Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.1.1.62 extracted from

  • Beranic, N.; Rizner, T.L.
    Effects of progestins on local estradiol biosynthesis and action in the Z-12 endometriotic epithelial cell line (2012), J. Steroid Biochem. Mol. Biol., 132, 303-310.
    View publication on PubMed

Application

Application Comment Organism
medicine application of medroxyprogestrone acetate, dydrogesterone and dienogest significantly decreases isoforms HSD17B1 and CYP19A1 expression and significantly increases isoform HSD17B2 expression. Dydrogesterone and dienogest also significantly suppress estrogen receptors ESR1 and ESR2 transcription, whereas medroxyprogestrone acetate and dydrogesterone significantly reduce mRNA levels of G protein-coupled estrogen receptor 1. Results thus suggest that in peritoneal endometriosis the beneficial effects of these progestins can be explained by lower HSD17B1 and higher HSD17B2 mRNA and protein levels, which lead to reduced local estradiol biosynthesis Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P14061 isoform HSD17B1
-
Homo sapiens P37059 isoform HSD17B2
-

Source Tissue

Source Tissue Comment Organism Textmining
Z-12 cell endometriotic epithelial cell line Homo sapiens
-

Synonyms

Synonyms Comment Organism
HSD17B1
-
Homo sapiens
HSD17B2
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens application of medroxyprogestrone acetate, dydrogesterone and dienogest significantly decreases isoforms HSD17B1 and CYP19A1 expression and significantly increases isoform HSD17B2 expression. Dydrogesterone and dienogest also significantly suppress estrogen receptors ESR1 and ESR2 transcription, whereas medroxyprogestrone acetate and dydrogesterone significantly reduce mRNA levels of G protein-coupled estrogen receptor 1. Results thus suggest that in peritoneal endometriosis the beneficial effects of these progestins can be explained by lower HSD17B1 and higher HSD17B2 mRNA and protein levels, which lead to reduced local estradiol biosynthesis down