5.1.1.1: alanine racemase

This is an abbreviated version!
For detailed information about alanine racemase, go to the full flat file.

Reaction

Synonyms

1SFT, AAR, alanine racemase, AlaR, ALR, alr-2, ALR1, ALR2, Alr2 racemase, AlrA, AlrAba, AlrBax, AlrMtb, alrTt, ARL, BA0252, BAS0238, CBL/ALR, CdAlr, cystathionine beta-lyase, D-alanine racemase, DadB, DadX, dadXOF4, dal1, EcAlr, EcCBL, EfAlaR, L-Alanine racemase, L-Alanine:D-alanine racemase, MBalr1, MBAlr2, MetC, More, MurI, OEOE_1641, PDB, Racemase, alanine, tAlaRac, TmCBL, wMelCBL

ECTree

     5 Isomerases

         5.1 Racemases and epimerases

             5.1.1 Acting on amino acids and derivatives

                5.1.1.1 alanine racemase

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Results	in table
5	Activating Compound
45340	AA Sequence
21	Application
1	CAS Registry Number
70	Cloned(Commentary)
121	Cofactor
28	Crystallization (Commentary)
122	General Information
11	General Stability
33	IC50 Value
288	Inhibitors
32	kcat/KM [mM/s]
30	Ki Value [mM]
166	KM Value [mM]
6	Localization
10	Metals/Ions
112	Molecular Weight [Da]
129	Natural Substrates/ Products (Substrates)
6	Organic Solvent Stability
481	Organism
8	Pathway
144	PDB ID
47	pH Optimum
10	pH Range
6	pH Stability
3	pI Value
1	Posttranslational Modification
76	Protein Variants
59	Purification (Commentary)
5	Reaction
23	Reaction Type
228	Reference
1	Renatured (Commentary)
13	Source Tissue
30	Specific Activity [micromol/min/mg]
15	Storage Stability
303	Substrates and Products (Substrate)
122	Subunits
225	Synonyms
1	Systematic Name
40	Temperature Optimum [°C]
13	Temperature Range [°C]
34	Temperature Stability [°C]
78	Turnover Number [1/s]

IC50 Value

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IC50 Value on EC 5.1.1.1 - alanine racemase

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IC50 VALUE [mM]

INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.058

(4R)-4-amino-3-isoxazolidinone

Mycobacterium tuberculosis

-

in 100 mM Tris-Tricine, pH 8.5, temperature not specified in the publication

716705

0.0049

1,1'-(2-oxido-1,2,5-oxadiazole-3,4-diyl)-bis (1-(2-thienyl))-methanone

Mycobacterium tuberculosis

-

in 100 mM Tris-Tricine, pH 8.5, temperature not specified in the publication

716705

0.0057

2-(2-hydroxyphenoxy)-N-methylacetamide

Mycobacterium tuberculosis

-

in 100 mM Tris-Tricine, pH 8.5, temperature not specified in the publication

716705

0.0077

2-(4,6-dimethyl-3-oxo-[1,2]thiazolo[5,4-b]pyridin-2-yl)-N-[2-(4-ethoxyphenyl)ethyl]acetamide

Mycobacterium tuberculosis

-

in 100 mM Tris-Tricine, pH 8.5, temperature not specified in the publication

716705

0.0033

2-(4-methoxyphenyl)-1-morpholin-4-ylethanethione

Mycobacterium tuberculosis

-

in 100 mM Tris-Tricine, pH 8.5, temperature not specified in the publication

716705

0.0065

2-(4-methylphenyl)-1-morpholin-4-ylethanethione

Mycobacterium tuberculosis

-

in 100 mM Tris-Tricine, pH 8.5, temperature not specified in the publication

716705

0.0177

2-(9-acridinylamino)benzenepropanoic acid

Aeromonas hydrophila subsp. hydrophila

A0KL98

pH 11.0, 35°C, recombinant His-tagged enzyme

747417

0.0028

2-(hydoxyimino)-6-methyl-2H-benzopyran-3-carboxamide

Mycobacterium tuberculosis

-

in 100 mM Tris-Tricine, pH 8.5, temperature not specified in the publication

716705

0.0131

2-(pyridin-3-ylcarbamothioyl sulfanyl)acetic acid

Mycobacterium tuberculosis

-

in 100 mM Tris-Tricine, pH 8.5, temperature not specified in the publication

716705

0.0016

2-N',2-N',7-N',7-N'-tetramethyl-9H-fluorene-2,7-disulfonohydrazide

Mycobacterium tuberculosis

-

in 100 mM Tris-Tricine, pH 8.5, temperature not specified in the publication

716705

0.006

2-phenyl-1-piperidin-1-ylethanethione

Mycobacterium tuberculosis

-

in 100 mM Tris-Tricine, pH 8.5, temperature not specified in the publication

716705

0.0052

3,3-dihydroxy-1H-quinoline-2,4-dione

Mycobacterium tuberculosis

-

in 100 mM Tris-Tricine, pH 8.5, temperature not specified in the publication

716705

0.0082

5-chloro-N-(3-chloro-4-methoxyphenyl)-2-(methylsulfonyl)pyrimidine-4-carboxamide

Mycobacterium tuberculosis

-

in 100 mM Tris-Tricine, pH 8.5, temperature not specified in the publication

716705

0.001

6-O-[3-chloro-4-(6-methoxycarbonylpyridine-2-carbonyl)oxyphenyl] 2-O-methyl pyridine-2,6-dicarboxylate

Mycobacterium tuberculosis

-

in 100 mM Tris-Tricine, pH 8.5, temperature not specified in the publication

716705

0.0066

anabellamide

Aeromonas hydrophila subsp. hydrophila

A0KL98

pH 11.0, 35°C, recombinant His-tagged enzyme

747417

0.0054 - 1.328

D-cycloserine

5 entries

0.0026

ethyl 3-(pyridin-2-ylthio)propanoate

Mycobacterium tuberculosis

-

in 100 mM Tris-Tricine, pH 8.5, temperature not specified in the publication

716705

0.0156

hematoxylin

Aeromonas hydrophila subsp. hydrophila

A0KL98

pH 11.0, 35°C, recombinant His-tagged enzyme

747417

0.0143

higenamine

Aeromonas hydrophila subsp. hydrophila

A0KL98

pH 11.0, 35°C, recombinant His-tagged enzyme

747417

0.0125

homogentisic acid

Aeromonas hydrophila subsp. hydrophila

A0KL98

pH 11.0, 35°C, recombinant His-tagged enzyme

747417

0.0185

hydroquinone

Aeromonas hydrophila subsp. hydrophila

A0KL98

pH 11.0, 35°C, recombinant His-tagged enzyme

747417

2.1

L-Cycloserine

Staphylococcus aureus

-

pH and temperature not specified in the publication

748310

0.009

N',N',4-trimethylbenzenesulfonohydrazide

Mycobacterium tuberculosis

-

in 100 mM Tris-Tricine, pH 8.5, temperature not specified in the publication

716705

0.0068

N-benzyl-5-chloro-2-methylsulfonylpyrimidine-4-carboxamide

Mycobacterium tuberculosis

-

in 100 mM Tris-Tricine, pH 8.5, temperature not specified in the publication

716705

0.0082

N-hydroxy-2-(2-hydroxyphenoxy)acetamide

Mycobacterium tuberculosis

-

in 100 mM Tris-Tricine, pH 8.5, temperature not specified in the publication

716705

0.0147

patulin

Aeromonas hydrophila subsp. hydrophila

A0KL98

pH 11.0, 35°C, recombinant His-tagged enzyme

747417

0.0086

propyl gallate

Aeromonas hydrophila subsp. hydrophila

A0KL98

pH 11.0, 35°C, recombinant His-tagged enzyme

747417

0.0155

quercetin

Aeromonas hydrophila subsp. hydrophila

A0KL98

pH 11.0, 35°C, recombinant His-tagged enzyme

747417

0.0089

[4-(5-butyl-5-methyl-2(5H)-furanylidene)dihydro-3,5-dioxo-2(3H)-furanylidene]acetic acid

Aeromonas hydrophila subsp. hydrophila

A0KL98

pH 11.0, 35°C, recombinant His-tagged enzyme

747417

0.0054

D-cycloserine

Aeromonas hydrophila subsp. hydrophila

A0KL98

pH 11.0, 35°C, recombinant His-tagged enzyme

747417

0.0264

D-cycloserine

Mycobacterium tuberculosis

-

wild-type enzyme, pH and temperature not specified in the publication

746767

0.65

D-cycloserine

Staphylococcus aureus

-

pH and temperature not specified in the publication

748310

0.712

D-cycloserine

Mycobacterium tuberculosis

-

enzyme mutant R373L, pH and temperature not specified in the publication

746767

1.328

D-cycloserine

Mycobacterium tuberculosis

-

enzyme mutant Y364D, pH and temperature not specified in the publication

746767