Cloned (Comment) | Organism |
---|---|
gene HSD17B4, located on the Z-chromosome | Taeniopygia guttata |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
17beta-estradiol + NAD(P)+ | Taeniopygia guttata | - |
estrone + NAD(P)H + H+ | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Taeniopygia guttata | H0YSD6 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | HSD17B4 mRNA is expressed more in the song regions of males compared to females throughout development. Females have significantly higher levels of HSD17B4 mRNA in auditory (caudomedial nidopallium) and visual (hyperpalliumapicale)regions than does males at day 25 | Taeniopygia guttata | - |
caudolateral nidopallium | no sex differences in enzyme expression | Taeniopygia guttata | - |
hippocampus | no sex differences in enzyme expression | Taeniopygia guttata | - |
additional information | co-localization of HSD17B4 and androgen receptor mRNA | Taeniopygia guttata | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
17beta-estradiol + NAD(P)+ | - |
Taeniopygia guttata | estrone + NAD(P)H + H+ | - |
r |
Synonyms | Comment | Organism |
---|---|---|
17beta-hydroxysteroid dehydrogenase type IV | - |
Taeniopygia guttata |
HSD17B4 | - |
Taeniopygia guttata |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Taeniopygia guttata | |
NADH | - |
Taeniopygia guttata | |
NADP+ | - |
Taeniopygia guttata | |
NADPH | - |
Taeniopygia guttata |
Organism | Comment | Expression |
---|---|---|
Taeniopygia guttata | 17beta-estradiol treatments increase HSD17B4 mRNA in the auditory region of males, which is contraryto findings in the song system | up |
General Information | Comment | Organism |
---|---|---|
physiological function | 17beta-hydroxysteroiddehydrogenasetype IV (HSD17B4),coding for a steroidogenic enzyme that converts estradiol (E2) into an inactive metabolite. HSD17B4 mRNA is expressed more in the song regions of males compared to females throughout development, suggesting that regulation of E2 is important for male-typical song development. 17beta-Estradiol treatments increase HSD17B4 mRNA in the auditory region of males, which is contraryto findings in the song system. Different behaviors may be guided by the same genes and hormones, but the exact nature of the gene-hormone relationships may differ according to brain region and behavior | Taeniopygia guttata |