5.1.1.1: alanine racemase

This is an abbreviated version!
For detailed information about alanine racemase, go to the full flat file.

Reaction

Synonyms

1SFT, AAR, alanine racemase, AlaR, ALR, alr-2, ALR1, ALR2, Alr2 racemase, AlrA, AlrAba, AlrBax, AlrMtb, alrTt, ARL, BA0252, BAS0238, CBL/ALR, CdAlr, cystathionine beta-lyase, D-alanine racemase, DadB, DadX, dadXOF4, dal1, EcAlr, EcCBL, EfAlaR, L-Alanine racemase, L-Alanine:D-alanine racemase, MBalr1, MBAlr2, MetC, More, MurI, OEOE_1641, PDB, Racemase, alanine, tAlaRac, TmCBL, wMelCBL

ECTree

     5 Isomerases

         5.1 Racemases and epimerases

             5.1.1 Acting on amino acids and derivatives

                5.1.1.1 alanine racemase

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Results	in table
5	Activating Compound
45340	AA Sequence
21	Application
1	CAS Registry Number
70	Cloned(Commentary)
121	Cofactor
28	Crystallization (Commentary)
122	General Information
11	General Stability
33	IC50 Value
288	Inhibitors
32	kcat/KM [mM/s]
30	Ki Value [mM]
166	KM Value [mM]
6	Localization
10	Metals/Ions
112	Molecular Weight [Da]
129	Natural Substrates/ Products (Substrates)
6	Organic Solvent Stability
481	Organism
8	Pathway
144	PDB ID
47	pH Optimum
10	pH Range
6	pH Stability
3	pI Value
1	Posttranslational Modification
76	Protein Variants
59	Purification (Commentary)
5	Reaction
23	Reaction Type
228	Reference
1	Renatured (Commentary)
13	Source Tissue
30	Specific Activity [micromol/min/mg]
15	Storage Stability
303	Substrates and Products (Substrate)
122	Subunits
225	Synonyms
1	Systematic Name
40	Temperature Optimum [°C]
13	Temperature Range [°C]
34	Temperature Stability [°C]
78	Turnover Number [1/s]

General Stability

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General Stability on EC 5.1.1.1 - alanine racemase

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GENERAL STABILITY

ORGANISM

UNIPROT

LITERATURE

5 min, about 50% loss of activity after incubation with 0.08% SDS, 1 M guanidine hydrochloride, 4 M urea, 45% ethanol or 50% dimethyl sulfoxide

Pseudomonas fluorescens

-

2033

5 min, resistant to incubation with 0.08% SDS, 1 M guanidine hydrochloride, 4 M urea, 45% ethanol or 50% dimethyl sulfoxide

Geobacillus stearothermophilus

-

2033

acetate increases the stability of enzyme ALR, enzyme residue A131 mediates the activation and stabilization of enzyme ALR by short chain carboxylates

Ligilactobacillus salivarius

Q1WV14

749379

denatured by 3.5 M urea in one transition phase

Geobacillus stearothermophilus

-

2033

denatured by urea in two transition phases, dissociation of pyridoxal 5'-phosphate with 4.0 M urea, unfolding with 5.5 M urea

Pseudomonas fluorescens

-

2033

in 0.6 M to 1.5 M guanidine hydrochloride the dimeric enzyme is dissociated into a monomeric form, which is catalytically inactive

Geobacillus stearothermophilus

-

2025, 2029

NaB3H4-reduced DadB holoenzyme is resistant to alpha-chymotrypsin and trypsin and is labile only towards subtilisin

Salmonella enterica subsp. enterica serovar Typhimurium

-

2039

pyridoxal 5'-phosphate present in the solvent suppresses the enzyme's unfolding

Peribacillus psychrosaccharolyticus

-

651357

stabilized in presence of monovalent anions including Cl-

Penaeus monodon

-

652947

stable in 30% ammonium sulfate. Irreversibly diminished activity by exposure to ammonium sulfate concentrations near or above 40%, where precipitation occurs

Salmonella enterica subsp. enterica serovar Typhimurium

-

2013