5.1.1.1: alanine racemase

This is an abbreviated version!
For detailed information about alanine racemase, go to the full flat file.

Word Map on EC 5.1.1.1

5.1.1.1

pyridoxal

5'-phosphate

peptidoglycan

racemization

d-cycloserine

stearothermophilus

plp-dependent

d-amino

aldimine

d-alanyl-d-alanine

exosporium

pyridoxal-5'-phosphate-dependent

drug development

5'-phosphate-dependent

d-alanine:d-alanine

medicine

biotechnology

pharmacology

Reaction

Synonyms

1SFT, AAR, alanine racemase, AlaR, ALR, alr-2, ALR1, ALR2, Alr2 racemase, AlrA, AlrAba, AlrBax, AlrMtb, alrTt, ARL, BA0252, BAS0238, CBL/ALR, CdAlr, cystathionine beta-lyase, D-alanine racemase, DadB, DadX, dadXOF4, dal1, EcAlr, EcCBL, EfAlaR, L-Alanine racemase, L-Alanine:D-alanine racemase, MBalr1, MBAlr2, MetC, More, MurI, OEOE_1641, PDB, Racemase, alanine, tAlaRac, TmCBL, wMelCBL

ECTree

5 Isomerases

5.1 Racemases and epimerases

5.1.1 Acting on amino acids and derivatives

5.1.1.1 alanine racemase

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Results	in table
5	Activating Compound
45340	AA Sequence
21	Application
1	CAS Registry Number
70	Cloned(Commentary)
121	Cofactor
28	Crystallization (Commentary)
122	General Information
11	General Stability
33	IC50 Value
288	Inhibitors
32	kcat/KM [mM/s]
30	Ki Value [mM]
166	KM Value [mM]
6	Localization
10	Metals/Ions
112	Molecular Weight [Da]
129	Natural Substrates/ Products (Substrates)
6	Organic Solvent Stability
481	Organism
8	Pathway
144	PDB ID
47	pH Optimum
10	pH Range
6	pH Stability
3	pI Value
1	Posttranslational Modification
76	Protein Variants
59	Purification (Commentary)
5	Reaction
23	Reaction Type
228	Reference
1	Renatured (Commentary)
13	Source Tissue
30	Specific Activity [micromol/min/mg]
15	Storage Stability
303	Substrates and Products (Substrate)
122	Subunits
225	Synonyms
1	Systematic Name
40	Temperature Optimum [°C]
13	Temperature Range [°C]
34	Temperature Stability [°C]
78	Turnover Number [1/s]

pH Range

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pH Range on EC 5.1.1.1 - alanine racemase

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6.5 - 12.5

Caldanaerobacter subterraneus subsp. tengcongensis

activity range

7 - 11

7 - 9.5

7.0: about 45% of maximal activity, 9.5: about 95% of maximal activity

2034

7.5 - 12.5

Alkalihalophilus pseudofirmus

B3VI72

at pH 7.5 and at pH 12.5 activity is just under 40%, at pH 7 and at pH 13 the enzyme is inactive

7.5 - 9

8.5 - 11

9 - 11

Geobacillus stearothermophilus

pH 9: about 50% of maximal activity, pH 11.0: about 35% of maximal activity, racemization from D-Ala to L-Ala

651747