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Literature summary for 1.1.1.62 extracted from

  • Luu-The, V.; Tremblay, P.; Labrie, F.
    Characterization of type 12 17beta-hydroxysteroid dehydrogenase, an isoform of type 3 17beta-hydroxysteroid dehydrogenase responsible for estradiol formation in women (2006), Mol. Endocrinol., 20, 437-443.
    View publication on PubMed

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0035
-
estrone type 12 17beta-hydroxysteroid dehydrogenase Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
estrone + NAD(P)H + H+ Homo sapiens type 12 17beta-hydroxysteroid dehydrogenase plays a role in estrogen formation. Type 12 17beta-hydroxysteroid dehydrogenase is the major estrogenic 17beta-HSD responsible for the conversion of estrone to estradiol in women, especially in the ovary, the predominant source of estrogens before menopause estradiol + NAD(P)+
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q53GQ0
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293 cell stable expressing 17beta-HSD12 Homo sapiens
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mammary gland
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Homo sapiens
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ovary type 12 17beta-hydroxysteroid dehydrogenase is most highly expressed in ovary and mammary gland Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
estrone + NAD(P)H + H+ type 12 17beta-hydroxysteroid dehydrogenase plays a role in estrogen formation. Type 12 17beta-hydroxysteroid dehydrogenase is the major estrogenic 17beta-HSD responsible for the conversion of estrone to estradiol in women, especially in the ovary, the predominant source of estrogens before menopause Homo sapiens estradiol + NAD(P)+
-
?

Synonyms

Synonyms Comment Organism
17beta-HSD12
-
Homo sapiens
type 12 17beta-hydroxysteroid dehydrogenase
-
Homo sapiens