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Literature summary for 1.1.1.62 extracted from

  • Fiorelli, G.; Picariello, L.; Martineti, V.; Tognarini, I.; Tonelli, F.; Brandi, M.L.
    Estrogen metabolism in human colorectal cancer cells (2002), J. Steroid Biochem. Mol. Biol., 81, 281-289.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
vitamin D3 activates oxidative activity in HCT8 and LoVo cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
vitamin D3 inhibits reductive activity in HCT8 and LoVo cells Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4-androstene-3,17-dione + NADPH + H+ Homo sapiens 17beta-HSD3 and 5, formation of active androgens in testis and prostate testosterone + NADP+
-
?
estradiol-17beta + NADP+ Homo sapiens 17beta-HSD2, important role in peripheral inactivation of androgens and estrogens, 17beta-HSD4, low substrate affinity estrone + NADPH
-
?
estrone + NADPH + H+ Homo sapiens 17beta-HSD1, final step in the synthesis of active estrogens estradiol-17beta + NADP+
-
?
testosterone + NADP+ Homo sapiens 17beta-HSD2, important role in peripheral inactivation of androgens and estrogens 4-androstene-3,17-dione + NADPH + H+
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
isoforms 1-4, 17beta-HSD 1-4
-

Reaction

Reaction Comment Organism Reaction ID
17beta-estradiol + NAD(P)+ = estrone + NAD(P)H + H+ 5 isoforms with different substrate specificities and tissue distribution, 17beta-HSD1 predominantly catalyzes the reaction of estrone to estradiol-17beta, 17beta-HSD2 catalyzes the reaction of estradiol-17beta to estrone and testosterone to androstenedione, 17beta-HSD3 and 5 catalyzes the reaction of androstenedione to testosterone, 17beta-HSD4 catalyzes the reaction of estradiol-17beta to estrone with low substrate affinty Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
colorectal cancer cell
-
Homo sapiens
-
DLD-1 cell cultured cells, expresses 17beta-HSD isoforms 1-4 Homo sapiens
-
HCT-116 cell cultured cells, expresses 17beta-HSD isoforms 1-4 Homo sapiens
-
HCT-8 cell cultured cells, expresses 17beta-HSD isoforms 1-4 Homo sapiens
-
LoVo cell cultured cells, expresses 17beta-HSD isoforms 1-4 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-androstene-3,17-dione + NADPH + H+ 17beta-HSD3 and 5, formation of active androgens in testis and prostate Homo sapiens testosterone + NADP+
-
?
estradiol-17beta + NADP+ 17beta-HSD2, important role in peripheral inactivation of androgens and estrogens, 17beta-HSD4, low substrate affinity Homo sapiens estrone + NADPH
-
?
estradiol-17beta + NADP+ reverse reaction catalyzed by different isoforms of the enzyme Homo sapiens estrone + NADPH
-
?
estrone + NADPH + H+ 17beta-HSD1, final step in the synthesis of active estrogens Homo sapiens estradiol-17beta + NADP+
-
?
estrone + NADPH + H+ reverse reaction catalyzed by different isoforms of the enzyme Homo sapiens estradiol-17beta + NADP+
-
?
testosterone + NADP+ 17beta-HSD2, important role in peripheral inactivation of androgens and estrogens Homo sapiens 4-androstene-3,17-dione + NADPH + H+
-
?

Cofactor

Cofactor Comment Organism Structure
NADP+
-
Homo sapiens
NADPH
-
Homo sapiens