Reference on EC 1.1.1.62 - 17beta-estradiol 17-dehydrogenase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
LaRhee, L.H.; Warren, J.C.
Purification and characterization of epimeric estradiol dehydrogenases (17alpha and 17beta) from equine placenta
Biochemistry
23
486-491
1984
Equus caballus
Manually annotated by BRENDA team
Strickler, R.C.; Tobias, B.; Covey, D.F.
Human placental 17beta-estradiol dehydrogenase and 20alpha-hydroxysteroid dehydrogenase. Two activities at a single enzyme active site
J. Biol. Chem.
256
316-321
1981
Homo sapiens
Manually annotated by BRENDA team
Blomquist, C.H.; Lindemann, N.J.; Hakanson, E.Y.
17beta-Hydroxysteroid and 20alpha-hydroxysteroid dehydrogenase activities of human placental microsomes: kinetic evidence for two enzymes differing in substrate specificity
Arch. Biochem. Biophys.
239
206-215
1985
Homo sapiens
Manually annotated by BRENDA team
Murdock, G.L.; Warren, J.C.; Sweet, F.
Human placental estradiol 17beta-dehydrogenase: evidence for inverted substrate orientation (wrong-way binding) at the active site
Biochemistry
27
4452-4458
1988
Homo sapiens
Manually annotated by BRENDA team
Mendoza-Hernandez, G.; Lopez-Solache, I.; Diaz-Zagoya, J.C.
Periodate-oxidized NADP+ is a powerful inhibitor of human placental estradiol-17beta dehydrogenase
Biochem. Biophys. Res. Commun.
146
645-651
1987
Homo sapiens
Manually annotated by BRENDA team
Mendoza-Hernandez, G.; Rendon, J.L.; Diaz-Zagoya, J.C.
A single step procedure for purification of estradiol 17beta-dehydrogenase from human placenta
Biochem. Biophys. Res. Commun.
126
477-481
1985
Homo sapiens
Manually annotated by BRENDA team
Mendoza-Hernandez, G.; Calcagno, M.; Sanchez-Nuncio, H.R.; Diaz-Zagoya, J.C.
Dehydroepiandrosterone is a substrate for estradiol 17beta-dehydrogenase from human placenta
Biochem. Biophys. Res. Commun.
119
83-87
1984
Homo sapiens
Manually annotated by BRENDA team
Renwick, A.G.C.; Soon, C.Y.; Chambers, S.M.; Brown, C.R.
Estradiol-17beta dehydrogenase from chicken liver
J. Biol. Chem.
256
1881-1887
1981
Gallus gallus
Manually annotated by BRENDA team
Pollow, K.; Luebbert, H.; Pollow, B.
On the mitochondrial 17beta-hydroxysteroid dehydrogenase from human endometrium and endometrial carcinoma: characterization and intramitochondrial distribution
J. Steroid Biochem.
7
45-50
1976
Homo sapiens
Manually annotated by BRENDA team
Nicolas, J.C.
Purification of an enzyme containing a NADP-protected cysteine on organomercuri-agarose 17beta-estradiol dehydrogenase
Methods Enzymol.
34
552-554
1974
Homo sapiens
Manually annotated by BRENDA team
Nicolas, J.C.
The soluble 17beta-estradiol dehydrogenase of human placenta
Methods Enzymol.
34
555-557
1974
Homo sapiens
Manually annotated by BRENDA team
Nicolas, J.C.; Harris, J.I.
Human placental 17-oestradiol dehydrogenase. Sequence of a tryptic peptide containing an essential cysteine
FEBS Lett.
29
173-176
1973
Homo sapiens
Manually annotated by BRENDA team
Nicolas, J.C.; Pons, M.; Descomps, B.; de Paulet, A.C
Affinity chromatography: large-scale purification of the soluble oestradiol-17-dehydrogenase of human placenta
FEBS Lett.
23
175-179
1972
Homo sapiens
Manually annotated by BRENDA team
Burns, D.J.W.; Engel, L.L.; Bethune, J.L.
Amino acid composition and subunit structure. Human placental 17-estradiol dehydrogenase
Biochemistry
11
2699-2703
1972
Homo sapiens
Manually annotated by BRENDA team
Kautsky, M.P.; Hagerman, D.D.
17beta-Estradiol dehydrogenase of ovine ovaries
J. Biol. Chem.
245
1978-1984
1970
Ovis aries
Manually annotated by BRENDA team
Langer, L.J.; Alexander, J.A.; Engel, L.L.
Human placental estradiol-17beta dehydrogenase
J. Biol. Chem.
234
2609-2614
1959
Homo sapiens
Manually annotated by BRENDA team
Luebbert, H.
Effects of ethanol and other organic solvents on the kinetic behaviour of purified human placental oestradiol-17beta-dehydrogenase
Acta Endocrinol.
99
448-453
1982
Homo sapiens
Manually annotated by BRENDA team
Engel, L.L.; Inano, H.
Some kinetic properties of human placental 17beta-estradiol dehydrogenase: patterns of inhibition by adenine nucleotides
Adv. Enzyme Regul.
17
363-371
1979
Homo sapiens
Manually annotated by BRENDA team
Pollow, K.; Luebbert, H.; Jeske, R.; Pollow, B.
Studies on 17beta-hydroxysteroid dehydrogenase in human endometrium and endometrial carcinoma
Acta Endocrinol.
79
146-156
1975
Homo sapiens
Manually annotated by BRENDA team
Murdock, G.L.; Chin, C.C.; Warren, J.C.
Human placental estradiol 17beta-dehydrogenase: sequence of a histidine-bearing peptide in the catalytic region
Biochemistry
25
641-646
1986
Homo sapiens
Manually annotated by BRENDA team
Chin, C.C.; Dence, J.B.; Warren, J.C.
Crystallization of human placental estradiol 17beta-dehydrogenase. A new method for crystallizing labile enzymes
J. Biol. Chem.
251
3700-3705
1976
Homo sapiens
Manually annotated by BRENDA team
Hara, A.; Nakayama, T.; Nakagawa, M.; Inoue, Y.; Tanabe, H.; Sawada, H.
Kinetic and stereochemical studies on reaction mechanism of mouse liver 17beta-hydroxysteroid dehydrogenases
J. Biochem.
102
1585-1592
1987
Mus musculus
Manually annotated by BRENDA team
Zhu, D.W.; Campbell, R.; Labrie, F.; Lin, S.X.
Crystallization and preliminary crystal structure of the complex of 17beta-hydroxysteroid dehydrogenase with a dual-site inhibitor
J. Steroid Biochem. Mol. Biol.
70
229-235
1999
Homo sapiens
Manually annotated by BRENDA team
Puranen, T.; Poutanen, M.; Ghosh, D.; Vihko, P.; Vihko, R.
Characterization of structural and functional properties of human 17beta-hydroxysteroid dehydrogenase type 1 using recombinant enzymes and site-directed mutagenesis
Mol. Endocrinol.
11
77-86
1997
Homo sapiens
Manually annotated by BRENDA team
Blomquist, C.H.; Leung, B.S.; Zhang, R.; Zhu, Y.; Chang, P.M.
Properties and regulation of 17beta-hydroxysteroid oxidoreductase of OVCAR-3, CAOV-3, and A431 cells: effects of epidermal growth factor, estradiol, and progesterone
J. Cell. Biochem.
59
409-417
1995
Homo sapiens
Manually annotated by BRENDA team
Ng, J.H.; Nesaretnam, K.; Reimann, K.; Lai, L.C.
Effect of retinoic acid and palm oil carotenoids on oestrone sulphatase and oestradiol-17beta hydroxysteroid dehydrogenase activities in MCF-7 and MDA-MB-231 breast cancer cell lines
Int. J. Cancer
88
135-138
2000
Homo sapiens
Manually annotated by BRENDA team
Kaufmann, M.; Carstensen, J.; Husen, B.; Adamski, J.
The tissue distribution of porcine 17beta-estradiol dehydrogenase and its induction by progesterone
J. Steroid Biochem. Mol. Biol.
55
535-539
1995
Sus scrofa
Manually annotated by BRENDA team
Malet, C.; Vacca, A.; Kuttenn, F.; Mauvais-Jarvis, P.
17beta-Estradiol dehydrogenase (E2DH) activity in T47D cells
J. Steroid Biochem. Mol. Biol.
39
769-775
1991
Homo sapiens
Manually annotated by BRENDA team
Newton, C.J.; Butta, A.; Nicholls, J.; Dowsett, M.
Oestradiol synthesis from oestrone in malignant breast epithelial cells: studies on a high affinity, 80 kDa form of oestradiol dehydrogenase
J. Steroid Biochem. Mol. Biol.
42
891-900
1992
Homo sapiens
Manually annotated by BRENDA team
Carstensen, J.F.; Tesdorpf, J.G.; Kaufmann, M.; Markus, M.M.; Husen, B.; Leenders, F.; Jakob, F.; de Launoit, Y.; Adamski, J.
Characterization of 17beta-hydroxysteroid dehydrogenase IV
J. Endocrinol.
150
S3-12
1996
Sus scrofa
Manually annotated by BRENDA team
Sawicki, M.W.; Erman, M.; Puranen, T.; Vihko, P.; Ghosh, D.
Structure of the ternary complex of human 17beta-hydroxysteroid dehydrogenase type 1 with 3-hydroxyestra-1,3,5,7-tetraen-17-one (equilin) and NADP+
Proc. Natl. Acad. Sci. USA
96
840-845
1999
Homo sapiens, Homo sapiens (P14061)
Manually annotated by BRENDA team
Ghosh, D.; Pletnev, V.Z.; Zhu, D.W.; Wawrzak, Z.; Duax, W.L.; Pangborn, W.; Labrie, F.; Lin, S.X.
Structure of human estrogenic 17beta-hydroxysteroid dehydrogenase at 2.20 A resolution
Structure
3
503-513
1995
Homo sapiens
Manually annotated by BRENDA team
Reed, M.J.; Rea, D.; Duncan, L.J.; Parker, M.G.
Regulation of estradiol 17beta-hydroxysteroid dehydrogenase expression and activity by retinoic acid in T47D breast cancer cells
Endocrinology
135
4-9
1994
Homo sapiens
Manually annotated by BRENDA team
Pollow, K.; Elger, W.; Hesslinger, H.; Pollow, B.
Purification and properties of the soluble 17beta-hydroxysteroid dehydrogenase of rabbit uterus
Z. Naturforsch. C
34
726-737
1979
Oryctolagus cuniculus
Manually annotated by BRENDA team
Adamski, J.; Husen, B.; Marks, F.; Jungblut, P.W.
Purification and properties of oestradiol 17beta-dehydrogenase extracted from cytoplasmic vesicles of porcine endometrial cells
Biochem. J.
288
375-381
1992
Sus scrofa
Manually annotated by BRENDA team
Puranen, T.J.; Poutanen, M.H.; Peltoketo, H.E.; Vihko, P.T.; Vihko, R.K.
Site-directed mutagenesis of the putative active site of human 17beta-hydroxysteroid dehydrogenase type 1
Biochem. J.
304
289-293
1994
Homo sapiens
Manually annotated by BRENDA team
Deyashiki, Y.; Ohshima, K.; Nakanishi, M.; Sato, K.; Matsuura, K.; Hara, A.
Molecular cloning and characterization of mouse estradiol 17beta-dehydrogenase (A-specific), a member of the aldoketoreductase family
J. Biol. Chem.
270
10461-10467
1995
Mus musculus
Manually annotated by BRENDA team
Husen, B.; Adamski, J.; Bruns, A.; Deluca, D.; Fuhrmann, K.; Moller, G.; Schwabe, I.; Einspanier, A.
Characterization of 17beta-hydroxysteroid dehydrogenase type 7 in reproductive tissues of the marmoset monkey
Biol. Reprod.
68
2092-2099
2003
Callithrix jacchus (Q9GME2), Callithrix jacchus (Q9N0M8)
Manually annotated by BRENDA team
Brown, W.M.; Metzger, L.E.; Barlow, J.P.; Hunsaker, L.A.; Deck, L.M.; Royer, R.E.; Vander Jagt, D.L.
17-beta-Hydroxysteroid dehydrogenase type 1: computational design of active site inhibitors targeted to the Rossmann fold
Chem. Biol. Interact.
143-144
481-491
2003
Homo sapiens
Manually annotated by BRENDA team
Qiu, W.; Campbell, R.L.; Gangloff, A.; Dupuis, P.; Boivin, R.P.; Tremblay, M.R.; Poirier, D.; Lin, S.X.
A concerted, rational design of type 1 17beta-hydroxysteroid dehydrogenase inhibitors: estradiol-adenosine hybrids with high affinity
FASEB J.
16
1829-1831
2002
Homo sapiens, Homo sapiens (P14061)
Manually annotated by BRENDA team
Zhu, S.J.; Li, Y.; Li, H.; Wang, Y.L.; Xiao, Z.J.; Vihko, P.; Piao, Y.S.
Retinoic acids promote the action of aromatase and 17beta-hydroxysteroid dehydrogenase type 1 on the biosynthesis of 17beta-estradiol in placental cells
J. Endocrinol.
172
31-43
2002
Homo sapiens
Manually annotated by BRENDA team
Pelletier, G.; Luu-The, V.; Li, S.; Ren, L.; Labrie, F.
Localization of 17beta-hydroxysteroid dehydrogenase type 1 mRNA in mouse tissues
J. Mol. Endocrinol.
33
459-465
2004
Mus musculus
Manually annotated by BRENDA team
Takano, H.; Niimura, S.
Changes in the activities of hydroxysteroid dehydrogenases in porcine oocytes during meiotic maturation in vitro
J. Reprod. Dev.
48
303-308
2002
Sus scrofa
-
Manually annotated by BRENDA team
Fiorelli, G.; Picariello, L.; Martineti, V.; Tognarini, I.; Tonelli, F.; Brandi, M.L.
Estrogen metabolism in human colorectal cancer cells
J. Steroid Biochem. Mol. Biol.
81
281-289
2002
Homo sapiens
Manually annotated by BRENDA team
Blomquist, C.H.; Bonenfant, M.; McGinley, D.M.; Posalaky, Z.; Lakatua, D.J.; Tuli-Puri, S.; Bealka, D.G.; Tremblay, Y.
Androgenic and estrogenic 17beta-hydroxysteroid dehydrogenase/17-ketosteroid reductase in human ovarian epithelial tumors: evidence for the type 1, 2 and 5 isoforms
J. Steroid Biochem. Mol. Biol.
81
343-351
2002
Homo sapiens
Manually annotated by BRENDA team
Steckelbroeck, S.; Watzka, M.; Reissinger, A.; Wegener-Toper, P.; Bidlingmaier, F.; Bliesener, N.; Hans, V.H.; Clusmann, H.; Ludwig, M.; Siekmann, L.; Klingmuller, D.
Characterisation of estrogenic 17beta-hydroxysteroid dehydrogenase (17beta-HSD) activity in the human brain
J. Steroid Biochem. Mol. Biol.
86
79-92
2003
Homo sapiens
Manually annotated by BRENDA team
Sahmi, M.; Nicola, E.S.; Silva, J.M.; Price, C.A.
Expression of 17beta- and 3beta-hydroxysteroid dehydrogenases and steroidogenic acute regulatory protein in non-luteinizing bovine granulosa cells in vitro
Mol. Cell. Endocrinol.
223
43-54
2004
Bos taurus
Manually annotated by BRENDA team
Khan, N.; Sharma, K.K.; Andersson, S.; Auchus, R.J.
Human 17beta-hydroxysteroid dehydrogenases types 1, 2, and 3 catalyze bi-directional equilibrium reactions, rather than unidirectional metabolism, in HEK-293 cells
Arch. Biochem. Biophys.
429
50-59
2004
Homo sapiens
Manually annotated by BRENDA team
Poirier, D.
Inhibitors of 17beta-hydroxysteroid dehydrogenases
Curr. Med. Chem.
10
453-477
2003
Homo sapiens
Manually annotated by BRENDA team
Li, Y.; Qin, L.; Xiao, Z.J.; Wang, Y.L.; Herva, R.; Leng, J.H.; Lang, J.H.; Isomaa, V.; Piao, Y.S.
Expression of P450 aromatase and 17beta-hydroxysteroid dehydrogenase type 1 at fetal-maternal interface during tubal pregnancy
J. Steroid Biochem. Mol. Biol.
87
241-246
2003
Homo sapiens
Manually annotated by BRENDA team
Cassetta, A.; Buedefeld, T.; Rizner, T.L.; Kristan, K.; Stojan, J.; Lamba, D.
Crystallization, X-ray diffraction analysis and phasing of 17beta-hydroxysteroid dehydrogenase from the fungus Cochliobolus lunatus
Acta Crystallogr. Sect. F
61
1032-1034
2005
Curvularia lunata
Manually annotated by BRENDA team
Nakanishi, T.; Hiromori, Y.; Yokoyama, H.; Koyanagi, M.; Itoh, N.; Nishikawa, J.; Tanaka, K.
Organotin compounds enhance 17beta-hydroxysteroid dehydrogenase type I activity in human choriocarcinoma JAr cells: potential promotion of 17beta-estradiol biosynthesis in human placenta
Biochem. Pharmacol.
71
1349-1357
2006
Homo sapiens
Manually annotated by BRENDA team
Vicker, N.; Lawrence, H.R.; Allan, G.M.; Bubert, C.; Smith, A.; Tutill, H.J.; Purohit, A.; Day, J.M.; Mahon, M.F.; Reed, M.J.; Potter, B.V.
Focused libraries of 16-substituted estrone derivatives and modified e-ring steroids: inhibitors of 17beta-hydroxysteroid dehydrogenase type 1
ChemMedChem
1
464-481
2006
Homo sapiens
Manually annotated by BRENDA team
Blomquist, C.H.; Lima, P.H.; Tarrant, A.M.; Atkinson, M.J.; Atkinson, S.
17beta-Hydroxysteroid dehydrogenase (17beta-HSD) in scleractinian corals and zooxanthellae
Comp. Biochem. Physiol. B Biochem. Mol. Biol.
143
397-403
2006
Montipora capitata, Tubastraea coccinea
Manually annotated by BRENDA team
Husen, B.; Huhtinen, K.; Saloniemi, T.; Messinger, J.; Thole, H.H.; Poutanen, M.
Human hydroxysteroid (17-beta) dehydrogenase 1 expression enhances estrogen sensitivity of MCF-7 breast cancer cell xenografts
Endocrinology
147
5333-5339
2006
Homo sapiens
Manually annotated by BRENDA team
Tremblay, M.R.; Boivin, R.P.; Luu-The, V.; Poirier, D.
Inhibitors of type 1 17beta-hydroxysteroid dehydrogenase with reduced estrogenic activity: modifications of the positions 3 and 6 of estradiol
J. Enzyme Inhib. Med. Chem.
20
153-163
2005
Homo sapiens
Manually annotated by BRENDA team
Fischer, D.S.; Allan, G.M.; Bubert, C.; Vicker, N.; Smith, A.; Tutill, H.J.; Purohit, A.; Wood, L.; Packham, G.; Mahon, M.F.; Reed, M.J.; Potter, B.V.
E-ring modified steroids as novel potent inhibitors of 17beta-hydroxysteroid dehydrogenase type 1
J. Med. Chem.
48
5749-5770
2005
Homo sapiens
Manually annotated by BRENDA team
Poirier, D.; Boivin, R.P.; Tremblay, M.R.; Berube, M.; Qiu, W.; Lin, S.X.
Estradiol-adenosine hybrid compounds designed to inhibit type 1 17beta-hydroxysteroid dehydrogenase
J. Med. Chem.
48
8134-8147
2005
Homo sapiens
Manually annotated by BRENDA team
Song, D.; Liu, G.; Luu-The, V.; Zhao, D.; Wang, L.; Zhang, H.; Xueling, G.; Li, S.; Desy, L.; Labrie, F.; Pelletier, G.
Expression of aromatase and 17beta-hydroxysteroid dehydrogenase types 1, 7 and 12 in breast cancer. An immunocytochemical study
J. Steroid Biochem. Mol. Biol.
101
136-144
2006
Homo sapiens
Manually annotated by BRENDA team
Pelletier, G.; Luu-The, V.; Li, S.; Labrie, F.
Localization of type 7 17beta-hydroxysteroid dehydrogenase in mouse tissues. In situ hybridization studies
J. Steroid Biochem. Mol. Biol.
93
49-57
2005
Mus musculus, Mus musculus (O88736)
Manually annotated by BRENDA team
Liu, H.; Robert, A.; Luu-The, V.
Cloning and characterization of human form 2 type 7 17beta-hydroxysteroid dehydrogenase, a primarily 3beta-keto reductase and estrogen activating and androgen inactivating enzyme
J. Steroid Biochem. Mol. Biol.
94
173-179
2005
Homo sapiens (Q5MGS6)
Manually annotated by BRENDA team
Brooks, J.D.; Thompson, L.U.
Mammalian lignans and genistein decrease the activities of aromatase and 17beta-hydroxysteroid dehydrogenase in MCF-7 cells
J. Steroid Biochem. Mol. Biol.
94
461-467
2005
Homo sapiens
Manually annotated by BRENDA team
Otsuka, M.; Kato, N.; Ichimura, T.; Abe, S.; Tanaka, Y.; Taniguchi, H.; Hoshida, Y.; Moriyama, M.; Wang, Y.; Shao, R.X.; Narayan, D.; Muroyama, R.; Kanai, F.; Kawabe, T.; Isobe, T.; Omata, M.
Vitamin K2 binds 17beta-hydroxysteroid dehydrogenase 4 and modulates estrogen metabolism
Life Sci.
76
2473-2482
2005
Homo sapiens
Manually annotated by BRENDA team
Messinger, J.; Hirvelae, L.; Husen, B.; Kangas, L.; Koskimies, P.; Pentikaeinen, O.; Saarenketo, P.; Thole, H.
New inhibitors of 17beta-hydroxysteroid dehydrogenase type 1
Mol. Cell. Endocrinol.
248
192-198
2006
Homo sapiens, Homo sapiens (P14061)
Manually annotated by BRENDA team
Purohit, A.; Tutill, H.J.; Day, J.M.; Chander, S.K.; Lawrence, H.R.; Allan, G.M.; Fischer, D.S.; Vicker, N.; Newman, S.P.; Potter, B.V.; Reed, M.J.
The regulation and inhibition of 17beta-hydroxysteroid dehydrogenase in breast cancer
Mol. Cell. Endocrinol.
248
199-203
2006
Homo sapiens
Manually annotated by BRENDA team
Allan, G.M.; Bubert, C.; Vicker, N.; Smith, A.; Tutill, H.J.; Purohit, A.; Reed, M.J.; Potter, B.V.
Novel, potent inhibitors of 17beta-hydroxysteroid dehydrogenase type 1
Mol. Cell. Endocrinol.
248
204-207
2006
Homo sapiens, Homo sapiens (P14061)
Manually annotated by BRENDA team
Alho-Richmond, S.; Lilienkampf, A.; Waehaelae, K.
Active site analysis of 17beta-hydroxysteroid dehydrogenase type 1 enzyme complexes with SPROUT
Mol. Cell. Endocrinol.
248
208-213
2006
Homo sapiens (P14061)
Manually annotated by BRENDA team
Poirier, D.; Chang, H.J.; Azzi, A.; Boivin, R.P.; Lin, S.X.
Estrone and estradiol C-16 derivatives as inhibitors of type 1 17beta-hydroxysteroid dehydrogenase
Mol. Cell. Endocrinol.
248
236-238
2006
Homo sapiens (P14061)
Manually annotated by BRENDA team
Day, J.M.; Tutill, H.J.; Newman, S.P.; Purohit, A.; Lawrence, H.R.; Vicker, N.; Potter, B.V.; Reed, M.J.
17beta-Hydroxysteroid dehydrogenase type 1 and type 2: association between mRNA expression and activity in cell lines
Mol. Cell. Endocrinol.
248
246-249
2006
Homo sapiens
Manually annotated by BRENDA team
Lin, S.X.; Shi, R.; Qiu, W.; Azzi, A.; Zhu, D.W.; Dabbagh, H.A.; Zhou, M.
Structural basis of the multispecificity demonstrated by 17beta-hydroxysteroid dehydrogenase types 1 and 5
Mol. Cell. Endocrinol.
248
38-46
2006
Homo sapiens
Manually annotated by BRENDA team
Luu-The, V.; Tremblay, P.; Labrie, F.
Characterization of type 12 17beta-hydroxysteroid dehydrogenase, an isoform of type 3 17beta-hydroxysteroid dehydrogenase responsible for estradiol formation in women
Mol. Endocrinol.
20
437-443
2006
Homo sapiens, Homo sapiens (Q53GQ0)
Manually annotated by BRENDA team
Nagayoshi, Y.; Ohba, T.; Yamamoto, H.; Miyahara, Y.; Tashiro, H.; Katabuchi, H.; Okamura, H.
Characterization of 17beta-hydroxysteroid dehydrogenase type 4 in human ovarian surface epithelial cells
Mol. Hum. Reprod.
11
615-621
2005
Homo sapiens
Manually annotated by BRENDA team
Kristan, K.; Krajnc, K.; Konc, J.; Gobec, S.; Stojan, J.; Lanisnik Rizner, T.
Phytoestrogens as inhibitors of fungal 17beta-hydroxysteroid dehydrogenase
Steroids
70
626-635
2005
Curvularia lunata
Manually annotated by BRENDA team
Kristan, K.; Deluca, D.; Adamski, J.; Stojan, J.; Rizner, T.L.
Dimerization and enzymatic activity of fungal 17beta-hydroxysteroid dehydrogenase from the short-chain dehydrogenase/reductase superfamily
BMC Biochem.
6
28
2005
Curvularia lunata
Manually annotated by BRENDA team
Pelletier, G.; Van, L.; Li, S.; Labrie, F.
Localization of type 8 17beta-hydroxysteroid dehydrogenase mRNA in mouse tissues as studied by in situ hybridization
J. Histochem. Cytochem.
53
1257-1271
2005
Mus musculus
Manually annotated by BRENDA team
Kristan, K.; Stojan, J.; Moeller, G.; Adamski, J.; Rizner, T.L.
Coenzyme specificity in fungal 17beta-hydroxysteroid dehydrogenase
Mol. Cell. Endocrinol.
241
80-87
2005
Curvularia lunata
Manually annotated by BRENDA team
Brozic, P.; Golob, B.; Gomboc, N.; Rizner, T.L.; Gobec, S.
Cinnamic acids as new inhibitors of 17beta-hydroxysteroid dehydrogenase type 5 (AKR1C3)
Mol. Cell. Endocrinol.
248
233-235
2006
Homo sapiens
Manually annotated by BRENDA team
Moeller, G.; Adamski, J.
Multifunctionality of human 17beta-hydroxysteroid dehydrogenases
Mol. Cell. Endocrinol.
248
47-55
2006
Homo sapiens
Manually annotated by BRENDA team
Lukacik, P.; Kavanagh, K.L.; Oppermann, U.
Structure and function of human 17beta-hydroxysteroid dehydrogenases
Mol. Cell. Endocrinol.
248
61-71
2006
Homo sapiens
Manually annotated by BRENDA team
Aizawa, K.; Iemitsu, M.; Maeda, S.; Jesmin, S.; Otsuki, T.; Mowa, C.N.; Miyauchi, T.; Mesaki, N.
Expression of steroidogenic enzymes and synthesis of sex steroid hormones from DHEA in skeletal muscle of rats
Am. J. Physiol.
292
E577-E584
2007
Rattus norvegicus
Manually annotated by BRENDA team
Laplante, Y.; Cadot, C.; Fournier, M.A.; Poirier, D.
Estradiol and estrone C-16 derivatives as inhibitors of type 1 17beta-hydroxysteroid dehydrogenase: blocking of ER+ breast cancer cell proliferation induced by estrone
Bioorg. Med. Chem.
16
1849-1860
2008
Homo sapiens, Homo sapiens (P14061)
Manually annotated by BRENDA team
Allan, G.M.; Vicker, N.; Lawrence, H.R.; Tutill, H.J.; Day, J.M.; Huchet, M.; Ferrandis, E.; Reed, M.J.; Purohit, A.; Potter, B.V.
Novel inhibitors of 17beta-hydroxysteroid dehydrogenase type 1: templates for design
Bioorg. Med. Chem.
16
4438-4456
2008
Homo sapiens, Homo sapiens (P14061)
Manually annotated by BRENDA team
Bey, E.; Marchais-Oberwinkler, S.; Kruchten, P.; Frotscher, M.; Werth, R.; Oster, A.; Alguel, O.; Neugebauer, A.; Hartmann, R.W.
Design, synthesis and biological evaluation of bis(hydroxyphenyl) azoles as potent and selective non-steroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1) for the treatment of estrogen-dependent diseases
Bioorg. Med. Chem.
16
6423-6435
2008
Homo sapiens, Homo sapiens (P14061)
Manually annotated by BRENDA team
Liu, H.; Zheng, S.; Bellemare, V.; Pelletier, G.; Labrie, F.; Luu-The, V.
Expression and localization of estrogenic type 12 17beta-hydroxysteroid dehydrogenase in the cynomolgus monkey
BMC Biochem.
8
2
2007
Macaca fascicularis, Macaca fascicularis (Q4JK77)
Manually annotated by BRENDA team
Brozic, P.; Lanisnik Risner, T.; Gobec, S.
Inhibitors of 17beta-hydroxysteroid dehydrogenase type 1
Curr. Med. Chem.
15
137-150
2008
Homo sapiens (P14061)
Manually annotated by BRENDA team
Bydal, P.; Luu-The, V.; Labrie, F.; Poirier, D.
Steroidal lactones as inhibitors of 17beta-hydroxysteroid dehydrogenase type 5: Chemical synthesis, enzyme inhibitory activity, and assessment of estrogenic and androgenic activities
Eur. J. Med. Chem.
44
632-644
2008
Homo sapiens
Manually annotated by BRENDA team
Day, J.M.; Foster, P.A.; Tutill, H.J.; Parsons, M.F.; Newman, S.P.; Chander, S.K.; Allan, G.M.; Lawrence, H.R.; Vicker, N.; Potter, B.V.; Reed, M.J.; Purohit, A.
17beta-Hydroxysteroid dehydrogenase type 1, and not type 12, is a target for endocrine therapy of hormone-dependent breast cancer
Int. J. Cancer
122
1931-1940
2008
Homo sapiens, Homo sapiens (P14061)
Manually annotated by BRENDA team
Chen, G.; Bourneuf, E.; Marklund, S.; Zamaratskaia, G.; Madej, A.; Lundstroem, K.
Gene expression of 3beta-hydroxysteroid dehydrogenase and 17beta-hydroxysteroid dehydrogenase in relation to androstenone, testosterone, and estrone sulphate in gonadally intact male and castrated pigs
J. Anim. Sci.
85
2457-2463
2007
Sus scrofa
Manually annotated by BRENDA team
Kristan, K.; Stojan, J.; Adamski, J.; Lanisnik Rizner, T.
Rational design of novel mutants of fungal 17beta-hydroxysteroid dehydrogenase
J. Biotechnol.
129
123-130
2007
Curvularia lunata (O93874)
Manually annotated by BRENDA team
Blanchard, P.G.; Luu-The, V.
Differential androgen and estrogen substrates specificity in the mouse and primates type 12 17beta-hydroxysteroid dehydrogenase
J. Endocrinol.
194
449-455
2007
Mus musculus, Mus musculus (Q0VGQ1)
Manually annotated by BRENDA team
Frotscher, M.; Ziegler, E.; Marchais-Oberwinkler, S.; Kruchten, P.; Neugebauer, A.; Fetzer, L.; Scherer, C.; Mueller-Vieira, U.; Messinger, J.; Thole, H.; Hartmann, R.W.
Design, synthesis, and biological evaluation of (hydroxyphenyl)naphthalene and -quinoline derivatives: potent and selective nonsteroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1) for the treatment of estrogen-dependent disease
J. Med. Chem.
51
2158-2169
2008
Homo sapiens, Homo sapiens (P14061)
Manually annotated by BRENDA team
Brown, K.A.; Sayasith, K.; Bouchard, N.; Lussier, J.G.; Sirois, J.
Molecular cloning of equine 17beta-hydroxysteroid dehydrogenase type 1 and its downregulation during follicular luteinization in vivo
J. Mol. Endocrinol.
38
67-78
2007
Equus caballus (A3QRK1), Equus caballus
Manually annotated by BRENDA team
Luu-The, V.; Ferraris, C.; Duche, D.; Belanger, P.; Leclaire, J.; Labrie, F.
Steroid metabolism and profile of steroidogenic gene expression in Episkin: high similarity with human epidermis
J. Steroid Biochem. Mol. Biol.
107
30-36
2007
Homo sapiens
Manually annotated by BRENDA team
Ohno, S.; Nishikawa, K.; Honda, Y.; Nakajin, S.
Expression in E. coli and tissue distribution of the human homologue of the mouse Ke 6 gene, 17beta-hydroxysteroid dehydrogenase type 8
Mol. Cell. Biochem.
309
209-215
2008
Homo sapiens
Manually annotated by BRENDA team
Saloniemi, T.; Lamminen, T.; Huhtinen, K.; Welsh, M.; Saunders, P.; Kujari, H.; Poutanen, M.
Activation of androgens by hydroxysteroid (17beta) dehydrogenase 1 in vivo as a cause of prenatal masculinization and ovarian benign serous cystadenomas
Mol. Endocrinol.
21
2627-2636
2007
Homo sapiens, Homo sapiens (P14016)
Manually annotated by BRENDA team
Parthasarathy, C.; Balasubramanian, K.
Assessment of in vitro effects of metyrapone on Leydig cell steroidogenesis
Steroids
73
328-338
2008
Rattus norvegicus
Manually annotated by BRENDA team
Fournier, D.; Poirier, D.; Mazumdar, M.; Lin, S.X.
Design and synthesis of bisubstrate inhibitors of type 1 17beta-hydroxysteroid dehydrogenase: overview and perspectives
Eur. J. Med. Chem.
43
2298-2306
2008
Homo sapiens (P14061)
Manually annotated by BRENDA team
Bak, B.; Carpio, L.; Kipp, J.L.; Lamba, P.; Wang, Y.; Ge, R.S.; Hardy, M.P.; Mayo, K.E.; Bernard, D.J.
Activins regulate 17beta-hydroxysteroid dehydrogenase type I transcription in murine gonadotrope cells
J. Endocrinol.
201
89-104
2009
Mus musculus
Manually annotated by BRENDA team
Marchais-Oberwinkler, S.; Kruchten, P.; Frotscher, M.; Ziegler, E.; Neugebauer, A.; Bhoga, U.; Bey, E.; Mueller-Vieira, U.; Messinger, J.; Thole, H.; Hartmann, R.W.
Substituted 6-phenyl-2-naphthols. Potent and selective nonsteroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1): design, synthesis, biological evaluation, and pharmacokinetics
J. Med. Chem.
51
4685-4698
2008
Homo sapiens (P14061)
Manually annotated by BRENDA team
El-Kabbani, O.; Scammells, P.J.; Gosling, J.; Dhagat, U.; Endo, S.; Matsunaga, T.; Soda, M.; Hara, A.
Structure-guided design, synthesis, and evaluation of salicylic acid-based inhibitors targeting a selectivity pocket in the active site of human 20alpha-hydroxysteroid dehydrogenase (AKR1C1)
J. Med. Chem.
52
3259-3264
2009
Homo sapiens
Manually annotated by BRENDA team
Lota, R.K.; Olusanjo, M.S.; Dhanani, S.; Owen, C.P.; Ahmed, S.
Synthesis, biochemical evaluation and rationalisation of the inhibitory activity of a range of 4-hydroxyphenyl ketones as potent and specific inhibitors of the type 3 of 17beta-hydroxysteroid dehydrogenase (17beta-HSD3)
J. Steroid Biochem. Mol. Biol.
111
128-137
2008
Rattus norvegicus
Manually annotated by BRENDA team
Bellemare, V.; Laberge, P.; Noel, S.; Tchernof, A.; Luu-The, V.
Differential estrogenic 17beta-hydroxysteroid dehydrogenase activity and type 12 17beta-hydroxysteroid dehydrogenase expression levels in preadipocytes and differentiated adipocytes
J. Steroid Biochem. Mol. Biol.
114
129-134
2009
Homo sapiens
Manually annotated by BRENDA team
Kruchten, P.; Werth, R.; Bey, E.; Oster, A.; Marchais-Oberwinkler, S.; Frotscher, M.; Hartmann, R.W.
Selective inhibition of 17beta-hydroxysteroid dehydrogenase type 1 (17betaHSD1) reduces estrogen responsive cell growth of T47-D breast cancer cells
J. Steroid Biochem. Mol. Biol.
114
200-206
2009
Homo sapiens
Manually annotated by BRENDA team
Al-Soud, Y.A.; Bey, E.; Oster, A.; Marchais-Oberwinkler, S.; Werth, R.; Kruchten, P.; Frotscher, M.; Hartmann, R.W.
The role of the heterocycle in bis(hydroxyphenyl)triazoles for inhibition of 17beta-hydroxysteroid dehydrogenase (17beta-HSD) type 1 and type 2
Mol. Cell. Endocrinol.
301
212-215
2009
Homo sapiens
Manually annotated by BRENDA team
Messinger, J.; Husen, B.; Koskimies, P.; Hirvelae, L.; Kallio, L.; Saarenketo, P.; Thole, H.
Estrone C15 derivatives--a new class of 17beta-hydroxysteroid dehydrogenase type 1 inhibitors
Mol. Cell. Endocrinol.
301
216-224
2009
Homo sapiens, Homo sapiens (P14061)
Manually annotated by BRENDA team
Karkola, S.; Alho-Richmond, S.; Wahala, K.
Pharmacophore modelling of 17beta-HSD1 enzyme based on active inhibitors and enzyme structure
Mol. Cell. Endocrinol.
301
225-228
2009
Homo sapiens (P14061)
Manually annotated by BRENDA team
Brozic, P.; Kocbek, P.; Sova, M.; Kristl, J.; Martens, S.; Adamski, J.; Gobec, S.; Lanisnik Rizner, T.
Flavonoids and cinnamic acid derivatives as inhibitors of 17beta-hydroxysteroid dehydrogenase type 1
Mol. Cell. Endocrinol.
301
229-234
2009
Homo sapiens (P14061)
Manually annotated by BRENDA team
Nashev, L.G.; Schuster, D.; Laggner, C.; Sodha, S.; Langer, T.; Wolber, G.; Odermatt, A.
The UV-filter benzophenone-1 inhibits 17beta-hydroxysteroid dehydrogenase type 3: Virtual screening as a strategy to identify potential endocrine disrupting chemicals
Biochem. Pharmacol.
79
1189-1199
2010
Homo sapiens
Manually annotated by BRENDA team
Oster, A.; Klein, T.; Werth, R.; Kruchten, P.; Bey, E.; Negri, M.; Marchais-Oberwinkler, S.; Frotscher, M.; Hartmann, R.W.
Novel estrone mimetics with high 17beta-HSD1 inhibitory activity
Bioorg. Med. Chem.
18
3494-3505
2010
Homo sapiens, Homo sapiens (P14061)
Manually annotated by BRENDA team
London, S.E.; Itoh, Y.; Lance, V.A.; Wise, P.M.; Ekanayake, P.S.; Oyama, R.K.; Arnold, A.P.; Schlinger, B.A.
Neural expression and post-transcriptional dosage compensation of the steroid metabolic enzyme 17beta-HSD type 4
BMC Neurosci.
11
47
2010
Taeniopygia guttata
Manually annotated by BRENDA team
Chanplakorn, N.; Chanplakorn, P.; Suzuki, T.; Ono, K.; Chan, M.; Miki, Y.; Saji, S.; Ueno, T.; Toi, M.; Sasano, H.
Increased estrogen sulfatase (STS) and 17ßhydroxysteroid dehydrogenase type l(17ß-HSD1) following neoadjuvant aromatase inhibitor therapy in breast cancer patients
Breast Cancer Res. Treat.
120
639-648
2010
Homo sapiens
Manually annotated by BRENDA team
Hong, Y.; Chen, S.
Aromatase, estrone sulfatase, and 17beta-hydroxysteroid dehydrogenase: Structure-function studies and inhibitor development
Mol. Cell. Endocrinol.
340
120-126
2011
Homo sapiens
Manually annotated by BRENDA team
Negri, M.; Recanatini, M.; Hartmann, R.W.
Insights in 17beta-HSD1 enzyme kinetics and ligand binding by dynamic motion investigation
PLoS ONE
5
e12026
2010
Homo sapiens (P14061)
Manually annotated by BRENDA team
Starcevic, S.; Brozic, P.; Turk, S.; Cesar, J.; Lanisnik Rizner, T.; Gobec, S.
Synthesis and biological evaluation of (6- and 7-Phenyl) coumarin derivatives as selective nonsteroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 1
J. Med. Chem.
54
248-261
2011
Homo sapiens (P14061)
Manually annotated by BRENDA team
Beranic, N.; Rizner, T.L.
Effects of progestins on local estradiol biosynthesis and action in the Z-12 endometriotic epithelial cell line
J. Steroid Biochem. Mol. Biol.
132
303-310
2012
Homo sapiens, Homo sapiens (P14061), Homo sapiens (P37059)
Manually annotated by BRENDA team
Lima, D.; MacHado, A.; Reis-Henriques, M.; Rocha, E.; Santos, M.; Castro, L.
Cloning and expression analysis of the 17beta hydroxysteroid dehydrogenase type 12 (HSD17B12) in the neogastropod Nucella lapillus
J. Steroid Biochem. Mol. Biol.
134
8-14
2013
Nucella lapillus (K7S9E9), Nucella lapillus
Manually annotated by BRENDA team
Wang, C.L.; Ying, S.J.; Wang, Z.Y.; Xing, H.J.; Wang, L.Z.; He, D.Y.; Xiao, S.H.; Wang, F.
Molecular cloning and expression of 17beta-hydroxysteroid dehydrogenase type 2 gene in Hu sheep
Mol. Biol. Rep.
40
1073-1080
2013
Ovis aries
Manually annotated by BRENDA team
Spadaro, A.; Negri, M.; Marchais-Oberwinkler, S.; Bey, E.; Frotscher, M.
Hydroxybenzothiazoles as new nonsteroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1)
PLoS ONE
7
e29252
2012
Homo sapiens (P14061)
Manually annotated by BRENDA team
Zhang, C.; Chen, J.; Yin, D.; Lin, S.
The contribution of 17beta-hydroxysteroid dehydrogenase type 1 to the estradiol-estrone ratio in estrogen-sensitive breast cancer cells
PLoS ONE
7
e29835
2012
Homo sapiens (P14061), Homo sapiens (P37059)
Manually annotated by BRENDA team
Sivik, T.; Gunnarsson, C.; Fornander, T.; Nordenskjoeld, B.; Skoog, L.; Stal, O.; Jansson, A.
17beta-Hydroxysteroid dehydrogenase type 14 is a predictive marker for tamoxifen response in oestrogen receptor positive breast cancer
PLoS ONE
7
e40568
2012
Homo sapiens (Q9BPX1)
Manually annotated by BRENDA team
Muthusamy, S.; Andersson, S.; Kim, H.J.; Butler, R.; Waage, L.; Bergerheim, U.; Gustafsson, J.A.
Estrogen receptor beta and 17beta-hydroxysteroid dehydrogenase type 6, a growth regulatory pathway that is lost in prostate cancer
Proc. Natl. Acad. Sci. USA
108
20090-20094
2011
Homo sapiens (O14756)
Manually annotated by BRENDA team