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Literature summary for 1.13.11.34 extracted from

  • Huang, L.S.; Kim, M.R.; Sok, D.E.
    Regulation of lipoxygenase activity by polyunsaturated lysophosphatidylcholines or their oxygenation derivatives (2008), J. Agric. Food Chem., 56, 7808-7814.
    View publication on PubMed
Search for more literature for 1.13.11.34

Activating Compound

Activating Compound Comment Organism Structure
(13S)-hydroperoxy-9,11-octadecadienoic acid
-
 Solanum tuberosum
(13S)-hydroperoxy-9,11-octadecadienoyl lysophosphatidylcholine 50% activation concentration AC50 is 0.0015 mM Solanum tuberosum

Inhibitors

Inhibitors Comment Organism Structure
(15S)-hydroperoxy-5,8,11,13-eicosatetraenoyl lysophosphatidylcholine
-
 Solanum tuberosum
(17S)-hydroperoxy-4,7,10,13,15,19-docosahexaenoyl lysophosphatidylcholine
-
 Solanum tuberosum
arachidonoyl lysophosphatidylcholine
-
 Solanum tuberosum
additional information no inhibition by 1-linoleoyl lysophosphatidylcholine and (13S)-hydroperoxy-9,11-octadecadienoyl lysophosphatidylcholine Solanum tuberosum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate Solanum tuberosum
-
 leukotriene A4 + H2O
-
 ?
arachidonic acid + O2 Solanum tuberosum
-
 (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate
-
 ?

Organism

Organism UniProt Comment Textmining
Solanum tuberosum
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation
-
 Solanum tuberosum
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate
-
 Solanum tuberosum leukotriene A4 + H2O
-
 ?
arachidonic acid + O2
-
 Solanum tuberosum (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxyeicosa-6,8,11,14-tetraenoate
-
 ?

Synonyms

Synonyms Comment Organism
5-lipoxygenase
-
 Solanum tuberosum

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
 assay at Solanum tuberosum

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.3
-
 assay at Solanum tuberosum

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
additional information
-
 additional information inhibition kinetics, overview Solanum tuberosum
0.00038
-
 arachidonoyl lysophosphatidylcholine pH 6.3, 25°C Solanum tuberosum
0.0019
-
 (17S)-hydroperoxy-4,7,10,13,15,19-docosahexaenoyl lysophosphatidylcholine pH 6.3, 25°C Solanum tuberosum

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0166
-
 pH 6.3, 25°C Solanum tuberosum arachidonoyl lysophosphatidylcholine
0.0241
-
 pH 6.3, 25°C Solanum tuberosum (17S)-hydroperoxy-4,7,10,13,15,19-docosahexaenoyl lysophosphatidylcholine