4.4.1.20: leukotriene-C4 synthase
This is an abbreviated version!
For detailed information about leukotriene-C4 synthase, go to the full flat file.
Word Map on EC 4.4.1.20
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4.4.1.20
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asthma
-
lta4
-
cysteinyl
-
5-lipoxygenase
-
arachidonic
-
eosinophil
-
asthmatic
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flap
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bronchial
-
eicosanoids
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aspirin
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cysteinyl-leukotrienes
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cys-lts
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cysltr1
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aspirin-induced
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bronchoconstriction
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5-lipoxygenase-activating
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aspirin-intolerant
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alox5ap
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montelukast
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1-chloro-2,4-dinitrobenzene
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mapeg
-
aspirin-exacerbated
-
rbl-1
-
medicine
-
bronchoconstrictors
-
a23187-stimulated
-
molecular biology
-
drug development
-
analysis
- 4.4.1.20
- asthma
- lta4
-
cysteinyl
-
5-lipoxygenase
-
arachidonic
-
eosinophil
-
asthmatic
- flap
- bronchial
-
eicosanoids
- aspirin
- cysteinyl-leukotrienes
-
cys-lts
-
cysltr1
-
aspirin-induced
-
bronchoconstriction
-
5-lipoxygenase-activating
-
aspirin-intolerant
-
alox5ap
- montelukast
- 1-chloro-2,4-dinitrobenzene
-
mapeg
-
aspirin-exacerbated
- rbl-1
- medicine
-
bronchoconstrictors
-
a23187-stimulated
- molecular biology
- drug development
- analysis
Reaction
Synonyms
(7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate:glutathione leukotriene-transferase (epoxide-ring-opening), EC 2.5.1.37, leukotriene A4:glutathione S-leukotrienyltransferase, leukotriene C4 synthase, leukotriene C4 synthetase, LT C4 synthase, LTC4 synthase, LTC4 synthetase, LTC4S, LTCS, synthase, leukotriene C4
ECTree
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IC50 Value
IC50 Value on EC 4.4.1.20 - leukotriene-C4 synthase
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0.000135
2-benzoyl-5-(5-[(4-chlorophenyl)(methyl)amino]pyridine-2-carbonyl)benzoic acid
Mus musculus
pH 7.8, temperature not specified in the publication, recombinant enzyme
0.000116
2-benzoyl-5-[5-[(4-chlorophenyl)(methyl)amino]pyridine-2-carbonyl]benzoic acid
Homo sapiens
pH not specified in the publication, temperature not specified in the publication
0.000095
5-[5-[(4-chlorophenyl)(cyclopropylmethyl)amino]pyridine-2-carbonyl]-2-(4-methoxybenzoyl)benzoic acid
Homo sapiens
pH not specified in the publication, temperature not specified in the publication
0.000017 - 0.000124
5-[5-[(4-chlorophenyl)(methyl)amino]pyridine-2-carbonyl]-2-(4-methoxybenzoyl)benzoic acid
0.0021
leukotriene C4
Cavia porcellus
-
IC50: 0.0021 mM, inhibits reaction with leukotriene C4 methyl ester
0.000017
Homo sapiens
cell-free assay, the substrate LTA4 is produced in situ, 37°C, pH not specified in the publication
0.000124
5-[5-[(4-chlorophenyl)(methyl)amino]pyridine-2-carbonyl]-2-(4-methoxybenzoyl)benzoic acid
Homo sapiens
pH not specified in the publication, temperature not specified in the publication