037 |
| 1.13.11.34 | drug development |
gender difference in biosynthesis of leukotrienes (inflammatory mediators) may lead to new possibilities regarding development and use of 5-lipoxygenase inhibitors |
704997 |
| 1.13.11.34 | drug development |
human 5-lipoxygenase is a well-validated target for anti-inflammatory therapy. Development of 5-LOX inhibitors with higher activities is highly required |
742067 |
| 1.13.11.34 | drug development |
pirinixic acid derivatives constitute a novel class of dual mPGES-1/5-lipoxygenase inhibitors with a promising pharmacologial profile and a potential for therapeutic use |
693577 |
| 1.13.11.34 | drug development |
the enzyme is a target in drug design for cancer therapy, inhibitors inclinical trials, overview |
686278 |
| 1.13.11.34 | drug development |
the enzyme is an emerging target in obesity, insulin resistance, and artherosclerosis |
-, 688231 |
| 1.13.11.34 | medicine |
direct 5-LO inhibitors are able to suppress the viability of various human tumour cells independently of 5-LO inhibition |
711633 |
| 1.13.11.34 | medicine |
powerful inhibitory properties of anthocyanins (delphinidin glycosides) towards lipoxygenases in relation to their currently known availability in human metabolism may in vivo prevent inflammatory diseases |
705797 |
