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Literature summary for 1.1.1.62 extracted from

  • Tomaszycki, M.L.; Dzubur, E.
    17beta-Hydroxysteroid dehydrogenase type IV, a Z-linked gene, is higher in females than in males in visual and auditory regions of developing zebra finches (2013), Brain Res., 1520, 95-106.
    View publication on PubMed
Search for more literature for 1.1.1.62

Cloned(Commentary)

Cloned (Comment) Organism
gene HSD17B4, located on the Z-chromosome Taeniopygia guttata

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
17beta-estradiol + NAD(P)+ Taeniopygia guttata
-
 estrone + NAD(P)H + H+
-
 r

Organism

Organism UniProt Comment Textmining
Taeniopygia guttata H0YSD6
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain HSD17B4 mRNA is expressed more in the song regions of males compared to females throughout development. Females have significantly higher levels of HSD17B4 mRNA in auditory (caudomedial nidopallium) and visual (hyperpalliumapicale)regions than does males at day 25 Taeniopygia guttata
-
caudolateral nidopallium no sex differences in enzyme expression Taeniopygia guttata
-
hippocampus no sex differences in enzyme expression Taeniopygia guttata
-
additional information co-localization of HSD17B4 and androgen receptor mRNA Taeniopygia guttata
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
17beta-estradiol + NAD(P)+
-
 Taeniopygia guttata estrone + NAD(P)H + H+
-
 r

Synonyms

Synonyms Comment Organism
17beta-hydroxysteroid dehydrogenase type IV
-
 Taeniopygia guttata
HSD17B4
-
 Taeniopygia guttata

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Taeniopygia guttata
NADH
-
 Taeniopygia guttata
NADP+
-
 Taeniopygia guttata
NADPH
-
 Taeniopygia guttata

Expression

Organism Comment Expression
Taeniopygia guttata 17beta-estradiol treatments increase HSD17B4 mRNA in the auditory region of males, which is contraryto findings in the song system up

General Information

General Information Comment Organism
physiological function 17beta-hydroxysteroiddehydrogenasetype IV (HSD17B4),coding for a steroidogenic enzyme that converts estradiol (E2) into an inactive metabolite. HSD17B4 mRNA is expressed more in the song regions of males compared to females throughout development, suggesting that regulation of E2 is important for male-typical song development. 17beta-Estradiol treatments increase HSD17B4 mRNA in the auditory region of males, which is contraryto findings in the song system. Different behaviors may be guided by the same genes and hormones, but the exact nature of the gene-hormone relationships may differ according to brain region and behavior Taeniopygia guttata