Organism | UniProt | Comment | Textmining |
---|---|---|---|
Nucella lapillus | K7S9E9 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
digestive gland | - |
Nucella lapillus | - |
digestive gland | ubiquitously expressed in all tissues analyzed, with higher levels in organs with high metabolic rates, such as kidney and digestive gland | Nucella lapillus | - |
kidney | - |
Nucella lapillus | - |
kidney | ubiquitously expressed in all tissues analyzed, with higher levels in organs with high metabolic rates, such as kidney and digestive gland | Nucella lapillus | - |
additional information | ubiquitously expressed in all tissues analyzed, with higher levels in organs with high metabolic rates, such as kidney and digestive gland | Nucella lapillus | - |
additional information | NlHsd17b12 is ubiquitously expressed in all tissues analyzed, with higher levels in organs with high metabolic rates, such as kidney and digestive gland, a pattern consistent with an involvement in lipid metabolism, detailed tissue distribution through quantitative PCR | Nucella lapillus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
17beta-estradiol + NAD(P)+ | - |
Nucella lapillus | estrone + NAD(P)H + H+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
17-beta-hydroxysteroid dehydrogenase type 12 | - |
Nucella lapillus |
HSD17B12 | - |
Nucella lapillus |
NlHsd17b12 | - |
Nucella lapillus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Nucella lapillus | |
NADH | - |
Nucella lapillus | |
NADP+ | - |
Nucella lapillus | |
NADPH | - |
Nucella lapillus |
Organism | Comment | Expression |
---|---|---|
Nucella lapillus | exposure to tributyltin chloride at 100 ng Sn2+/l causes a decrease in mRNA levels in digestive gland, after one and two months, while no effect is observed in gonads | down |
General Information | Comment | Organism |
---|---|---|
evolution | HSD17B12 is a member of the hydroxysteroid dehydrogenase superfamily, a multifunctional group of enzymes involved in the metabolism of steroids, retinoids, bile and fatty acids | Nucella lapillus |
physiological function | that in mollusks, as in mammals, this enzyme is likely to be involved in lipid metabolism | Nucella lapillus |